Results 51 to 60 of about 12,077 (273)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heparanase-Dependent Remodeling of Initial Lymphatic Glycocalyx Regulates Tissue-Fluid Drainage During Acute Inflammation in vivo

Frontiers in Immunology, 2019
The glycocalyx is a dense layer of carbohydrate chains involved in numerous and fundamental biological processes, such as cellular and tissue homeostasis, inflammation and disease development.
Samantha Arokiasamy, Samantha Arokiasamy, Ross King, Hidayah Boulaghrasse, Robin N. Poston, Sussan Nourshargh, Wen Wang, Mathieu-Benoit Voisin   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Environment Recording Unit in coral skeletons – a synthesis of structural and chemical evidences for a biochemically driven, stepping-growth process in fibres [PDF]

Biogeosciences, 2005
This paper gathers a series of structural and biochemical in situ characterizations carried out to improve our knowledge of the fine scale growth patterns of fibres in coral skeletons.
J. P. Cuif, Y. Dauphin
doaj  

Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion. [PDF]

, 1982
We have examined the carbohydrate specificity of bindin, a sperm protein responsible for the adhesion of sea urchin sperm to eggs, by investigating the interaction of a number of polysaccharides and glycoconjugates with isolated bindin.
Glabe, CG, Grabel, LB, Rosen, SD, Vacquier, VD   +3 more
core  

Microassay for Sulfated Glycosaminoglycans by Alcian Blue Staining. Effects of Polyanionic Macromolecules on Staining in Untreated Biological Samples.

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology), 1998
グリコサミノグリカンは酢酸セルロース膜を用いた電気泳動によって分離の後アルシアンブルーによって検出されてきた。著者らはすでにアルシアンブルーと陰イオンを結合させる方法を用いてDNA, ヒアルロン酸, 牛血清アルブミンなどの他の陰性荷電物質の妨害を受けないで硫酸化グリコサミノグリカンを直接微量分析する方法を報告した。本研究の目的は生体液に存在する他の陰性荷電高分子物質が本法による硫酸化グリコサミノグリカンの直接分析を妨害しないかどうか検討することである。2μlのサンプルを酢酸セルロースのペーパーストリップスにしみこませ, これをpH1.5に調製した0.05M塩化マグネシウム, 0.4Mグアニジン塩酸, 0.02M硫酸, 0.25%トライトンX-100を含む0.2%アルシアンブルー溶液で染色した ...
Eiji Yamamoto, Yoshikatsu Kawabata, Yoshitada Kou, Kougorou Kawai, Masato Taniguchi, Tsukasa Takatori, Kenji Imai, Masafumi Shiraki, Yukio Iwayama   +8 more
openaire   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Sulfated Exopolysaccharides from Porphyridium purpureum: A Review of Extraction, Structural Characterization, and Chemical Properties for Advanced Applications [version 2; peer review: 2 approved]

F1000Research
Microalgae are increasingly recognized as sustainable green cell factories capable of producing a various high-value bioactive compounds. Among them, the red microalga Porphyridium purpureum stands out for its unique ability to secrete sulfated ...
Heri Setiawan, Devi Maulina, Abdul Mun’im, Asep Bayu, Najihah Mohd Hashim   +4 more
doaj   +1 more source

Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography [PDF]

, 1999
Flavobacterium heparinum is a soil bacterium that produces several mucopolysaccharidases such as heparinase, heparitinases I and II, and chondroitinases AC, B, C and ABC. The purpose of the present study was to optimize the preparation of F.
Aguiar, Jair Adriano Kopke, Michelacci, Yara Maria   +1 more
core   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source