Results 101 to 110 of about 14,179 (284)

Elucidation of Proteoforms of Chinese Hamster Ovary (CHO) Phospholipase B‐Like 2 (PLBL2) Captured From a Monoclonal Antibody

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 406-419, February 2026.
A platform approach to the affinity capture and enrichment of host cell proteins to enable their subsequent deep characterization and elucidation of variants or proteoforms (e.g., molecular size variants, charge variants, glycoforms, etc.). ABSTRACT Removing host cell proteins (HCPs) during biotherapeutic manufacturing is essential to ensure patient ...
Michael E. Dolan, Lei (Leo) Wang, Alexander Tedeschi, Yan Wang, Christopher Barton, Sheldon F. Oppenheim, Zhaohui Sunny Zhou   +6 more
wiley   +1 more source

Sulfatases and a Radical S-Adenosyl-l-methionine (AdoMet) Enzyme Are Key for Mucosal Foraging and Fitness of the Prominent Human Gut Symbiont, Bacteroides thetaiotaomicron*

Journal of Biological Chemistry, 2011
The large-scale application of genomic and metagenomic sequencing technologies has yielded a number of insights about the metabolic potential of symbiotic human gut microbes.
A. Benjdia, E. Martens, J. Gordon, O. Berteau   +3 more
semanticscholar   +1 more source

Research and Application of Chondroitin Sulfate/Dermatan Sulfate-Degrading Enzymes

Frontiers in Cell and Developmental Biology, 2020
Chondroitin sulfate (CS) and dermatan sulfate (DS) are widely distributed on the cell surface and in the extracellular matrix in the form of proteoglycan, where they participate in various biological processes.
Wenshuang Wang, Liran Shi, Yong Qin, Fuchuan Li   +3 more
doaj   +1 more source

ErbB2 Dephosphorylation and Anti-Proliferative Effects of Neuregulin-1 in ErbB2-Overexpressing Cells; Re-evaluation of Their Low-Affinity Interaction [PDF]

, 2013
Neuregulin-1 binds to ErbB3 and ErbB4 and regulates cancer proliferation and differentiation. Neuregulin-1 had been suggested to also react with ErbB2, but this argument becomes controversial.
Araki Kazuaki, Higashiyama Shigeki, Iwakura Yuriko, Keino-Masu Kazuko, Masu Masayuki, Nawa Hiroyuki, Takei Nobuyuki, Wang Ran, Wang Xue-yi, 桝 和子, 桝 正幸   +10 more
core   +1 more source

Pathogenic Variants in Mennonites From Southern Brazil: Implications for Preventive Measures in Public Health

Clinical Genetics, Volume 109, Issue 2, Page 266-276, February 2026.
In 325 exomes of South Brazilian Mennonites, we identified 23 pathogenic variants (P) and 27 likely P, with founder effects identified for 96% of P, whose frequencies differed from non‐Finnish Europeans, Amish, and Brazilian populations. ABSTRACT The Mennonite population has a unique history of 500 years of genetic isolation shaped by at least three ...
Luiza Beatriz Mayer de Lima, Eduardo Delabio Auer, Isabela Dall’Oglio Bucco, Valéria Bumiller‐Bini Hoch, Priscila Ianzen dos Santos, Fabiana L. Lopes, Alan Shuldiner, Emilton Lima Júnior, Angelica Beate Winter Boldt   +8 more
wiley   +1 more source

Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice*

Journal of Biological Chemistry, 2012
Background: Extracellular endosulfatases Sulf1 and Sulf2 hydrolyze 6-O-sulfate in heparan sulfate. Results: Disaccharide analysis showed that 2-O-, 6-O-, and N-trisulfated disaccharide units in heparan sulfate were increased to different degrees in ...
S. Nagamine, M. Tamba, H. Ishimine, Kota Araki, Kensuke Shiomi, T. Okada, T. Ohto, S. Kunita, Satoru Takahashi, R. Wismans, T. V. van Kuppevelt, M. Masu, K. Keino‐Masu   +12 more
semanticscholar   +1 more source

Structural Basis of Mucopolysaccharidosis Type II and Construction of a Database of Mutant Iduronate 2-Sulfatases. [PDF]

PLoS ONE, 2016
Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is an X-linked genetic disorder caused by a deficiency of iduronate 2-sulfatase (IDS), and missense mutations comprising about 30% of the mutations responsible for MPS II result in heterogeneous ...
Seiji Saito, Kazuki Ohno, Torayuki Okuyama, Hitoshi Sakuraba   +3 more
doaj   +1 more source

RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins [PDF]

, 2016
The sea urchin larval skeleton offers a simple model for formation of developmental patterns. The calcium carbonate skeleton is secreted by primary mesenchyme cells (PMCs) in response to largely unknown patterning cues expressed by the ectoderm.
Bardot, Evan, Blute, Todd A., Bradham, Cynthia A., Chaves, James, Chung, Oliver, Core, Amanda B., Coulombe-Huntington, Jasmin, Ferrell, Patrick, Fishman, Julie, Hameeduddin, Hajerah, Hewitt, Finnegan B., Hogan, John D., Ibn-Salem, Jonas, Keenan, Jessica L, Lee, David, Li, Christy, Luo, Lingqi, Oleinik, Ekaterina, Patel, Vijeta, Piacentino, Michael L., Poustka, Albert J., Ramachandran, Janani, Reyna, Arlene, Rose, Sviatlana, Speranza, Emily E., Yu, Jia, Zuch, Daniel T.   +26 more
core   +1 more source

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Uncovering the molecular mechanisms of lignocellulose digestion in shipworms [PDF]

, 2018
Lignocellulose forms the structural framework of woody plant biomass and represents the most abundant carbon source in the biosphere. Turnover of woody biomass is a critical component of the global carbon cycle, and the enzymes involved are of increasing
Bates, Rachel, Besser, Katrin, Bruce, Neil Charles, Cragg, Simon M., Dowle, Adam, Elias, Luisa, Li, Yi, McQueen Mason, Simon John, Pesante, Giovanna, Rathbone, Deborah Ann, Sabbadin, Federico, Shipway, J Reuben, Stark, Meg, Steele-King, Clare G.   +13 more
core   +3 more sources