Results 61 to 70 of about 11,797 (221)

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. [PDF]

, 2005
BACKGROUND: Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of resistance, but artemisinins are
Albert Kilian, Sarah G Staedke (18026), Grant Dorsey, Yeka Adoke, Dorsey Grant, Kilian Albert, Kristin Banek (18020), Rosenthal Philip J, Grant Dorsey (18025), Moses R Kamya (18018), Reingold, Arthur, Nathan Bakyaita, Banek, Kristin, Staedke, Sarah G, Rosenthal, Philip J., Arthur Reingold (275222), Philip J Rosenthal (18023), Samuel L Nsobya (275219), Banek Kristin, Fred Wabwire-Mangen (18024), Kamya, Moses.R, Albert Kilian (275220), Madeline Slater (275221), Kamya Moses R, Arthur Reingold, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Staedke Sarah G, Sarah G Staedke, Moses R Kamya, Kristin Banek, Kironde, Fred, Slater, Madeline, Dorsey, Grant, Nsobya, Samuel L., Reingold Arthur, Ambrose Talisuna, Fred Kironde (44975), Kilian, Albert, Talisuna, Ambrose, Bakyaita, Nathan, Fred Kironde, Madeline Slater, Rosenthal, Philip J, Nsobya, Samuel L, Ambrose Talisuna (18019), Slater Madeline, Yeka, Adoke, Nsobya Samuel L, Bakyaita Nathan, Kironde Fred, Philip J Rosenthal, Talisuna Ambrose, Adoke Yeka, Samuel L Nsobya, Kamya, Moses R, Staedke, Sarah G., Nathan Bakyaita (18021), Adoke Yeka (18017)   +59 more
core   +1 more source

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysisResearch in context

EClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile   +25 more
doaj   +1 more source

Amitriptyline Induced Life‐Threatening Steven–Johnson Syndrome: Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Stevens–Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine, and carbamazepine are commonly implicated.
Wondwosen Mengist Dereje, Lidya Yalew, Nardos Tafesse, Teklegiorgis Goshime Getachew   +3 more
wiley   +1 more source

Review of pharmacokinetic studies of sulfadoxine.

, 2013
Review of pharmacokinetic studies of sulfadoxine.
Boris Zanolari (368508), Piero Olliaro (35337), Aggrey Malila (368506), Thomas Mercier (368509), Abdunoor Mulokozi Kabanywanyi (368505), Blaise Genton (67109), Hans-Peter Beck (129757), Thierry Buclin (225085), Eva Maria Hodel (368504), Laurent Arthur Decosterd (368510)   +9 more
core   +1 more source

Dairy goat sulfadoxine depletion trial in milk and diagnostic accuracy of the Charm Rapid One Step Assay (ROSA) SULF test

JDS Communications
In Canada, currently no antibiotics are approved for use in lactating dairy goats. Trimethoprim sulfadoxine is indicated for the treatment of bacterial pneumonia, enteric and septicemic colibacillosis and salmonellosis, infectious pododermatitis, and ...
Miranda Hawley, Joe Smith, Kaitlyn Lawson, Jocelyn Jansen, Rex Crawford, Afolakemi Adeniji, Cathy Bauman   +6 more
doaj   +1 more source

Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy

Emerging Infectious Diseases, 2010
For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase
Philippe Deloron, Gwladys Bertin, Valérie Briand, Achille Massougbodji, Michel Cot   +4 more
doaj   +1 more source

Trends and Patterns of Adverse Drug Reaction Reporting in Sierra Leone: A Retrospective Analysis of VigiFlow Data (2008–2022)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.
ABSTRACT Purpose Adverse drug reactions (ADRs) present significant obstacles for healthcare systems, impacting both patient safety and the effectiveness of treatments. Despite this, there is a scarcity of research on ADR reports in Sierra Leone, especially over long periods.
Isatu Jalloh, Onome Thomas Abiri, Peter Bai James, Rajesh Vagiri, Neelaveni Padayachee   +4 more
wiley   +1 more source

Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications.

, 2006
OBJECTIVE: Our objective was to characterize the pharmacokinetic properties of sulfadoxine-pyrimethamine in African adults and children with acute falciparum malaria.
Evans, A, Barnes, KI, White, NJ, White, Nicholas, Little, F, Watkins, WM, Smith, PJ   +6 more
core   +1 more source

Childhood Linear Growth and Early Morbidity as Predictors of Adolescent Cognitive Ability in Malawi: A Prospective Observational Study

Acta Paediatrica, Volume 115, Issue 3, Page 634-642, March 2026.
ABSTRACT Aim Growth faltering and loss of development potential are common in low‐ and middle‐income countries. We aimed to study whether linear growth before and after 2 years, height‐for‐age Z‐score (HAZ) from 1 month until 13 years and morbidity during the first 3 years predict adolescent cognitive ability.
Karoliina Videman, Jukka M. Leppänen, Lotta Hallamaa, Kenneth Maleta, Per Ashorn, Charles Mangani, Ulla Ashorn   +6 more
wiley   +1 more source

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source