Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases [PDF]
Biochemistry, 2020 Phase II drug metabolism inactivates xenobiotics and endobiotics through the addition of either a glucuronic acid or sulfate moiety prior to excretion, often via the gastrointestinal tract.
Samantha M Ervin +2 more
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NIPPON KAGAKU KAISHI, 1942 アルドール硫酸もヒドラヂンにより分解される.それ故,ヒドラヂンにより分解される現象は還元糖の硫酸エステルに限らず,還元基を有する多くの硫酸エステルに廣く認められるのであらう.アラビノーゼ硫酸のヒドラヂンによる分解速度を種々の條件の下で測定した.
Fujio Egami
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Identification and Signature Sequences of Bacterial Δ4,5Hexuronate-2-O-Sulfatases
Frontiers in Microbiology, 2019 Glycosaminoglycan (GAG) sulfatases, which catalyze the hydrolysis of sulfate esters from GAGs, belong to a large and conserved sulfatase family. Bacterial GAG sulfatases are essential in the process of sulfur cycling and are useful for the structural ...
Shumin Wang +4 more
doaj +2 more sources
Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP [PDF]
Cancer Biology & TherapyThe highest incidence and cancer-related mortality rate among women worldwide is due to breast cancer. Triple-negative breast cancers (TNBC) are associated with more inferior outcomes than other breast cancers because of their progressive nature and the ...
Jasmine M. Manouchehri +12 more
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Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series [PDF]
Communications MedicineBackground Multiple sulfatase deficiency (MSD) is an exceptionally rare neurodegenerative disorder due to the absence or deficiency of 17 known cellular sulfatases.
Nishitha R. Pillai +12 more
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Human Sulfatase 2 inhibits
BMC Cancer, 2010 Background Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state.
Peterson Sarah M +11 more
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Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship [PDF]
Human Molecular Genetics, 2005 Sulfatases catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates. Several human inherited diseases are caused by the deficiency of individual sulfatases, while in patients with multiple sulfatase deficiency mutations in the Sulfatase Modifying Factor 1 (SUMF1) gene cause a defect in the post-translational modification of a ...
SARDIELLO M. +3 more
openaire +5 more sources
Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma [PDF]
Discover OncologySulfatases mediate the sulfation level of cell-surface heparan sulfates to regulate signal transduction, thereby promoting cancer progression. Sulfatase activation requires a sulfatase modifying factor (SUMF) for the modification of its catalytic domain.
Wei-Ting Kuo +4 more
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Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity
Frontiers in Microbiology, 2019 Chondroitin sulfate/dermatan sulfate (CS/DS) sulfatases are potential tools for structural and functional studies of CD/DS chains. In our previous study, a CS/DS 4-O-endosulfatase (endoVB4SF) was identified from a marine bacterium (Wang et al., 2015 ...
Shumin Wang +6 more
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Frontiers in Oncology, 2014 Heparan sulfate proteoglycans (HSPGs) are an integral and dynamic part of normal tissue architecture at the cell surface and within the extracellular matrix (ECM).
Edward eHammond +3 more
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