Results 21 to 30 of about 3,139 (183)

MaAts, an Alkylsulfatase, Contributes to Fungal Tolerances against UV-B Irradiation and Heat-Shock in Metarhizium acridum

Journal of Fungi, 2022
Sulfatases are commonly divided into three classes: type I, type II, and type III sulfatases. The type III sulfatase, alkylsulfatase, could hydrolyze the primary alkyl sulfates, such as sodium dodecyl sulfate (SDS) and sodium octyl sulfate.
Lei Song, Xiaoning Xue, Shuqin Wang, Juan Li, Kai Jin, Yuxian Xia   +5 more
doaj   +1 more source

Recognition and ER Quality Control of Misfolded Formylglycine-Generating Enzyme by Protein Disulfide Isomerase

Cell Reports, 2018
Summary: Multiple sulfatase deficiency (MSD) is a fatal, inherited lysosomal storage disorder characterized by reduced activities of all sulfatases in patients.
Lars Schlotawa, Michaela Wachs, Olaf Bernhard, Franz J. Mayer, Thomas Dierks, Bernhard Schmidt, Karthikeyan Radhakrishnan   +6 more
doaj   +1 more source

Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. [PDF]

PLoS ONE, 2007
Heparan sulfate proteoglycans (HSPGs) are control elements in Wnt signaling, which bind extracellularly to Wnt ligands and regulate their ability to interact with signal transduction receptors on the cell surface.
Roman Nawroth, Annemieke van Zante, Sara Cervantes, Michael McManus, Matthias Hebrok, Steven D Rosen   +5 more
doaj   +1 more source

SUMF1 enhances sulfatase activitiesin vivoin five sulfatase deficiencies [PDF]

Biochemical Journal, 2007
Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the accumulation of either GAGs (glycosaminoglycans) or sulfolipids. The catalytic activity of sulfatases resides in a unique formylglycine residue in their active site generated by the post-translational ...
FRALDI, ALESSANDRO, A. Biffi, A. Lombardi, I. Visigalli, S. Pepe, SETTEMBRE, CARMINE, E. Nusco, AURICCHIO, ALBERTO, L. Naldini, BALLABIO, ANDREA, M. P. C.o.s.m.a.   +10 more
openaire   +4 more sources

Anaerobic Degradation of Sulfated Polysaccharides by Two Novel Kiritimatiellales Strains Isolated From Black Sea Sediment

Frontiers in Microbiology, 2019
The marine environment contains a large diversity of sulfated polysaccharides and other glycopolymers. Saccharolytic microorganisms degrade these compounds through hydrolysis, which includes the hydrolysis of sulfate groups from sugars by sulfatases ...
Daan M. van Vliet, Susakul Palakawong Na Ayudthaya, Susakul Palakawong Na Ayudthaya, Sally Diop, Laura Villanueva, Alfons J. M. Stams, Alfons J. M. Stams, Irene Sánchez-Andrea   +7 more
doaj   +1 more source

Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases

Angewandte Chemie, EarlyView.
We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong   +5 more
wiley   +2 more sources

Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts

BMC Cancer, 2010
Background Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state.
Peterson Sarah M, Iskenderian Andrea, Cook Lynette, Romashko Alla, Tobin Kristen, Jones Michael, Norton Angela, Gómez-Yafal Alicia, Heartlein Michael W, Concino Michael F, Liaw Lucy, Martini Paolo GV   +11 more
doaj   +1 more source

Detection of bacterial sulfatase activity through liquid- and solid-phase colony-based assays

AMB Express, 2017
Bacterial arylsulfatases are crucial to biosynthesis in many microorganisms, as bacteria often utilize aryl sulfates as a source of sulfur. The bacterial sulfatases are associated with pathogenesis and are applied in many areas such as industry and ...
Hey Young Yoon, Hyung Jun Kim, Soojin Jang, Jong-In Hong   +3 more
doaj   +1 more source

Design and Synthesis of 1-O- and 6′-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors

Frontiers in Chemistry, 2022
The extracellular human endo-6-O-sulfatases (Sulf-1 and Sulf-2) are responsible for the endolytic cleavage of the 6-sulfate groups from the internal D-glucosamine residues in the highly sulfated subdomains of heparan sulfate proteoglycans.
Kuei-Yao Tseng, Kuei-Yao Tseng, Zheng-Hao Tzeng, Ting-Jen Rachel Cheng, Pi-Hui Liang, Pi-Hui Liang, Shang-Cheng Hung, Shang-Cheng Hung, Shang-Cheng Hung   +8 more
doaj   +1 more source

Late infantile form of multiple sulfatase deficiency with a novel missense variant in the SUMF1 gene: case report and review

BMC Pediatrics, 2023
Background Multiple sulfatase deficiency (MSD) is a rare lysosomal storage disorder caused due to pathogenic variants in the SUMF1 gene. The SUMF1 gene encodes for formylglycine generating enzyme (FGE) that is involved in the catalytic activation of the ...
Jayesh Sheth, Siddharth Shah, Chaitanya Datar, Kaveri Bhatt, Pooja Raval, Aadhira Nair, Deepika Jain, Jhanvi Shah, Frenny Sheth, Harsh Sheth   +9 more
doaj   +1 more source