Results 11 to 20 of about 12,077 (273)
Engineering sulfonate group donor regeneration systems to boost biosynthesis of sulfated compounds
Nature Communications, 2023 Sulfonation as one of the most important modification reactions in nature is essential for many biological macromolecules to function. Development of green sulfonate group donor regeneration systems to efficiently sulfonate compounds of interest is ...
Ruirui Xu +8 more
doaj +1 more source
Acta Scientiarum: Biological Sciences, 2011 Sulfated polysaccharides (SPs) have attracted growing interest for various biotechnological applications. We evaluated the efficiency of two methods of drying SPs (M I and II) extracted from Halymenia sp Rhodophyceae in order to compare the yield ...
José Ariévilo Gurgel Rodrigues +5 more
doaj +3 more sources
Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways [PDF]
Journal of The Royal Society Interface, 2022 Phosphate and sulfate groups are integral to energy metabolism and introduce negative charges into biological macromolecules. One purpose of such modifications is to elicit precise binding/activation of protein partners. The physico-chemical properties of the two groups, while superficially similar, differ in one important respect—the valency of the ...
M. A. Lima +3 more
openaire +2 more sources
Marine Drugs, 2021 Sulfated galactans (SG) isolated from red alga Gracilaria fisheri have been reported to inhibit the growth of cholangiocarcinoma (CCA) cells, which was similar to the epidermal growth factor receptor (EGFR)-targeted drug, cetuximab.
Boonyakorn Boonsri +8 more
doaj +1 more source
Antimicrobial effect of a crude sulfated polysaccharide from the red seaweed Gracilaria ornata
Brazilian Archives of Biology and Technology, 2012 The aim of this study was to determine the yield, chemical composition, specific rotation (SR), infrared (IR) spectroscopy and the effect on bacterial growth of a crude sulfated polysaccharide (SP) from the red marine alga G. ornata (Go). Go-1 (25°C), Go-
Rodrigo das Neves dos Santos Amorim +6 more
doaj +1 more source
Evidence for the role of proteoglycans in cation-mediated gene transfer [PDF]
, 1996 We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Baldeschwieler, John D. +1 more
core +1 more source
Brazilian Archives of Biology and Technology, 2011 The aim of this study was to evaluate certain molecular characteristics of a sulfated polysaccharide (SPs) with anticoagulant properties, isolated from Caulerpa cupressoides (Chlorophyta).
José Ariévilo Gurgel Rodrigues +6 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2021 The updated “Unifying Hypothesis of Alzheimer’s disease” (AD) is described that links all the observed neuropathology in AD brain (i.e., plaques, tangles, and cerebrovascular amyloid deposits), as well as inflammation, genetic factors (involving ApoE ...
Alan David Snow +2 more
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End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans [PDF]
, 2010 Glycosaminoglycans are sulfated polysaccharides that play important roles in fundamental biological processes, such as cell division, viral invasion, cancer and neuroregeneration.
Brown, Joshua M. +6 more
core +2 more sources
Acta Scientiarum: Technology, 2011 Heparin (HEP) is known due to their side effects and the red seaweed Halymenia floresia (Hf) sulfated polysaccharides (SP) are heparinoids. In this study we purified the Hf-SP obtained from an aqueous extract and evaluated their anticoagulant activities.
José Ariévilo Gurgel Rodrigues +5 more
doaj +1 more source