How are proteins reduced in the endoplasmic reticulum? [PDF]
, 2018 The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress has been made.
Bulleid, Neil +2 more
core +2 more sources
A Cobalt-Containing Eukaryotic Nitrile Hydratase [PDF]
, 2017 Nitrile hydratase (NHase), an industrially important enzyme that catalyzes the hydration of nitriles to their corresponding amides, has only been characterized from prokaryotic microbes. The putative NHase from the eukaryotic unicellular choanoflagellate
Bennett, Brian +3 more
core +1 more source
Structural basis of redox-dependent modulation of galectin-1 dynamics and function [PDF]
, 2014 Galectin-1 (Gal-1), a member of a family of multifunctional lectins, plays key roles in diverse biological processes including cell signaling, immunomodulation, neuroprotection and angiogenesis.
Caramelo, Julio Javier +6 more
core +4 more sources
Intracellular Monitoring of Luminescent Ag2S Nanoparticles in Fibroblasts
Advanced Optical Materials, Volume 13, Issue 35, December 12, 2025.This study investigates the long‐term luminescence behavior of Ag2S quantum dots (AS QDs) with three surface ligands (DTDTPA, 11MUA, PEG) in fibroblasts over 9 days. AS‐PEG showed stable uptake and enhanced NIR‐II emission, while others decreased due to oxidative stress.
Mahshid Hashemkhani +6 more
wiley +1 more source
Unraveling the Catalytic Mechanism of Nitrile Hydratases [PDF]
, 2007 To elucidate a detailed catalytic mechanism for nitrile hydratases (NHases), the pH and temperature dependence of the kinetic constants kcat and Km for the cobalt-type NHase from Pseudonocardia thermophila JCM 3095 (PtNHase) were examined.
Holz, Richard C., Mitra, Sanghamitra
core +1 more source
OH-Radical Specific Addition to Glutathione S-Atom at the Air–Water Interface: Relevance to the Redox Balance of the Lung Epithelial Lining Fluid [PDF]
, 2015 Antioxidants in epithelial lining fluids (ELF) prevent inhaled air pollutants from reaching lung tissue. This process, however, may upset ELF’s redox balance, which is deemed to be expressed by the ratio of the major antioxidant glutathione (GSH) to its ...
Colussi, Agustín J. +2 more
core +3 more sources
, 2014 Citation: 'sulfenic acids' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.S06096 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Identification of an Active Site-bound Nitrile Hydratase Intermediate through Single Turnover Stopped-flow Spectroscopy [PDF]
, 2013 Stopped-flow kinetic data were obtained for the iron-type nitrile hydratase from Rhodococcus equi TG328-2 (ReNHase) using methacrylonitrile as the substrate.
Gumataotao, Natalie +3 more
core +2 more sources
Multifunctional Fluorescent Microgel‐Embedded Hydrogels for Temperature and X‐Ray Sensing
Advanced Science, Volume 12, Issue 47, December 18, 2025.In this study, the application of a multifunctional fluorescent hydrogel based on AIE microgels, integrated with machine‐learning algorithms for the detection of temperature and X‐rays is prestented. This innovative platform not only simultaneously elevates temperature and X‐ray sensing performance but also preserves outstanding mechanical robustness ...
Hao Jiang +11 more
wiley +1 more source
Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress [PDF]
, 2014 Oxidative protein folding in the endoplasmic reticulum (ER) has emerged as a potentially significant source of cellular reactive oxygen species (ROS).
Kaiser, Chris +3 more
core +1 more source