Results 151 to 160 of about 49,136 (209)

Sulfhydryl Compounds May Mediate Gastric Cytoprotection

Science, 1981
Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F
S, Szabo, J S, Trier, P W, Frankel
openaire   +2 more sources

Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds

Journal of Cancer Research and Clinical Oncology, 1981
Urotoxic side effects, especially hemorrhagic cystitis, have so far been a limiting factor in the therapeutic use of cyclophosphamide (Endoxan), ifosfamide (Holoxan), and trofosfamide (Ixoten). The uroprotective agent mesna (Uromitexan) allows regional detoxification in the kidney and the urinary tract, and thus clinical prevention of the urotoxic side
N, Brock, J, Pohl, J, Stekar
openaire   +2 more sources

Protection of sulfhydryl compounds against ionizing radiation

Biochimica et Biophysica Acta, 1963
Cysteamine was shown to provide strong protection against x-ray inactivation of papain and of a small molecular compound, CoA, in solutions. The mechanism involved modification of their -SH groups. It is concluded that results are compatible with the hypothesis that the protection afforded by sulfhydryl compounds in vivo may be due in part to blocking ...
A, PIHL, T, SANNER
openaire   +2 more sources

Reaction of malformin with sulfhydryl compounds

Phytochemistry, 1970
Abstract Malformin reacts with the sulfhydryl compounds, cysteine and β-mercaptoethanol, to form an insoluble 1:1 addition product. This reaction may explain the ability of thiol compounds to inhibit the activity of malformin and suggests reaction of malformin with thiol compounds in vivo .
Shinobu Iriuchijima, Roy W. Curtis
openaire   +1 more source

Giant axonal neuropathy: studies with sulfhydryl donor compounds

Journal of the Neurological Sciences, 1990
Giant axonal neuropathy (GAN) is a disorder characterized pathologically by distal neurofilament-filled bulbous swellings in axons, and widespread collection of intermediate filaments, including masses of vimentin filaments in cultured skin fibroblasts.
R, Tandan, W G, Bradley, M J, Fillyaw
openaire   +2 more sources

Sulfhydryl Compounds as Thermosensitizers

1988
The cytotoxic effects of a number of widely used chemotherapeutic agents have been reported to be enhanced by heat (Hahn 1979; Hahn and Li 1982). The exact mechanism of this enhancement is not fully understood and might differ with the various compounds. Thermosensitization by sulfhydryl compounds in vitro has been observed by Kapp and Hahn (1979).
openaire   +2 more sources

Bioanalytical considerations for compounds containing free sulfhydryl groups

Biomedical Chromatography, 2003
AbstractThiol‐containing compounds pose bioanalytical challenge in several dimensions due to extreme reactivity of the sulfhydryl group. The development of robust bioanalytical methodology for thiol groups should address the aspects of adequate stabilization in the biological matrix and selectivity considerations.
Nuggehally R, Srinivas, Rao N V S, Mamidi   +1 more
openaire   +2 more sources

Incorporation of sulfhydryl compounds into melanins in vitro

Biochimica et Biophysica Acta (BBA) - General Subjects, 1988
Cysteine is known to be involved in pheomelanin synthesis. Available evidence, however, indicates that glutathione may also play an important role in melanogenesis. This in vitro study clarifies how cysteine and glutathione participate in melanogenesis.
S, Ito, Y, Imai, K, Jimbow, K, Fujita
openaire   +2 more sources

Enzymic methylation of foreign sulfhydryl compounds

Biochimica et Biophysica Acta, 1961
Abstract A new transmethylating enzyme system in mammalian tissues, catalyzing methyl transfer from S-adenosylmethionine to sulfhydryl compounds, has been studied. A series of “nonphysiological” sulfhydryl compounds (BAL, mercaptoethanol, O-methyl-mercaptoethanol, mercaptoacetic acid, β-mercaptoproprionic acid, methymercaptan and hydrogen sulfide ...
Jon Bremer, David M. Greenberg
openaire   +1 more source

The reduction of experimentally induced inflammation by sulfhydryl compounds

Biochemical Pharmacology, 1967
Abstract The sulfhydryl compounds acetylcysteine and acetylpenicillamine were found to reduce the severity of induced dermal inflammation in rabbits when the compounds were administered in repeated doses. Treatment with acetylcysteine and salicylate given concomitantly resulted in an anti-inflammatory response which was equal to that obtained with ...
K R, Bailey, A L, Sheffner
openaire   +2 more sources