Results 171 to 180 of about 22,801 (226)
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Current Opinion in Genetics and Development, 1997
During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
Giancarlo Parenti, Andrea Ballabio
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During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
Giancarlo Parenti, Andrea Ballabio
exaly +6 more sources
Lysosomal sulfatases: a growing family
Biochemical Journal, 2020Sulfatases constitute a family of enzymes that specifically act in the hydrolytic degradation of sulfated metabolites by removing sulfate monoesters from various substrates, particularly glycolipids and glycosaminoglycans. A common essential feature of all known eukaryotic sulfatases is the posttranslational modification of a critical cysteine residue ...
Lübke, Torben, Damme, Markus
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Journal of Steroid Biochemistry, 1974
The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
O.V. DOMÍNGUEZ +3 more
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The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
O.V. DOMÍNGUEZ +3 more
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2005
Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Annual Review of Genomics and Human Genetics, 2005
▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
DIEZ ROUX G., BALLABIO, ANDREA
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▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
DIEZ ROUX G., BALLABIO, ANDREA
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Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase
Biochemical and Biophysical Research Communications, 1988Glucosamine-6-sulfatase is a lysosomal enzyme which degrades glycosaminoglycans and is deficient in mucopolysaccharidosis type IIID. Human liver contains two major active forms of glucosamine-6-sulfatase, form A which has a single 78 kDa polypeptide and form B which has two polypeptides of 48 kDa and 32 kDa.
D A, Robertson +4 more
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Developmental regulation of choline sulfatase and aryl sulfatase in Neurospora crassa
Archives of Biochemistry and Biophysics, 1974Abstract Regulation of the synthesis of several enzymes of sulfur metabolism in Neurospora is a function of both metabolic regulation and the genetic control exerted by the cys -3 and scon regulatory genes. Additional control mechanisms appear to regulate the synthesis of choline sulfatase and aryl sulfatase in different developmental stages of ...
W G, McGuire, G A, Marzluf
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Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors
The Journal of Steroid Biochemistry and Molecular Biology, 1996About one-third of breast cancers are classified as estrogen-dependent breast cancers. In the past 10 years, numerous reports have suggested the importance of estrone sulfate and estrone sulfatase in regulating the supply of estrogens to these cancers. Estrone sulfatase inhibitors may thus prove to be useful for the treatment of these diseases. Several
P K, Li +3 more
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1987
Publisher Summary This chapter discusses the sulfatases from Helix pomatia. Sulfate esters are common metabolites, and their characterization can be aided by the use of a homogeneous, or highly purified, sulfatase of broad specificity as a hydrolyzing agent. The highly specific mammalian arylsulfatases are not suitable.
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Publisher Summary This chapter discusses the sulfatases from Helix pomatia. Sulfate esters are common metabolites, and their characterization can be aided by the use of a homogeneous, or highly purified, sulfatase of broad specificity as a hydrolyzing agent. The highly specific mammalian arylsulfatases are not suitable.
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NIPPON KAGAKU KAISHI, 1941
アルドール硫酸もヒドラヂンにより分解される.それ故,ヒドラヂンにより分解される現象は還元糖の硫酸エステルに限らず,還元基を有する多くの硫酸エステルに廣く認められるのであらう.アラビノーゼ硫酸のヒドラヂンによる分解速度を種々の條件の下で測定した.
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アルドール硫酸もヒドラヂンにより分解される.それ故,ヒドラヂンにより分解される現象は還元糖の硫酸エステルに限らず,還元基を有する多くの硫酸エステルに廣く認められるのであらう.アラビノーゼ硫酸のヒドラヂンによる分解速度を種々の條件の下で測定した.
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