Results 21 to 30 of about 4,042 (165)

From Identification to Enzymatic Activity Profiling: Comprehensive Characterization of BloCAβ, a Probiotic β-Carbonic Anhydrase From Bifidobacterium longum. [PDF]

Arch Pharm (Weinheim)
Production and biochemical characterization of a new β‐carbonic anhydrase from the probiotic Bifidobacterium longum, one of the main players of human gut microbiota. ABSTRACT The microbiota comprises communities of microorganisms that establish complex relationships with the host and play key roles in physiology, metabolism, and immunity.
Giovannuzzi S, Ammara A, Carradori S, Luca V, Gallorini M, Iacovozzi D, Cataldi A, D'Agostino I, Moi D, Onnis V, Supuran CT, Capasso C.   +11 more
europepmc   +2 more sources

Magnetic Nickel-Containing Heterogeneous Catalysts for the Heck Reaction: Catalyst Design, Performance, and Sustainability. [PDF]

ChemistryOpen
This schematic outlines a general Heck coupling using magnetic nickel‐based catalysts. The reactants are mixed and heated to promote carbon–carbon bond formation and produce a substituted alkene product. After completion, an external magnet enables rapid separation of the nickel catalyst from the reaction mixture.
Karimi F, Sarreshtehdar Aslaheh H, Poursattar Marjani A, Rad-Moghadam K.   +3 more
europepmc   +2 more sources

Hydroxyethylamide substituted triterpenoic acids hold good cytotoxicity for human tumor cells

Results in Chemistry, 2022
Pentacyclic triterpenoic acids, betulinic acid, platanic acid, oleanolic acid and ursolic acid, were acetylated and subsequently converted into mono-, bis- and tris(hydroxyl)ethyl amides.
Toni C. Denner, Sophie Hoenke, Oliver Kraft, Hans-Peter Deigner, Ahmed Al-Harrasi, René Csuk   +5 more
doaj   +1 more source

Ring-Opening of Aziridines by Pendant Sulfamates Allows for Regioselective and Stereospecific Preparations of Vicinal Diamines [PDF]

, 2023
The ring-opening of aziridines by pendant sulfamates is a viable strategy for the rapid preparation of vicinal diamines. Our reaction is compatible with both di-substituted cis and trans aziridines; unsubstituted, N-alkyl, and N-aryl sulfamates engage ...
Someshwar, Nagamalla, Appasaheb, Nirpal, Annu Anna, Thomas, Shyam, Sathyamoorthi, Joel, Mague   +4 more
core   +2 more sources

Investigation of Pyrazoline-Based Aromatic Sulfamates as Carbonic Anhydrase Isoforms I, II, IX, and XII Inhibitors

Medical Sciences Forum, 2022
Four new series of aromatic sulfamates were synthesized and investigated for the inhibition of four human (h) isoforms of zinc enzyme carbonic anhydrase, hCA I, II, IX, and XII.
Davide Moi
doaj   +1 more source

Affinity of Sulfamates and Sulfamides to Carbonic Anhydrase II Isoform: Experimental and Molecular Modeling Approaches

, 2016
Sixteen aromatic and aliphatic sulfamides and sulfamates were synthesized and tested in their inhibition to carbonic anhydrase CAII activity. The weaker inhibition pattern shown by sulfamides as compared to sulfamates is interpreted in this research by ...
Alfonso Maresca (2019517), Luciana Gavernet (2289154), Jose L. Gonzalez Funes (2289157), Claudiu T. Supuran (24658), Guillermina Estiu (105847), Luis Bruno Blanch (507909)   +5 more
core   +7 more sources

Design and synthesis of novel anti-urease imidazothiazole derivatives with promising antibacterial activity against Helicobacter pylori.

PLoS ONE, 2023
Urease enzyme is a known therapeutic drug target for treatment of Helicobacter pylori infection due to its role in settlement and growth in gastric mucosa.
Afnan I Shahin, Sumera Zaib, Seyed-Omar Zaraei, Reena A Kedia, Hanan S Anbar, Muhammad Tayyab Younas, Taleb H Al-Tel, Ghalia Khoder, Mohammed I El-Gamal   +8 more
doaj   +2 more sources

Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs – a joint docking/molecular dynamics study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The binding mode of aromatic sulphonamides and clinically licenced drugs to the three carbonic anhydrase (CA, EC 4.2.1.1) isoforms from the human pathogen V.
Alessandro Bonardi, Alessio Nocentini, Sameh Mohamed Osman, Fatmah Ali Alasmary, Tahani Mazyad Almutairi, Dalal Saied Abdullah, Paola Gratteri, Claudiu T. Supuran   +7 more
doaj   +1 more source

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis.
Claudiu T. Supuran
doaj   +1 more source

Synthesis of N‑Acyl Sulfamates from Fluorosulfates and Amides

, 2019
A novel synthetic strategy toward N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core.
Philippe Gilles (4432363), Wim M. De Borggraeve (110635), Sarah Vangrunderbeeck (6179762), Luc Van Meervelt (1501579), Sam Ceusters (6179765), Cedrick Veryser (4432360)   +5 more
core   +3 more sources