Results 21 to 30 of about 21,848 (263)

Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention [PDF]

Nature Communications
Sulfadoxine-pyrimethamine (SP) is recommended for perennial malaria chemoprevention in young children in high burden areas across Africa. Mutations in the dihydropteroate synthase (dhps) gene (437 G/540E/581 G) associated with sulfadoxine resistance vary
Andria Mousa, Gina Cuomo-Dannenburg, Hayley A. Thompson, David J. Bell, Umberto D’Alessandro, Roly Gosling, Alain Nahum, Karen I. Barnes, Jaishree Raman, Lesley Workmann, Yong See Foo, Jennifer A. Flegg, Emma Filtenborg Hocke, Helle Hansson, Ana Chopo-Pizarro, Khalid B. Beshir, Michael Alifrangis, R. Matthew Chico, Colin J. Sutherland, Lucy C. Okell, Cally Roper   +20 more
doaj   +2 more sources

Therapeutic efficacy of chloroquine and sulfadoxine/pyrimethamine against Plasmodium falciparum infection in Somalia [PDF]

Bulletin of the World Health Organization, 2002
OBJECTIVE: To assess the efficacy of chloroquine and sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum infections in Somalia.
Warsame M., Abdillahi A., Duale O. Nur, Ismail A. Nur, Hassan A. M., Mohamed A., Warsame A.   +6 more
doaj   +3 more sources

Efficacy of Corticosteroids and Intravenous Immunoglobulins in a Patient with Toxic Epidermal Necrolysis Secondary to Sulfadoxine: A Case Report and Literature Review

Reports, 2023
Toxic epidermal necrolysis (TEN) is a rare life-threatening mucocutaneous reaction characterized by epidermal detachment. Treatment success relies on early diagnosis, rapid withdrawal of the causative drug and supportive care.
Alba Escolà-Rodríguez, Ángel Marcos-Fendian, Carla Bastida, Javier Gil Lianes, Pedro Castro, José Manuel Mascaró, Dolors Soy Muner   +6 more
doaj   +1 more source

Country wide surveillance reveals prevalent artemisinin partial resistance mutations with evidence for multiple origins and expansion of high level sulfadoxine-pyrimethamine resistance mutations in northwest Tanzania

medRxiv, 2023
Background: Emergence of artemisinin partial resistance (ArtR) in Plasmodium falciparum in East Africa is a growing threat to the efficacy of artemisinin combination therapies (ACT) and the global efforts for malaria elimination.
J. Juliano, D. Giesbrecht, A. Simkin, A. Fola, B. Lyimo, D. Perus, C. Bakari, R. Madebe, M. D. Seth, C. Mandara, Z. R. Popkin-Hall, R. Moshi, R. B. Mbwambo, K. Niaré, B. MacInnis, F. Francis, D. Mbwambo, I. Garimo, Frank Chacky, S. Aaron, A. Lusasi, F. Molteni, R. Njau, S. Lazaro, A. Mohamed, J. Bailey, D. Ishengoma   +26 more
semanticscholar   +1 more source

Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular surveillance study from 2008 to 2017

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionAfter being used vigorously for the previous two decades to treat P. falciparum, chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin-based combination therapy (artesunate-sulfadoxine-pyrimethamine) in an effort
Sabyasachi Das, Sabyasachi Das, Satyajit Tripathy, Ankita Das, Meenakshi Kumari Sharma, Ayan Nag, Amiya Kumar Hati, Somenath Roy   +7 more
doaj   +1 more source

Evolution and spread of Plasmodium falciparum mutations associated with resistance to sulfadoxine-pyrimethamine in central Africa: a cross-sectional study.

The Lancet Microbe, 2023
BACKGROUND Efficacy of sulfadoxine-pyrimethamine, the malaria chemoprophylaxis used in pregnant women, and in children when combined with amodiaquine, is threatened by the accumulation of mutations in the Plasmodium falciparum dihydropteroate synthase ...
Emilie Guémas, Romain Coppée, Sandie Ménard, Milena du Manoir, S. Nsango, Dieudonné Makaba Mvumbi, E. Nakoune, C. E. Eboumbou Moukoko, M. B. Bouyou Akotet, T. Mirabeau, Sylvie Manguin, Doudou Malekita Yobi, Jean Akiana, L. Kouna, D. P. Mawili Mboumba, D. F. Voumbo-Matoumona, Alliance-Laure Otam, P. Rubbo, J. Lombart, Elisabeth Kwanai, Olivia Cohen, Xavier Iriart, L. Ayong, J. Lekana-Douki, F. Ariey, Antoine Berry   +25 more
semanticscholar   +1 more source

Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine-pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study.

Lancet. Infectious Diseases (Print), 2022
BACKGROUND Seasonal malaria chemoprevention is used in 13 countries in the Sahel region of Africa to prevent malaria in children younger than 5 years. Resistance of Plasmodium falciparum to seasonal malaria chemoprevention drugs across the region is a ...
K. Beshir, Julian K Muwanguzi, J. Nader, Raoul Mansukhani, Aliou Traoré, K. Gamougam, S. Ceesay, Thomas Bazié, F. Kolié, M. Lamine, M. Cairns, Paul C Snell, S. Scott, A. Diallo, C. Merle, J. Ndiaye, Lanto Razafindralambo, Diego Moroso, J. Ouédraogo, I. Zongo, H. Kessely, Daugla Doumagoum, K. Bojang, S. Ceesay, K. Loua, Hamma Maiga, A. Dicko, I. Sagara, I. Laminou, S. Ogboi, Tony Eloike, P. Milligan, C. Sutherland   +32 more
semanticscholar   +1 more source

Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990–2020

PLoS Comput. Biol., 2022
Background Sulfadoxine-pyrimethamine (SP) is recommended in Africa in several antimalarial preventive regimens including Intermittent Preventive Treatment in pregnant women (IPTp), Intermittent Preventive Treatment in infants (IPTi) and Seasonal Malaria ...
J. Flegg, Georgina S. Humphreys, Brenda Montanez, Taryn Strickland, Zaira J Jacome-Meza, K. Barnes, J. Raman, P. Guérin, C. Sibley, S. D. Otienoburu   +9 more
semanticscholar   +1 more source

Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review

Frontiers in Genetics, 2021
Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the disease.
A. Roux, Leah Maharaj, Olukunle O. Oyegoke, Oluwasegun P. Akoniyon, M. Adeleke, R. Maharaj, M. Okpeku   +6 more
semanticscholar   +1 more source

Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells

Viruses, 2020
Despite the severe morbidity caused by Zika fever, its specific treatment is still a challenge for public health. Several research groups have investigated the drug repurposing of chloroquine.
Audrien Alves Andrade de Souza, Lauana Ribas Torres, Lyana Rodrigues Pinto Lima Capobianco, Vanessa Salete de Paula, Cynthia Machado Cascabulho, Kelly Salomão, Maria da Gloria Bonecini-Almeida, Maria de Lourdes Garcia Ferreira, Nubia Boechat, Luiz Carlos da Silva Pinheiro, Elen Mello de Souza   +10 more
doaj   +1 more source