Results 91 to 100 of about 14,994 (217)

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. [PDF]

, 2005
BACKGROUND: Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of resistance, but artemisinins are
Albert Kilian, Sarah G Staedke (18026), Grant Dorsey, Yeka Adoke, Dorsey Grant, Kilian Albert, Kristin Banek (18020), Rosenthal Philip J, Grant Dorsey (18025), Moses R Kamya (18018), Reingold, Arthur, Nathan Bakyaita, Banek, Kristin, Staedke, Sarah G, Rosenthal, Philip J., Arthur Reingold (275222), Philip J Rosenthal (18023), Samuel L Nsobya (275219), Banek Kristin, Fred Wabwire-Mangen (18024), Kamya, Moses.R, Albert Kilian (275220), Madeline Slater (275221), Kamya Moses R, Arthur Reingold, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Staedke Sarah G, Sarah G Staedke, Moses R Kamya, Kristin Banek, Kironde, Fred, Slater, Madeline, Dorsey, Grant, Nsobya, Samuel L., Reingold Arthur, Ambrose Talisuna, Fred Kironde (44975), Kilian, Albert, Talisuna, Ambrose, Bakyaita, Nathan, Fred Kironde, Madeline Slater, Rosenthal, Philip J, Nsobya, Samuel L, Ambrose Talisuna (18019), Slater Madeline, Yeka, Adoke, Nsobya Samuel L, Bakyaita Nathan, Kironde Fred, Philip J Rosenthal, Talisuna Ambrose, Adoke Yeka, Samuel L Nsobya, Kamya, Moses R, Staedke, Sarah G., Nathan Bakyaita (18021), Adoke Yeka (18017)   +59 more
core   +2 more sources

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Clinical and parasitological efficacy of artesunate and sulfadoxine-pyrimethamine (AS+SP) for the treatment of uncomplicated falciparum malaria in different transmission settings in India

Journal of Vector Borne Diseases
Background & objectives: In 2010, artesunate and sulfadoxine-pyrimethamine (AS+SP) were adopted as the first-line artemisinin based combination therapy for treatment of uncomplicated Plasmodium falciparum malaria in India. Continuous therapeutic efficacy
Ritesh Ranjha, Rajendra Baharia, H Chalageri Vani, Bina Srivastava, Naseem Ahmed, Supriya Sharma, Prashant Kumar Mallick, Anupkumar R Anvikar, Praveen Kumar Bharti   +8 more
doaj   +1 more source

Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. [PDF]

, 2010
BACKGROUND: The efficacy of amodiaquine (AQ), sulphadoxine-pyrimethamine (SP) and the combination of SP+AQ in the treatment of Cameroonian children with clinical malaria was investigated.
Isabel A Ateh, Ateh Isabel A, Irenee, Domkam, Wilfred F Mbacham, Ateh, Isabel A, Justin B Echouffo-Tcheugui, Cally Roper, Patrice N Mimche, Bantar Tawe, Tawe Bantar, Palmer M Netongo, Hallett, Rachel, Evehe Marie-Solange B, Rachel Hallett, Nji Akindeh M, Evehe, Marie-Solange B, Mimche, Patrice N, Domkam Irenee, Greenwood, Brian, Anthony Ajua, Geoffrey Targett, Brian Greenwood, Targett, Geoffrey, Echouffo-Tcheugui, Justin B, Tawe, Bantar, Ajua Anthony, Ajua, Anthony, Roper Cally, Roper, Cally, Greenwood Brian, Mimche Patrice N, Netongo Palmer M, Akindeh M Nji, Mbacham, Wilfred F, Netongo, Palmer M, Mbacham Wilfred F, Targett Geoffrey, Nji, Akindeh M, Irenee Domkam, Echouffo-Tcheugui Justin B, Marie-Solange B Evehe, Hallett Rachel   +41 more
core   +3 more sources

Therapeutic efficacy of chloroquine and sulfadoxine/pyrimethamine against Plasmodium falciparum infection in Somalia

Bulletin of the World Health Organization, 2002
OBJECTIVE: To assess the efficacy of chloroquine and sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum infections in Somalia.
Warsame M., Abdillahi A., Duale O. Nur, Ismail A. Nur, Hassan A. M., Mohamed A., Warsame A.   +6 more
doaj  

How Sulfadoxine-Pyrimethamine (SP) was Perceived in some Rural Communities After Phasing Out Chloroquine (CQ) as a First-Line Drug for Uncomplicated Malaria in Tanzania: Lessons to Learn Towards Moving from Monotherapy to Fixed Combination Therapy. [PDF]

, 2006
Malaria is a leading cause of death in Sub-Saharan Africa. Tanzania changed its malaria treatment policy from chloroquine (CQ) to Sulphadoxine-Pyrimethamine (SP) as first line drug in August 2001. We wanted to assess the perception and behaviour about SP
Nsimba Stephen ED, StephenED Nsimba, Nsimba, Stephen E D   +2 more
core   +1 more source

Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum [PDF]

, 2006
OBJECTIVES: Treatment of Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a sharp rise in the prevalence and density of gametocytes. We did a randomized trial to determine the effect of treatment of asymptomatic infections
Dunyo, SK, Milligan, P, Edwards, T, Milligan, Paul, Edwards, Tansy, Dunyo, Samuel, Pinder, Margaret, Sutherland, Colin, Targett, Geoffrey   +8 more
core   +1 more source

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases, 2001
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
Llanos-Cuentas A., Campos P., Clendenes M., Canfield C. J., Hutchinson D. B. A.   +4 more
doaj  

The remarkable tenacity of sulfadoxine-pyrimethamine [PDF]

The Lancet Infectious Diseases, 2019
Divala, Titus H, Cohee, Lauren M, Laufer, Miriam K   +2 more
openaire   +3 more sources

Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.

, 2009
Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Chandramohan, Daniel, Mosha, Jacklin, Gosling, Roly, Greenwood, Brian, Cairns, Matthew, Gesase, Samwel   +5 more
core   +1 more source