Results 81 to 90 of about 20,006 (291)

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended in the ...
R. Grais, I. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, C. Langendorf, A. Amambua-Ngwa, U. d’Alessandro, P. Guérin, T. Fandeur, C. Sibley   +10 more
semanticscholar   +1 more source

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food.
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
wiley   +1 more source

Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children [PDF]

Paediatrica Indonesiana, 2016
Background Large amount of data show that chloroquine andpyrimethamine-sulfadoxine (PS) as standard drugs for falciparummalaria cause resistance; for that reason new drugs or combina-tion drugs are urgently needed. Artemether is one of the newdrugs. It has been studied extensively in China and SoutheastAsia during the past 10 years.
Tonny H Rampengan, Femmy Tambajong
openaire   +3 more sources

The impact of maternal antenatal treatment with two doses of azithromycin and monthly sulphadoxine-pyrimethamine on child weight, mid-upper arm circumference and head circumference: A randomized controlled trial.

PLoS ONE, 2019
AimIntermittent preventive treatment in pregnancy (IPTp) with azithromycin and monthly sulfadoxine-pyrimethamine increased the mean child weight, mid-upper arm and head circumference at four weeks of age in a rural low-income setting.
Lotta Hallamaa, Yin Bun Cheung, Mari Luntamo, Ulla Ashorn, Teija Kulmala, Charles Mangani, Per Ashorn   +6 more
doaj   +1 more source

Impact of antimalarial resistance and COVID-19 pandemic on malaria care among pregnant women in Northern Uganda (ERASE): protocol of a prospective observational study

BMC Infectious Diseases, 2022
Background Uganda accounts for 5% of all malaria cases and deaths reported globally and, in endemic countries, pregnancy is a risk factor for both acquisition of P. falciparum infection and development of severe malaria.
Francesco Vladimiro Segala, Francesco Di Gennaro, Jerry Ictho, Mariangela L’Episcopia, Emmanuel Onapa, Claudia Marotta, Elda De Vita, James Amone, Valentina Iacobelli, Joseph Ogwang, Giovanni Dall’Oglio, Benedict Ngole, Rita Murri, Lameck Olal, Massimo Fantoni, Samuel Okori, Giovanni Putoto, Carlo Severini, Peter Lochoro, Annalisa Saracino   +19 more
doaj   +1 more source

Community-based Malaria Screening and Treatment for Pregnant Women Receiving Standard Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: A Multicenter (The Gambia, Burkina Faso, and Benin) Cluster-randomized Controlled Trial

Clinical Infectious Diseases, 2018
Adding community-based scheduled malaria screening and treatment to existing intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) strategies did not reduce malaria in pregnancy.
Susana Umberto Lindsay John Kalifa Simon Fanta Halidou Ma Scott D’Alessandro Kendall Bradley Bojang Correa N, S. Scott, U. d’Alessandro, L. Kendall, J. Bradley, K. Bojang, Simon Correa, F. Njie, H. Tinto, M. Traoré-Coulibaly, H. M. Natama, O. Traoré, I. Valéa, A. Nahum, Daniel Ahounou, Francis Bohissou, G. Sondjo, Carine Agbowai, P. Mens, E. Ruizendaal, H. Schallig, Susan Dierickx, K. P. Grietens, L. Duval, L. Conteh, M. Drabo, J. Guth, F. Pagnoni   +27 more
semanticscholar   +1 more source

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis [PDF]

, 2017
The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Brothers, Robert C, Dowd, Cynthia S, Edwards, Rachel L, Hruz, Paul W, Kraft, Thomas E, Maron, Maxim I, Odom John, Audrey R, Tsang, Patricia S, Wang, Xu, Williamson, Kim C, Ziniel, Peter D   +10 more
core   +2 more sources

Highly Water‐Stable 2D MOF as Dual Sensor for the Ultra‐Sensitive Aqueous Phase Detection of Nitrofuran Antibiotics and Organochlorine Pesticides

Small, Volume 21, Issue 3, January 22, 2025.
A chemically robust (aqueous pH = 3‐12 for a day and 3 months in water) Cd‐MOF (IITKGP‐71) is strategically developed for ultrasensitive detection of Nitrofuran (NFZ and NFT) antibiotics and DCN pesticide with high selectivity, rapid responsiveness and excellent recyclability in aqueous medium.
Supriya Mondal, Rupam Sahoo, Madhab C. Das   +2 more
wiley   +1 more source

Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in the Democratic Republic of the Congo: emergence of highly resistant pfdhfr/pfdhps alleles

Journal of Antimicrobial Chemotherapy, 2018
Background In 2005, the Democratic Republic of the Congo (DRC) switched to artesunate/amodiaquine as the first-line antimalarial in response to increasing sulfadoxine/pyrimethamine resistance and adopted intermittent preventive treatment using ...
P. Nkoli Mandoko, Florent Rouvier, Lebon Matendo Kakina, D. Moke Mbongi, Christine Latour, J. Losimba Likwela, D. Ngoyi Mumba, S. K. Bi Shamamba, Jean-Jacques Tamfum Muyembe, L. Muepu Tshilolo, D. Parzy, V. Sinou   +11 more
semanticscholar   +1 more source

Saleability of Anti-malarials in Private Drug Shops in Muheza, Tanzania: A Baseline study in an era of assumed Artemisinin Ccombination Therapy (ACT). [PDF]

, 2011
Artemether-lumefantrine (ALu) replaced sulphadoxine-pymimethamine (SP) as the official first-line anti-malarial in Tanzania in November 2006. So far, artemisinin combination therapy (ACT) is contra-indicated during pregnancy by the national malaria ...
AM Rønn, B Wasunna, C Goodman, C Goodman, DS Tarimo, DS Tarimo, FM Ringsted, Frank M Ringsted, Ib C Bygbjerg, Isolide S Massawe, J Eriksen, M Alifrangis, M Alifrangis, Martha M Lemnge, Ministry of Health and Social Welfare URoT, MM Lemnge, MS Alilio, S Alba, S Alba, SE Nsimba, SE Nsimba, SE Nsimba, United Republic of Tanzania, VR Kamat, WE Harrington, World Health Organization, Z Premji   +26 more
core   +4 more sources