Supersaturating drug delivery system of fixed drug combination: sulfamethoxazole and trimethoprim
Background: The drug supersaturation in the intestinal lumen for few hours could result in high bioavailability. The goal of this study was the development of a supersaturating drug delivery system containing sulfamethoxazole and trimethoprim at fixed dose combination (sulfamethoxazole:trimethoprim 5:1 w/w).
Cassiana Mendes +5 more
openaire +2 more sources
Objective: The present study aimed to evaluate the epidemiological and clinical features, causative drugs, and diagnostic challenges of Fixed drug eruption (FDE) in elderly patients.
Goncagül Babuna Kobaner, Esen Özkaya
doaj +1 more source
Limited association between disinfectant use and either antibiotic or disinfectant susceptibility of Escherichia coli in both poultry and pig husbandry [PDF]
Background Farm disinfectants are widely used in primary production, but questions have been raised if their use can select for antimicrobial resistance.
De Reu, Koen +4 more
core +2 more sources
The prevalence and risk factors of fluoroquinolones and co-trimoxazole resistant Escherichia coli in the Northwest Iran: A retrospective cohort [PDF]
Introduction: Fluoroquinolone (FQ) and co-trimoxazole (STX) are the most effective antibiotics for Escherichia coli; however, antibiotic resistance has become an ever-increasing challenge.
Reyhaneh Ravanbakhsh +6 more
doaj +1 more source
In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteria [PDF]
Objectives: The goal of the present study was to obtain a comprehensive overview of the bacteriostatic and bactericidal effects of six commonly used antibiotics on planktonic as well as on sessile Burkholderia cepacia complex cells.
Coenye, Tom, Nelis, Hans, Peeters, Elke
core +1 more source
Antibiotic-resistant Escherichia Coli from Retail Poultry Meat with Different Antibiotic Use Claims [PDF]
Background We sought to determine if the prevalence of antibiotic-resistant Escherichia coli differed across retail poultry products and among major production categories, including organic, “raised without antibiotics”, and conventional.
Davis, Gregg S. +10 more
core +2 more sources
Laboratory-based surveillance of Shigella spp. from human clinical cases in Colombia, 1997-2018
Introduction: Shigellosis is endemic in low-and middle-income countries, causing approximately 125 million episodes of diarrhea and leading to approximately 160 .000 deaths annually one-third of which is associated with children.
Edna Catering Rodríguez +4 more
doaj +1 more source
Severe bloodstream infection due to KPC-producer e coli in a renal transplant recipient treated with the double-carbapenem regimen and analysis of in vitro synergy testing a case report [PDF]
Transplant recipients are at high risk of infections caused by multidrug resistant microorganisms. Due to the limited thera- peutic options, innovative antimicrobial combinations against carbape- nem-resistant Enterobacteriaceae causing severe infections
CIPOLLA, ALESSIA +11 more
core +1 more source
Current standard therapies for toxoplasmic encephalitis often cause severe adverse events. A 57-year-old HIV-positive man in Japan who had toxoplasmic encephalitis but was intolerant to trimethoprim/sulfamethoxazole, pyrimethamine, sulfadiazine, and ...
Daisuke Shiojiri +4 more
doaj +1 more source
Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype [PDF]
Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs).
Bordignon, Valentina +15 more
core +2 more sources

