Results 11 to 20 of about 3,093 (180)

Matching the Diversity of Sulfated Biomolecules: Creation of a Classification Database for Sulfatases Reflecting Their Substrate Specificity. [PDF]

PLoS ONE, 2016
Sulfatases cleave sulfate groups from various molecules and constitute a biologically and industrially important group of enzymes. However, the number of sulfatases whose substrate has been characterized is limited in comparison to the huge diversity of ...
Tristan Barbeyron, Loraine Brillet-Guéguen, Wilfrid Carré, Cathelène Carrière, Christophe Caron, Mirjam Czjzek, Mark Hoebeke, Gurvan Michel   +7 more
doaj   +3 more sources

Sulfatases: Critical Enzymes for Algal Polysaccharide Processing

Frontiers in Plant Science, 2022
Microbial sulfatases are important biocatalysts in the marine environment where they play a key role in the catabolic biotransformation of abundant sulphated algal polysaccharides. The sulphate esters decorating algal polysaccharides, such as carrageenan,
Andrew G. Hettle, Chelsea J. Vickers, Alisdair B. Boraston   +2 more
doaj   +3 more sources

Fucoidan Sulfatases from Marine Bacterium Wenyingzhuangia fucanilytica CZ1127T

Biomolecules, 2018
Fucoidans belong to a structurally heterogeneous class of sulfated polysaccharides isolated from brown algae. They have a wide spectrum of biological activities.
Artem S. Silchenko, Anton B. Rasin, Anastasiya O. Zueva, Mikhail I. Kusaykin, Tatiana N. Zvyagintseva, Anatoly I. Kalinovsky, Valeriya V. Kurilenko, Svetlana P. Ermakova   +7 more
doaj   +3 more sources

Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series [PDF]

Communications Medicine
Background Multiple sulfatase deficiency (MSD) is an exceptionally rare neurodegenerative disorder due to the absence or deficiency of 17 known cellular sulfatases.
Nishitha R. Pillai, Ning Liu, Xiyuan Li, Xiqi Li, Rebecca Ahrens-Nicklas, Laura Adang, Julie B. Eisengart, Grace Bronken, Ashish Gupta, Troy C. Lund, Chester B. Whitley, Sarah H. Elsea, Paul J. Orchard   +12 more
doaj   +2 more sources

Identification of Multiple Sulfatase Deficiency (MSD) in newborn screening: A case study [PDF]

Molecular Genetics and Metabolism Reports
A patient with multiple sulfatase deficiency (MSD) was identified through a lysosomal storage disorder enzyme analysis panel, based on a characteristic pattern of reduced activities across multiple sulfatases.
Taraka R. Donti, James C. DiPerna, Madhuri R. Hegde   +2 more
doaj   +2 more sources

Phylogeny of algal sequences encoding carbohydrate sulfotransferases, formylglycine-dependent sulfatases and putative sulfatase modifying factors

Frontiers in Plant Science, 2015
Many algae are rich sources of sulfated polysaccharides with biological activities. The physicochemical/rheological properties and biological activities of sulfated polysaccharides are affected by the pattern and number of sulfate moieties.
Chai-Ling eHo
doaj   +3 more sources

Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma [PDF]

Discover Oncology
Sulfatases mediate the sulfation level of cell-surface heparan sulfates to regulate signal transduction, thereby promoting cancer progression. Sulfatase activation requires a sulfatase modifying factor (SUMF) for the modification of its catalytic domain.
Wei-Ting Kuo, Yi-Chen Lee, Jia-Bin Liao, Ching-Jiunn Tseng, Yi-Fang Yang   +4 more
doaj   +2 more sources

Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model [PDF]

Communications Medicine
Background Multiple Sulfatase Deficiency (MSD) is an ultra-rare autosomal recessive disorder characterized by deficient enzymatic activity of all known sulfatases. MSD patients frequently carry two loss of function mutations in the SUMF1 gene, encoding a
Maximiliano Presa, Vi Pham, Somdatta Ray, Pierre-Alexandre Piec, Jennifer Ryan, Timothy Billings, Harold Coombs, Lars Schlotawa, Troy Lund, Rebecca C. Ahrens-Nicklas, Cathleen Lutz   +10 more
doaj   +2 more sources

The Role of Sulfation in Nematode Development and Phenotypic Plasticity

Frontiers in Molecular Biosciences, 2022
Sulfation is poorly understood in most invertebrates and a potential role of sulfation in the regulation of developmental and physiological processes of these organisms remains unclear. Also, animal model system approaches did not identify many sulfation-
Catia Igreja, Ralf J. Sommer
doaj   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source