Results 151 to 160 of about 12,077 (273)

Oxidative Damage, Energy Imbalance, and Behavioral Disruptions in Girardia tigrina Exposed to Treated Sewage Effluents

Environmental Toxicology, EarlyView.
ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas, Pedro H. Carvalho, Daniela de Melo e Silva, Carlos Gravato   +3 more
wiley   +1 more source

Beyond Nutrition: The Therapeutic Promise of Seaweed-Derived Polysaccharides Against Bacterial and Viral Threats. [PDF]

Mar Drugs
Pereira L, Valado A.
europepmc   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

Acta Crystallographica Section F, EarlyView.
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima, Chiemi Mishima-Tsumagari, Mayumi Sakata-Sakuta, Ryo Iwaoka, Kunihiko Iwamoto   +4 more
wiley   +1 more source

Supramolecules for Pathogen Inhibition: From Polymers to Self-Assembled Nanosystems. [PDF]

Acc Mater Res
Nie C, Zoister C, Ma G, Haag R.
europepmc   +1 more source

Hyaluronidase-inhibitory activities of glycosaminoglycans from Liparis tessellatus eggs [PDF]

, 2017
Choi, Byeong-Dae, Lim, Jae-Min, Mussatto, Solange Ines, Park, Seongha, Rohmah, Zuliyati, Ticar, Bernadeth F.   +5 more
core   +1 more source

Crystal structures of PCNA1 and PCNA2 from Aeropyrum pernix: implications for a distorted heterotrimeric sliding clamp

Acta Crystallographica Section F, EarlyView.
Crystal structures of A. pernix PCNA1 (1.60 Å resolution) and PCNA2 (2.17 Å resolution) are reported. High‐resolution analysis reveals a rare nonproline cis‐peptide bond in PCNA1 that may cause steric hindrance at the subunit interface, suggesting a distorted or symmetry‐broken heterotrimeric PCNA ring.Aeropyrum pernix is a hyperthermophilic archaeon ...
Tong Wang, Sonoko Ishino, Yoshizumi Ishino, Takuji Oyama   +3 more
wiley   +1 more source

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications. [PDF]

Chembiochem
Szekeres GP, Moon E, Elter JK, Roper B, Kizhakkedathu JNN, Ballauff M, Haag R, Pagel K.   +7 more
europepmc   +1 more source

Structural analysis of the flexibility of the Ubl2 domain within the papain‐like protease of SARS‐CoV‐2

Acta Crystallographica Section F, EarlyView.
The ubiquitin‐like domain 2 (Ubl2) of the SARS‐CoV‐2 virus is necessary for the stability and catalytic efficiency of its papain‐like protease (PLpro). Our crystallographic study reveals that the Ubl2 domain exhibits notable flexibility and can adopt a conformation that places itself away from the PLpro catalytic domain, representing a new conformation
Gian Luca Freiherr von Scholley, Martina Schaefer, Mark D. Tully, Marc-Andre Hograindleur, Montserrat Soler-López, Roman C. Hillig, Christoph Mueller-Dieckmann, Eaazhisai Kandiah   +7 more
wiley   +1 more source

Mediterranean Seaweed Polysaccharides: Insight into Chemical Structures, Applications, and Structure/Application Correlations. [PDF]

Mar Drugs
Fanina S, Casillo A, Corsaro MM.
europepmc   +1 more source

Structural insights into urocanate reductase using room‐temperature X‐ray crystallography

Acta Crystallographica Section D, EarlyView.
The active‐site dynamics of the microbial enzyme urocanate reductase were revealed by room‐temperature X‐ray crystallography.Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate‐bound versus product‐bound states.
Swati Aggarwal, Nitisha Gurav, Esko Oksanen, Karin Lindkvist-Petersson, Raminta Venskutonytė   +4 more
wiley   +1 more source