Results 31 to 40 of about 3,093 (180)

Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer

Frontiers in Oncology, 2021
Pancreatic cancer is a lethal condition with poor outcomes and an increasing incidence. The unfavourable prognosis is due to the lack of early symptoms and consequent late diagnosis.
Simone Furini, Chiara Falciani
doaj   +1 more source

SUMF1 enhances sulfatase activitiesin vivoin five sulfatase deficiencies [PDF]

Biochemical Journal, 2007
Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the accumulation of either GAGs (glycosaminoglycans) or sulfolipids. The catalytic activity of sulfatases resides in a unique formylglycine residue in their active site generated by the post-translational ...
FRALDI, ALESSANDRO, A. Biffi, A. Lombardi, I. Visigalli, S. Pepe, SETTEMBRE, CARMINE, E. Nusco, AURICCHIO, ALBERTO, L. Naldini, BALLABIO, ANDREA, M. P. C.o.s.m.a.   +10 more
openaire   +4 more sources

Severe neonatal multiple sulfatase deficiency presenting with hydrops fetalis in a preterm birth patient

JIMD Reports, 2019
Multiple sulfatase deficiency (MSD) is an ultra‐rare lysosomal storage disorder (LSD). Mutations in the SUMF1 gene encoding the formylglycine generating enzyme (FGE) result in an unstable FGE protein with reduced enzymatic activity, thereby affecting the
Lars Schlotawa, Thomas Dierks, Sophie Christoph, Eva Cloppenburg, Andreas Ohlenbusch, G. Christoph Korenke, Jutta Gärtner   +6 more
doaj   +1 more source

Balanços metabólicos do enxofre em pacientes com leucodistrofia metacromática

Arquivos de Neuro-Psiquiatria, 1968
Foram estudados os balanços metabólicos do enxofre em dois pacientes com a forma juvenil da leucodistrofia metacromática. Foi verificado, em ambos os casos, um balanço positivo desse metaloide, aparentemente não influenciado pelo tipo de dieta (geral ou ...
Horacio M. Canelas, Francisco B. de Jorge, Waldir A. Tognola   +2 more
doaj   +1 more source

Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma

Case Reports in Pediatrics, 2021
Multiple sulfatase deficiency (MSD) (MIM # 272200) is an extraordinarily rare inborn error of metabolism (IEM). The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known
Lorna Hirst, Gehan Abou-Ameira, Mari-Liis Uudelepp   +2 more
doaj   +1 more source

Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP

Cancer Biology & Therapy
The highest incidence and cancer-related mortality rate among women worldwide is due to breast cancer. Triple-negative breast cancers (TNBC) are associated with more inferior outcomes than other breast cancers because of their progressive nature and the ...
Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Daniel Stover, Ramesh K. Ganju, Bhuvaneswari Ramaswamy, William E. Carson, Arjun Mittra, Xiaoli Zhang, Patrick M. Schnell, Yu Yue, Mark P. Rubinstein, Mathew A. Cherian   +12 more
doaj   +1 more source

The Critical Role of Fractionated Urine Glycosaminoglycans in the Evaluation of Mucopolysaccharidosis Type II in Four Unrelated Families

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Since 2015, Ann and Robert H. Lurie Children's Hospital has performed diagnostic testing for infants who screen positive for mucopolysaccharidosis type II (MPS II) on the Illinois newborn screen. Preliminary diagnostic testing includes measurement of plasma iduronate‐2‐sulfatase enzyme activity and urinary glycosaminoglycan analysis, followed ...
Carly A. Rasmussen, Monika Izdebski, Allison Paltzer, Rachel Hickey, Laura Pollard, Joshua Baker   +5 more
wiley   +1 more source

Proteoglycan desulfation: a critical step in oncogenesis?

Frontiers in Bioscience-Landmark, 2020
Proteoglycans are essential constituents of tissue- and organ microenvironments, modulating both the structural scaffolds that surround cells as well as signaling cues that determine cellular phenotype.
Vishal Singh, Ramray Bhat
doaj   +1 more source

Purple Urine Bag Syndrome [PDF]

Journal of Clinical and Diagnostic Research, 2015
Purple urine bag syndrome (PUBS) is a rare disorder seen in elderly persons, wherein the urinary bag and the tubing turn in to purple colour. It is usually seen in patients who are on urinary catheters for a long time.
NAUFAL RIZWAN TARAGANAR ABUBACKER, SENTHIL MANIKANDAN THIRUMANILAYUR JAYARAMAN, KANNAN R, MAGESH KUMAR SIVANESAN, RENU MATHEW   +4 more
doaj   +1 more source

Structure and functional genes associated with carbon, nitrogen, phosphorus, and sulfur cycling processes in periphyton: A comparison between natural and artificial rivers

River, EarlyView.
Network analysis of functional genes among prokaryotes, and eukaryotes in natural and artificial rivers. Abstract Periphyton in aquatic ecosystems plays vital roles in the elemental cycle process and is vulnerable to anthropogenic interference. However, few studies have explored the elemental cycles of carbon (C), nitrogen (N), phosphorus (P), and ...
Yulu Tian, Jiezhang Mo, Jiaxin Liu, Chenghao Li, Jiahua Guo   +4 more
wiley   +1 more source