Results 41 to 50 of about 11,797 (221)

Population-based validation of dihydrofolate reductase gene mutations for the prediction of sulfadoxine-pyrimethamine resistance in Uganda.

, 2003
Mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium falciparum have been proposed as molecular markers for the surveillance of sulfadoxine-pyrimethamine (SP)-resistant malaria, but such proposals have not been validated. At 7 Ugandan sites
Watkins, W, Watkins, W., D'Alessandro, U., Langi, P., Egwang, T.G., Mutabingwa, T. K., Egwang, T. G., Mutabingwa, TK, Langi, P, Mutabingwa, T.K., Talisuna, A. O., D'Alessandro, U, Van Marck, E., Van Marck, Eric, d' Alessandro, U., Talisuna, A.O., Van Marck, E, Egwang, TG, Talisuna, AO   +18 more
core   +1 more source

Determinants of Low Birth Weight in Ghana: Analysis of the 2022 Demographic and Health Survey

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Low birth weight (LBW) remains a significant public health challenge in developing countries, contributing substantially to infant mortality and morbidity. Objective To examine sociodemographic, maternal health, and healthcare utilization factors associated with low birth weight in Ghana.
Michael Arthur Ofori, David Kwamena Mensah, Theophilus Asamoah, Michael Fosu Ofori   +3 more
wiley   +1 more source

The impact of maternal antenatal treatment with two doses of azithromycin and monthly sulphadoxine-pyrimethamine on child weight, mid-upper arm circumference and head circumference: A randomized controlled trial.

PLoS ONE, 2019
AimIntermittent preventive treatment in pregnancy (IPTp) with azithromycin and monthly sulfadoxine-pyrimethamine increased the mean child weight, mid-upper arm and head circumference at four weeks of age in a rural low-income setting.
Lotta Hallamaa, Yin Bun Cheung, Mari Luntamo, Ulla Ashorn, Teija Kulmala, Charles Mangani, Per Ashorn   +6 more
doaj   +1 more source

Repositioning 2‐Mercaptobenzothiazole and Sulfonamides as Antifungals Against Multidrug‐Resistant Candida albicans: In Vitro and In Silico Insights

ChemistrySelect, Volume 11, Issue 19, 20 May 2026.
This study highlights the antifungal potential of 2‐mercaptobenzothiazole (MBT) and sulfonamides against multidrug‐resistant Candida albicans. In vitro assays and molecular docking with lanosterol 14α‐demethylase (L14αDM) reveal favorable activity and binding, supporting their repositioning as promising antifungal candidates. ABSTRACT Fungal infections
Bruno A. de Oliveira, Ari Sérgio de Oliveira Lemos, Gabrielle Silva de Campos Lazzarini, Natasha Silva Mayrink, Elaine Soares Coimbra, Adilson D. da Silva, Rodrigo Luiz Fabri   +6 more
wiley   +1 more source

Trends in Veterinary Drug Residues in US Cattle: Analysing USDA Sampling Data

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
National US residue monitoring data (2021–2023) were analysed to characterise veterinary drug residue detections in cattle. Detection patterns varied by cattle type, with dairy cows accounting for the highest number of detections and a consistent group of commonly used drugs responsible for most violative and non‐violative findings.
Abdullah S. Alwahaimed, Joseph Eifert
wiley   +1 more source

Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]

Iranian Journal of Public Health, 2008
Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with re­sistance to chloroquine (CQ) and pyrimethamine, respectively.
MR Razavi, SR Naddaf, JLe Bras, A Raesi, AR Esmaeili, M Assmar   +5 more
doaj   +1 more source

Artesunate-, sulfadoxine-, and pyrimethamine-induced cardiotoxicity

BLDE University Journal of Health Sciences, 2016
Here, we report oral artesunate, sulphadoxine and pyrimethamine (sp) induced cardio toxicity case in a female patient. Artesunate is a highly efficacious and relatively safe antimalarial drug.
Divya Goel, Shafiqa Aslam, Rani Walia, Akshay Sadhotra   +3 more
doaj   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda.

, 2004
We report below an in vivo antimalarial efficacy study conducted in 2002 in Bundi Bugyo, a district of western Uganda housing a large displaced population. We tested sulfadoxine-pyrimethamine (SP), amodiaquine (AQ) and the combination chloroquine plus SP
Francesco Checchi, Balkan, S, Cara Kosack, Klarkowski, D, Ardizzoni, Elisa, Piola, P, Piola, Patrice, Elisa Ardizzoni, Checchi, Francesco, Kosack, C, Eric Kwezi, Ardizzoni, E, Bakyaita, Nathan, Jean-paul Guthmann, Guthmann, J P, Patrice Piola, Gerardo Priotto, Klarkowski, Derryck, Alan Brockman, Nathan Bakyaita, Checchi, F, Priotto, Gerardo, Priotto, G, Guthmann, Jean-Paul, Bakyaita, N, Kosack, Cara, Brockman, Alan, Brockman, A, Kwezi, E, Suna Balkan, Kwezi, Eric, Derryck Klarkowski, Balkan, Suna   +32 more
core   +1 more source

Detection of Falsified Antimalarial Sulfadoxine-Pyrimethamine and Dihydroartemisinin-Piperaquine Drugs Using a Low-Cost Handheld Near-Infrared Spectrometer

Journal of Analytical Methods in Chemistry, 2022
Falsified drugs are of serious concern to public health worldwide, particularly for developing countries where quality control of drugs is inefficient.
Moussa Yabré, Abdoul Karim Sakira, Moumouni Bandé, Bertrand W. F. Goumbri, Sandrine M. Ouattara, Souleymane Fofana, Touridomon Issa Somé   +6 more
doaj   +1 more source