Results 71 to 80 of about 14,994 (217)

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bié provinces, central Angola [PDF]

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2005
We studied three antimalarial treatments in Caala and Kuito, Angola, in 2002 and 2003. We tested chloroquine (CQ), amodiaquine (AQ) and sulfadoxine-pyrimethamine (SP) in Caala, and AQ, SP and the combinations AQ+artesunate (AQ+AS) and SP+artesunate (SP+AS) in Kuito.
Guthmann, J. P., Ampuero, J., Fortes, F., Van Overmeir, C., Gaboulaud, V., Tobback, S., Dunand, J., Nilton, S., Gillet, P., Franco, J., Denoncin, A., Van Herp, M., Balkan, S., Dujardin, J. C., D'Alessandro, U., Legros, D.   +15 more
openaire   +3 more sources

The Epidemiology of Sickle Cell Disease in Sub‐Saharan Africa: Current Knowledge and Gaps to be Filled

American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.
What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque, Leon Tshilolo, Thomas N. Williams   +2 more
wiley   +1 more source

Antimalarial Drug Resistance: A Brief History of Its Spread in Indonesia

Drug Design, Development and Therapy, 2023
Loeki Enggar Fitri,1,2 Aulia Rahmi Pawestri,1,2 Nuning Winaris,1,2 Agustina Tri Endharti,1 Alif Raudhah Husnul Khotimah,3,4 Hafshah Yasmina Abidah,3,4 John Thomas Rayhan Huwae3,5 1Department of Parasitology Faculty of Medicine, Universitas Brawijaya ...
Fitri LE, Pawestri AR, Winaris N, Endharti AT, Khotimah ARH, Abidah HY, Huwae JTR   +6 more
doaj  

A Molecular Surveillance System for Global Patterns of Drug Resistance in Imported Malaria

Emerging Infectious Diseases, 2003
Analysis of imported malaria in travelers may represent a novel surveillance system for drug-resistant malaria. We analyzed consecutive falciparum malaria isolates from Canadian travelers from 1994 to 2000, for polymorphisms in pfcrt, dhfr, and dhps ...
Annie-Claude Labbé, Samir N. Patel, Ian Crandall, Kevin C. Kain   +3 more
doaj   +1 more source

Parasitic Infections and Associated Cognitive Outcome Among School‐Aged Children in Africa: A Systematic Review

Brain and Behavior, Volume 16, Issue 4, April 2026.
Parasitic infections like schistosomiasis, soil‐transmitted helminths, and malaria can impair nutrient absorption, oxygen supply, and brain function, leading to memory deficits, attention deficits, reduced intelligence quotient, weak academic performance, and motor or executive deficits.
Albertha Maku Adu, David Larbi Simpong, David Mawutor Donkor, Kwaku Sarfo Manu, Maxwell Hubert Antwi, Linus Kpelle, George Nkrumah Osei, Ansumana Bockarie   +7 more
wiley   +1 more source

Time to Act; Let Us Unite to Eliminate Malaria Among Pregnant Women in War Zone From Eastern Democratic Republic of the Congo: A Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Malaria remains a major public health challenge in sub‐Saharan Africa, with the Democratic Republic of the Congo (DR Congo) contributing substantially to the global burden. DR Congo accounts for 12% of global malaria cases. This study aims to assess the intersectionality of epidemiological, immunological, and conflict‐related ...
Aymar Akilimali, Laiba Mehmood, Paradzai Innocent Njazi, Babar Ali, Saad Maqbool, Muhammad Younas, Martin Sagide, Syeda Vilay Zehra Rizvi, Rabbia Munsab, Syeda Umme Abiha Rizvi, Sabika Fatima, Amidu Alhassan, Calvin R. Wei, Amos Kipkorir Langat   +13 more
wiley   +1 more source

Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya. [PDF]

, 2009
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the dhfr and dhps genes are associated with sulphadoxine-pyrimethamine (SP) treatment failure and gametocyte carriage.
Sauerwein, Robert W, Alifrangis, M., Bousema, Teun, Sauerwein, R.W., Christina Howitt, Louis C Gouagna, Oesterholt, Mayke J A M, Omar, S.A., Sutherland, Colin J, Sawa, Patrick, Mayke J A M Oesterholt, Teun Bousema, Howitt Christina, Gouagna, L.C., Bousema, T., Oesterholt, Mjam, Gouagna Louis C., Oesterholt, Mayke JAM, Oesterholt Mayke J. A. M., Howitt, Christina, Oesterholt, M.J.A.M., Patrick Sawa, Colin J Sutherland, Alifrangis Michael, Sutherland Colin J., Omar, Sabah A, Howitt, C., Omar, S. A., Bousema Teun, Sawa, P., Sawa Patrick, Sabah A Omar, Sauerwein Robert W., Sutherland, C. J., Gouagna, Louis-Clément, Michael Alifrangis, Sutherland, C.J., Sauerwein, R. W., Robert W Sauerwein, Alifrangis, Michael, Gouagna, Louis C, Omar Sabah A.   +41 more
core   +2 more sources

Emergence of Plasmodium falciparum pfdhps A581G mutation in Southern Senegal under Seasonal Malaria Chemoprevention pressure, 2020-2023

Communications Medicine
Background: Malaria prevention in Senegal includes the use of Seasonal Malaria Chemoprevention with sulfadoxine-pyrimethamine plus amodiaquine. Prolonged use of sulfadoxine-pyrimethamine, however, can select for mutations in the Plasmodium falciparum ...
Mamadou Alpha Diallo, Abdoulaye Tine, Djiby Sow, Aita Sene, Amy Gaye, Yaye D. Ndiaye, Jules Gomis, Baba Dieye, Awa B. Deme, Mamadou S. Yade, Bassirou Ngom, Mamane N. Garba, Ibrahima M. Ndiaye, Khadim Diongue, Aida Sadikh Badiane, Mame Cheikh Seck, Mouhamadou Ndiaye, Daouda Ndiaye   +17 more
doaj   +1 more source

Artesunate-, sulfadoxine-, and pyrimethamine-induced cardiotoxicity

BLDE University Journal of Health Sciences, 2016
Here, we report oral artesunate, sulphadoxine and pyrimethamine (sp) induced cardio toxicity case in a female patient. Artesunate is a highly efficacious and relatively safe antimalarial drug.
Divya Goel, Shafiqa Aslam, Rani Walia, Akshay Sadhotra   +3 more
doaj   +1 more source