Results 11 to 20 of about 4,042 (165)

SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides [PDF]

Organic Letters, 2020
A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described.
S. Mahapatra, Cristian P. Woroch, T. Butler, Sabrina N Carneiro, Sabrina C. Kwan, S. Khasnavis, Junhai Gu, Jason K. Dutra, B. Vetelino, Justin Bellenger, Christopher W. am Ende, Nicholas D. Ball   +11 more
semanticscholar   +3 more sources

Fun With Unusual Functional Groups: Sulfamates, Phosphoramidates, and Di-tert-butyl Silanols. [PDF]

European J Org Chem
Compared to ubiquitous functional groups such as alcohols, carboxylic acids, amines, and amides, which serve as central “actors” in most organic reactions, sulfamates, phosphoramidates, and di-tert-butyl silanols have historically been viewed as “extras”.
Sathyamoorthi S.
europepmc   +2 more sources

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. [PDF]

PLoS Pathogens
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates.
Stanley C Xie, Chia-Wei Tai, Craig J Morton, Liting Ma, Shih-Chung Huang, Sergio Wittlin, Yawei Du, Yongbo Hu, Con Dogovski, Mina Salimimarand, Robert Griffin, Dylan England, Elisa de la Cruz, Ioanna Deni, Tomas Yeo, Anna Y Burkhard, Josefine Striepen, Kyra A Schindler, Benigno Crespo, Francisco J Gamo, Yogesh Khandokar, Craig A Hutton, Tayla Rabie, Lyn-Marié Birkholtz, Mufuliat T Famodimu, Michael J Delves, Judith Bolsher, Karin M J Koolen, Rianne van der Laak, Anna C C Aguiar, Dhelio B Pereira, Rafael V C Guido, Darren J Creek, David A Fidock, Lawrence R Dick, Stephen L Brand, Alexandra E Gould, Steven Langston, Michael D W Griffin, Leann Tilley   +39 more
doaj   +2 more sources

Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors

Bioorganic Chemistry, 2018
Herein we report the synthesis of a new series of aromatic sulfamates investigated for the inhibition of four human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I, II, IV, and IX.
Valentina Onnis, Davide Moi, Alessio Nocentini   +2 more
exaly   +2 more sources

C‑3- and C‑4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors

ACS Omega, 2018
Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in the treatment of postmenopausal hormone-dependent diseases, including breast cancer, are ...
Dharshini Ganeshapillai, L. W. Lawrence Woo, Mark P. Thomas, Atul Purohit, Barry V. L. Potter   +4 more
doaj   +2 more sources

Stereochemistry matters: Inhibition of carbonic anhydrase II by amino acid derived sulfamates depends on their absolute configuration [PDF]

European Journal of Medicinal Chemistry Reports
Aminoalcohols were converted into the corresponding enantiomeric phenylsulfonamide sulfamates. These compounds proved to be inhibitors of carbonic anhydrase II.
Toni C. Denner, Elsa L. Klett, Niels V. Heise, René Csuk   +3 more
doaj   +2 more sources

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target. [PDF]

PLoS Pathogens
Malaria poses an enormous threat to human health. With ever-increasing resistance to currently deployed antimalarials, new targets and starting point compounds with novel mechanisms of action need to be identified.
Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma, Yogavel Manickam, Yogesh Khandokar, Xi Ye, Con Dogovski, David H Hilko, Craig J Morton, Anne-Sophie C Braun, Michael G Leeming, Bagale Siddharam, Gerald J Shami, Pushpangadan Indira Pradeepkumar, Santosh Panjikar, Sally-Ann Poulsen, Michael D W Griffin, Amit Sharma, Leann Tilley, Stanley C Xie   +19 more
doaj   +2 more sources

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure

ACS Omega, 2019
Tetrahydroisoquinoline (THIQ) 6-O-sulfamate-based anticancer agents, inspired by the endogenous steroid 2-methoxyestradiol and its sulfamate derivatives, are further explored for antiproliferative and microtubule disruptor activity.
Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter   +5 more
doaj   +2 more sources

Rearrangement of Arylsulfamates and Sulfates to Para-Sulfonyl Anilines and Phenols [PDF]

Molecules
The C(sp2)-aryl sulfonate functional group is found in bioactive molecules, but their synthesis can involve extreme temperatures (>190 °C or flash vacuum pyrolysis) and strongly acidic reaction conditions.
Yifei Zhou, Alan M. Jones
doaj   +2 more sources

Pd-Catalyzed Suzuki–Miyaura and Hiyama–Denmark Couplings of Aryl Sulfamates

Organic Letters, 2016
Using a recently discovered precatalyst, the first Pd-catalyzed Suzuki–Miyaura reactions using aryl sulfamates that occur at room temperature are reported.
Patrick R. Melvin, N. Hazari, Megan Mohadjer Beromi, Hemali P Shah, M. Williams   +4 more
semanticscholar   +2 more sources