Results 11 to 20 of about 5,662 (212)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Steroid Sulfatase Deficiency [PDF]

Pediatric Research, 1977
Placental steroid sulfatase deficiency is a genetic disorder only recently reported in the medical literature. Most documented cases of placental sulfatase deficiency have been marked by delay in onset of labor, lack of cervical dilatation, and relative refractoriness of oxytocic agents and amniotomy. We have studied the placenta, cultured fibroblasts,
L J, Shapiro, L, Cousins, A L, Fluharty, R L, Stevens, H, Kihara   +4 more
openaire   +2 more sources

Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. [PDF]

PLoS ONE, 2013
The genome of Mycobacterium tuberculosis (Mtb) encodes nine putative sulfatases, none of which have a known function or substrate. Here, we characterize Mtb's single putative type II sulfatase, Rv3406, as a non-heme iron (II) and α-ketoglutarate ...
Kimberly M Sogi, Zev J Gartner, Mark A Breidenbach, Mason J Appel, Michael W Schelle, Carolyn R Bertozzi   +5 more
doaj   +1 more source

Heparan Sulfate: A Regulator of White Adipocyte Differentiation and of Vascular/Adipocyte Interactions

Biomedicines, 2022
White adipose tissues are major endocrine organs that release factors, termed adipokines, which affect other major organ systems. The development and functions of adipose tissues depend largely upon the glycosaminoglycan heparan sulfate.
J. Michael Sorrell, Arnold I. Caplan
doaj   +1 more source

Multiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs. [PDF]

Proceedings of the National Academy of Sciences, 1992
Multiple sulfatase deficiency (MSD) is an inherited lysosomal storage disease characterized by the deficiency of at least seven sulfatases. The basic defect in MSD is thought to be in a post-translational modification common to all sulfatases. In accordance with this concept, RNAs of normal size and amount were detected in MSD fibroblasts for three ...
Rommerskirch, Winfried, Figura, Kurt von
openaire   +3 more sources

Purification, Characterization, and Structural Studies of a Sulfatase from Pedobacter yulinensis

Molecules, 2021
Sulfatases are ubiquitous enzymes that hydrolyze sulfate from sulfated organic substrates such as carbohydrates, steroids, and flavones. These enzymes can be exploited in the field of biotechnology to analyze sulfated metabolites in humans, such as ...
Caleb R. Schlachter, Andrea O’Malley, Linda L. Grimes, John J. Tomashek, Maksymilian Chruszcz, L. Andrew Lee   +5 more
doaj   +1 more source

Revisiting Hyaluronan Catabolism in Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy. [PDF]

Microbiologyopen
Hyaluronan degradation in Bacteroides cannot be reliably predicted from canonical PL8/GH88 enzymes alone. Experimental validation reveals coordinated induction of noncanonical accessory proteins (BT4410/BT4411), highlighting pathway plasticity and context‐dependent glycosaminoglycan utilization. ABSTRACT The ability of gut microbes to degrade host‐ and
Sindelar M, Kocurkova A, Simek M, Roudnicky P, Ambrozova G, Kubala L, Turkova K.   +6 more
europepmc   +2 more sources

Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency

Frontiers in Cell and Developmental Biology, 2022
Multiple sulfatase deficiency (MSD) is a rare recessively inherited Mendelian disorder that manifests with developmental delay, neurodegeneration, skeletal deformities, facial dysmorphism, congenital growth retardation, and other clinical signs.
Angeleen Fleming, Angeleen Fleming, Angeleen Fleming, Low Zhe Xuan, Gentzane Sanchez-Elexpuru, Gentzane Sanchez-Elexpuru, Gentzane Sanchez-Elexpuru, Sarah V. Williams, Sarah V. Williams, Sarah V. Williams, Dylan Windell, Dylan Windell, Dylan Windell, Michael H. Gelb, Zackary M. Herbst, Lars Schlotawa, David C. Rubinsztein, David C. Rubinsztein   +17 more
doaj   +1 more source

Fucoidan Sulfatases from Marine Bacterium Wenyingzhuangia fucanilytica CZ1127T

Biomolecules, 2018
Fucoidans belong to a structurally heterogeneous class of sulfated polysaccharides isolated from brown algae. They have a wide spectrum of biological activities.
Artem S. Silchenko, Anton B. Rasin, Anastasiya O. Zueva, Mikhail I. Kusaykin, Tatiana N. Zvyagintseva, Anatoly I. Kalinovsky, Valeriya V. Kurilenko, Svetlana P. Ermakova   +7 more
doaj   +1 more source

Alkyl Sulfatase of Cholera Vibrios

Проблемы особо опасных инфекций, 2023
The aim of the work was to study the structure of the alkyl sulfatase (asu) gene in Vibrio cholerae strains of various serogroups, as well as to compare nucleotide and amino acid sequences of alkyl sulfatases using various methods of bioinformatic ...
O. V. Duvanova, O. A. Podoinitsyna, R. V. Pisanov, S. O. Vodop’yanov, A. S. Vodop’yanov, E. S. Shipko, V. D. Kruglikov, O. S. Chemisova, A. K. Noskov   +8 more
doaj   +1 more source