Results 111 to 120 of about 8,975 (219)

Diametrically opposed effects of hypoxia and oxidative stress on two viral transactivators

Virology Journal, 2010
Background Many pathogens exist in multiple physiological niches within the host. Differences between aerobic and anaerobic conditions are known to alter the expression of bacterial virulence factors, typically through the conditional activity of ...
Aiyar Ashok, Singh Gyanendra, Washington Amber T   +2 more
doaj   +1 more source

Irreversible Thiol Oxidation in Carbonic Anhydrase III: Protection by S-Glutathiolation and Detection in Aging Rats [PDF]

, 2002
Proteins with reactive sulfhydryls are central to many important metabolic reactions and also contribute to a variety of signal transduction systems. In this re- port, we examine the mechanisms of oxidative dam- age to the two reactive sulfhydryls of ...
Hamann, Michael, Hendrich, Suzanne, Hendrich, Suzanne, Mallis, Robert, Thomas, James, Zhang, Tiequan, Zhao, Wei   +6 more
core   +3 more sources

A New Family of Membrane Electron Transporters and Its Substrates, Including a New Cell Envelope Peroxiredoxin, Reveal a Broadened Reductive Capacity of the Oxidative Bacterial Cell Envelope

mBio, 2012
The Escherichia coli membrane protein DsbD functions as an electron hub that dispatches electrons received from the cytoplasmic thioredoxin system to periplasmic oxidoreductases involved in protein disulfide isomerization, cytochrome c biogenesis, and ...
Seung-Hyun Cho, Derek Parsonage, Casey Thurston, Rachel J. Dutton, Leslie B. Poole, Jean-Francois Collet, Jon Beckwith   +6 more
doaj   +1 more source

Active focal segmental glomerulosclerosis is associated with massive oxidation of plasma albumin [PDF]

, 2007
The basic mechanism for idiopathic FSGS still is obscure. Indirect evidence in humans and generation of FSGS by oxidants in experimental models suggest a role of free radicals.
BRUSCHI M, CANDIANO G, CARIDI G, DEL BOCCIO P, DIMASI N, F. SCOLARI, GALLIANO M, GHIGGERI GM, MUSANTE L, PAVONE B, PETRETTO A, URBANI A, VINCENTI F   +12 more
core   +1 more source

Redox modulation of thimet oligopeptidase activity by hydrogen peroxide

FEBS Open Bio, 2017
Thimet oligopeptidase (EC 3.4.24.15, TOP) is a cytosolic mammalian zinc protease that can process a diversity of bioactive peptides. TOP has been pointed out as one of the main postproteasomal enzymes that process peptide antigens in the MHC class I ...
Marcelo Y. Icimoto, Juliana C. Ferreira, César H. Yokomizo, Larissa V. Bim, Alyne Marem, Joyce M. Gilio, Vitor Oliveira, Iseli L. Nantes   +7 more
doaj   +1 more source

Analyzing the Catalytic Mechanism of the Fe-Type Nitrile Hydratase from \u3cem\u3eComamonas testosteroni\u3c/em\u3e Ni1 [PDF]

, 2008
In order to gain insight into the catalytic mechanism of Fe-type nitrile hydratases (NHase), the pH and temperature dependence of the kinetic parameters kcat, Km, and kcat/Km along with the solvent isotope effect were examined for the Fe-type NHase from ...
Holz, Richard C., Rao, Saroja
core   +1 more source

Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin

Antioxidants
Hydrogen peroxide (H2O2) plays a crucial role in cell signaling in response to physiological and environmental perturbations. H2O2 can oxidize typical 2-Cys peroxiredoxin (PRX) first into a sulfenic acid, which resolves into a disulfide that can be ...
Shengnan Liu, Jingbo Pi, Qiang Zhang
doaj   +1 more source

JAC1 Promotes Thermotolerance in Arabidopsis by Limiting Heat-Induced H₂O₂ Accumulation and Protecting PGLP1 from Sulfenylation-Mediated Inhibition

Plants
Heat stress is a major constraint on plant growth and productivity, and excessive accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), especially hydrogen peroxide (H2O2), is a primary cause of heat-induced cellular damage ...
Binglei Zhang, Ruichao Li, Ke Li, Lihu Wang   +3 more
doaj   +1 more source

Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut

Signal Transduction and Targeted Therapy
Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights the importance of metabolic homeostasis in protecting against oxidative stress in the large ...
Xina Xiao, Meng Hu, Li Gao, Huan Yuan, Baochen Chong, Yu Liu, Rou Zhang, Yanqiu Gong, Dan Du, Yong Zhang, Hao Yang, Xiaohui Liu, Yan Zhang, Huiyuan Zhang, Heng Xu, Yi Zhao, Wenbo Meng, Dan Xie, Peng Lei, Shiqian Qi, Yong Peng, Tao Tan, Yang Yu, Hongbo Hu, Biao Dong, Lunzhi Dai   +25 more
doaj   +1 more source

Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function. [PDF]

Chem Res Toxicol, 2019
Li Z, Forshaw TE, Holmila RJ, Vance SA, Wu H, Poole LB, Furdui CM, King SB.   +7 more
europepmc   +1 more source