Results 91 to 100 of about 8,975 (219)

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Flavin-containing monooxygenases: mutations, disease and drug response [PDF]

, 2008
NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Pharmacological Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Phillips, IR, Shephard, EA
core   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, Volume 12, Issue 42, November 13, 2025.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

C8J_1298, a bifunctional thiol oxidoreductase of Campylobacter jejuni, affects Dsb (disulfide bond) network functioning.

PLoS ONE, 2020
Posttranslational generation of disulfide bonds catalyzed by bacterial Dsb (disulfide bond) enzymes is essential for the oxidative folding of many proteins. Although we now have a good understanding of the Escherichia coli disulfide bond formation system,
Anna Marta Banaś, Katarzyna Marta Bocian-Ostrzycka, Maciej Plichta, Stanisław Dunin-Horkawicz, Jan Ludwiczak, Jagoda Płaczkiewicz, Elżbieta Katarzyna Jagusztyn-Krynicka   +6 more
doaj   +1 more source

Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension [PDF]

, 2017
Objective: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesise that in PASMCs, serotonin induces
Harvey, Adam P., Hood, Katie Y., MacLean, Margaret R., Mair, Kirsty M., Montezano, Augusto C., Touyz, Rhian M.   +5 more
core   +2 more sources

Oxidative stress in wild‐derived and cultivated peanut genotypes caused by heat stress at flowering

Agronomy Journal, Volume 117, Issue 6, November/December 2025.
Abstract Peanut (Arachis hypogaea L.) is a globally important crop; however, its productivity is increasingly threatened by heat stress, exacerbated by global warming. Developing heat‐tolerant peanuts is crucial for sustainable production amidst rising temperatures.
Kelvin Jimmy Awori, Soraya Leal‐Bertioli, David Bertioli, Viktor Tishchenko, Gabrielle Alves Comitre, Cristiane Pilon   +5 more
wiley   +1 more source

Atmospheric chemistry of bioaerosols: heterogeneous and multiphase reactions with atmospheric oxidants and other trace gases. [PDF]

, 2016
Advances in analytical techniques and instrumentation have now established methods for detecting, quantifying, and identifying the chemical and microbial constituents of particulate matter in the atmosphere.
Estillore, Armando D, Grassian, Vicki H, Trueblood, Jonathan V   +2 more
core   +2 more sources

Influence of the Concentration of Different Amino Acids on the Corrosion Behavior of Mg Alloy AZ31—A Respirometric Study

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT In view of the potential use of Mg‐based materials as biodegradable metals in temporary implantation, it is important to study the role of different components of the biological environment on the corrosion behavior. This work focuses on the effect of selected amino acids and their concentrations on time‐dependent corrosion of Mg alloy AZ31 ...
M. P. Bruns, G. Schulze, M. G. Strebl, S. Virtanen   +3 more
wiley   +1 more source

Disulfide relays and phosphorylative cascades: Partners in redox-mediated signaling pathways [PDF]

, 2005
Modifications of specific amino-acid residues of proteins are fundamental in order to modulate different signaling processes among which the cascade of phosphorylation represents the most effective example.
A Delaunay, AA Akhand, D Barford, E Pineda-Molina, FQ Schafer, G Filomeni, G Filomeni, G Filomeni, G Filomeni, G Filomeni, G Georgiou, G Rotilio, G Rotilio, H Ichijo, H Kamata, H Nakamura, H Schroeter, HE Marshall, JD Helmann, JM McCord, K Takeda, LN Johnson, M R Ciriolo, M Saitoh, M Zheng, MR Jacquier-Sarlin, MS Paget, P Klatt, P Turella, S Kuge, SK Hanks, SO Kim, T Buschmann, T Finkel, T Finkel, T Hunter, T Pawson, V Adler, V Adler, WC Barrett, WM Toone, XZ Sun, Y Liu   +42 more
core   +1 more source

Oxidative denaturation of Cu/Zn‐superoxide dismutase associated with neurodegenerative diseases

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Misfolding of mutant Cu/Zn‐superoxide dismutase (SOD1) is a well‐established pathological feature of familial amyotrophic lateral sclerosis (ALS). While amino acid substitutions in mutant SOD1 destabilize its structure and promote misfolding, oxidation has also been implicated in the pathological alterations of wild‐type SOD1, particularly in ...
Moeno Yoshida, Norifumi Muraki, Michiko Tajiri, Kowit Hengphasatporn, Kaori Sue, Takehiro Kubo, Satoko Akashi, Yasuteru Shigeta, Taiho Kambe, Yoshiaki Furukawa   +9 more
wiley   +1 more source