The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
Ephrin-B1 regulates cell surface residency of heparan sulfate proteoglycans (HSPGs) and complexes with the HSPG CD44V3-10 and fibroblast growth factor receptors. [PDF]
GlycobiologyPrydz K, Simm R, Davydova E, Aasheim HC.
europepmc +1 more source
The FEBS Journal, EarlyView.The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami +6 more
wiley +1 more source
Secret heroes of the sea: brown macroalgae and their bioactive powers-a narrative review. [PDF]
Front NutrCan B, Sanlier N.
europepmc +1 more source
PEG400 regulates Falcipain 2 activity through an allosteric mechanism
The FEBS Journal, EarlyView.Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath +2 more
wiley +1 more source
Recent Progressions in Applications of Bioactive Polysaccharides in Food and Health Sciences: A Comprehensive Review. [PDF]
Food Sci NutrChaitanya MVNL +14 more
europepmc +1 more source
Fucose-containing sulfated polysaccharides from brown seaweed: Extraction technolgy and bioactivity assessment [PDF]
, 2012 Ale, Marcel Tutor
core
The FEBS Journal, EarlyView.Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner +8 more
wiley +1 more source
Sulfated Polysaccharides of <i>Potamogeton lucens</i> as a Promising Immunostimulatory Agent in Activation of RAW264.7 and NK Cells. [PDF]
Food Sci NutrCao R +6 more
europepmc +1 more source
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
The FEBS Journal, EarlyView.AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney +10 more
wiley +1 more source