Parallel evaluation of nucleophilic and electrophilic chemical probes for sulfenic acid: Reactivity, selectivity and biocompatibility [PDF]
Redox Biology, 2021 Cysteine sulfenic acids (Cys-SOH) are pivotal modifications in thiol-based redox signaling and central intermediates en route to disulfide and sulfinic acid states.
Yunlong Shi, Kate S. Carroll
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H2O2-Mediated Oxidative Stress Enhances Cystathionine γ-Lyase-Derived H2S Synthesis via a Sulfenic Acid Intermediate [PDF]
Antioxidants, 2021 Hydrogen sulfide (H2S), which is generated mainly by cystathionine γ-lyase (CSE) in the cardiovascular system, plays a pivotal role in a wide range of physiological and pathological processes.
Jun Wang +11 more
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Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines [PDF]
Pharmaceuticals, 2019 We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original ...
Paola Maria Bonaccorsi +5 more
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The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile. [PDF]
J Am Chem Soc, 2014 Nitrile hydratase (NHase) catalyzes the hydration of nitriles to their corresponding commercially valuable amides at ambient temperatures and physiological pH.
Martinez S +4 more
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Sulfenic acid chemistry, detection and cellular lifetime. [PDF]
Biochim Biophys Acta, 2014 Reactive oxygen species-mediated cysteine sulfenic acid modification has emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic acid in proteins is dictated by the local microenvironment and ability of antioxidants to reduce this modification.
Gupta V, Carroll KS.
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Measurement of protein sulfenic acid content. [PDF]
Curr Protoc Toxicol, 2008 AbstractProtein sulfenic acids are reactive, reversibly oxidized, cysteinyl residues with roles in redox catalysis and regulation. Detection and quantitation of these species in proteins is accomplished through chemical modification by reagents such as 7‐chloro‐4‐nitrobenzo‐2‐oxa‐1,3‐diazole (NBD chloride), 2‐nitro‐5‐thiobenzoate (TNB) or dimedone ...
Poole LB.
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Cysteine-based redox regulation and signalling in plants [PDF]
Frontiers in Plant Science, 2013 Living organisms are subjected to oxidative stress conditions which are characterized by the production of reactive oxygen (ROS), nitrogen (RNS) and sulfur (RSS) species.
Jérémy eCouturier +3 more
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Strained cycloalkynes as new protein sulfenic acid traps. [PDF]
J Am Chem Soc, 2014 Protein sulfenic acids are formed by the reaction of biologically relevant reactive oxygen species with protein thiols. Sulfenic acid formation modulates the function of enzymes and transcription factors either directly or through the subsequent formation of protein disulfide bonds.
Poole TH +5 more
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A mechanism for the disrupted redox regulation of vascular contractility during aging [PDF]
iScienceSummary: Vascular dysfunction contributes to aging-related phenotype, but mechanisms remain unclear. We propose that aging promotes a deregulated convergence between cellular redox processes and mechanoregulation.
Leonardo Y. Tanaka +19 more
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Insights into the Function of a Conserved Cys120 in Human Neuroglobin in Oxidative Stress Regulation of Breast Cancer Cells [PDF]
BiomoleculesHuman neuroglobin (Ngb) is a globin featuring a disulfide bond (Cys46–Cys55) and a redox-active cysteine residue (Cys120) and plays a dual role in cellular stress responses. In this study, we investigated how wild-type (WT) Ngb and its two mutants, C120S
Shu-Qin Gao +4 more
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