Results 21 to 30 of about 1,801 (144)

Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur. [PDF]

Sci Rep
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, notoriously refractory to conventional chemotherapy. Historically, sulfane sulfur-based compounds have been explored for the treatment of HCC, but their efficacy has been ...
Zheng X, Luo Y, Huo R, Wang Y, Chen Y, Chen M, Zhao Q, Li K, Zhang H, Li X, Li X, Zhang H, He Z, Huang L, Yang CT.   +14 more
europepmc   +3 more sources

2H-Thiopyran-2-thione sulfine, a compound for converting H₂S to HSOH/H₂S₂ and increasing intracellular sulfane sulfur levels. [PDF]

Nat Commun
Reactive sulfane sulfur species such as persulfides (RSSH) and H2S2 are important redox regulators and closely linked to H2S signaling. However, the study of these species is still challenging due to their instability, high reactivity, and the lack of ...
Cui Q, Shieh M, Pan TW, Nishimura A, Matsunaga T, Kelly SS, Xu S, Jung M, Ogata S, Morita M, Yoshitake J, Chen X, Robinson JR, Qian WJ, Nishida M, Akaike T, Xian M.   +16 more
europepmc   +4 more sources

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

, 2023
Abstract Cysteine-bound sulfane sulfur atoms in proteins have received much attention as key factors in cellular redox homeostasis. However, the role of sulfane sulfur in zinc regulation has been underinvestigated. We report here that cysteine-bound sulfane sulfur atoms serve as ligands to hold and release zinc ions in growth inhibitory factor (GIF ...
Yasuhiro Shinkai, Yunjie Ding, Toru Matsui, George Devitt, Masahiro Akiyama, Tang‐Long Shen, Motohiro Nishida, Tomoaki Ida, Takaaki Akaike, Sumeet Mahajan, Jon M. Fukuto, Yasuteru Shigeta, Yoshito Kumagai   +12 more
  +4 more sources

NO Generation from Nitrite at Zinc(II): Role of Thiol Persulfidation in the Presence of Sulfane Sulfur. [PDF]

ACS Org Inorg Au, 2023
Nitrite-to-NO transformation is of prime importance due to its relevance in mammalian physiology. Although such a one-electron reductive transformation at various redox-active metal sites (e.g., Cu and Fe) has been illustrated previously, the reaction at the [ZnII] site in the presence of a sacrificial reductant like thiol has been reported to be ...
Sahana T, Valappil AK, Amma ASPR, Kundu S.   +3 more
europepmc   +4 more sources

The multifaceted roles of sulfane sulfur species in cancer-associated processes

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2020
Sulfane sulfur species comprise a variety of biologically relevant hydrogen sulfide (H2S)-derived species, including per- and poly-sulfidated low molecular weight compounds and proteins. A growing body of evidence suggests that H2S, currently recognized as a key signaling molecule in human physiology and pathophysiology, plays an important role in ...
Karim Zuhra, Catarina S. Tomé, Elena Forte, João B. Vicente, Alessandro Giuffrè   +4 more
openalex   +5 more sources

New fluorescent probes for sulfane sulfurs and the application in bioimaging [PDF]

Chemical Science, 2013
A sulfane sulfur mediated benzodithiolone formation was developed. Based on this reaction, two fluorescent probes (SSP1 and SSP2) for the detection of sulfane sulfur species (persulfide, polysulfide, and elemental sulfur) were prepared and evaluated. The probes showed high selectivity and sensitivity to sulfane sulfurs.
Wei Chen, Chunrong Liu, Bo Peng, Yu Zhao, Armando Pacheco, Ming Xian   +5 more
openalex   +5 more sources

Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in Corynebacterium glutamicum. [PDF]

Appl Environ Microbiol, 2023
Du H, Qi Y, Qiao J, Li L, Wei L, Xu N, Shao L, Liu J.   +7 more
europepmc   +3 more sources

Structural Basis for the Oxidation of Protein-bound Sulfur by the Sulfur Cycle Molybdohemo-Enzyme Sulfane Dehydrogenase SoxCD [PDF]

Journal of Biological Chemistry, 2010
The sulfur cycle enzyme sulfane dehydrogenase SoxCD is an essential component of the sulfur oxidation (Sox) enzyme system of Paracoccus pantotrophus. SoxCD catalyzes a six-electron oxidation reaction within the Sox cycle. SoxCD is an α(2)β(2) heterotetrameric complex of the molybdenum cofactor-containing SoxC protein and the diheme c-type cytochrome ...
U. Zander, Annette Faust, B.U. Klink, Daniele de Sanctis, Santosh Panjikar, Armin Quentmeier, Frank Bardischewsky, Cornelius G. Friedrich, Axel J. Scheidig   +8 more
openalex   +6 more sources

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease. [PDF]

Redox Biol, 2018
Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial respiration.
Rajpal S, Katikaneni P, Deshotels M, Pardue S, Glawe J, Shen X, Akkus N, Modi K, Bhandari R, Dominic P, Reddy P, Kolluru GK, Kevil CG.   +12 more
europepmc   +5 more sources

Optimization of a Method for Detecting Intracellular Sulfane Sulfur Levels and Evaluation of Reagents That Affect the Levels in Escherichia coli. [PDF]

Antioxidants (Basel), 2022
Sulfane sulfur is a class of compounds containing zero-valent sulfur. Most sulfane sulfur compounds are reactive and play important signaling roles. Key enzymes involved in the production and metabolism of sulfane sulfur have been characterized; however,
Yu Q, Ran M, Yang Y, Liu H, Xun L, Xia Y.   +5 more
europepmc   +2 more sources