Results 181 to 190 of about 68,767 (278)

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang   +5 more
wiley   +1 more source

Optimal Selenium Fertilizer Affects the Formation of Foxtail Millet (Setaria italica L.) Quality by Regulating Flavonoid Metabolism and Amino Acid Metabolism

open access: yesFood Science &Nutrition, Volume 13, Issue 6, June 2025.
S2 treatment regulated the flavonoid and histidine metabolism pathways of Jingu 21, reduced the protein content, increased the fat and starch contents, and decreased the peak viscosity and breakdown value. S2 treatment regulated the Stilbenoid, diarylheptanoid, and gingerol pathway of Jingu 40, and S3 treatment activated the tyrosine metabolic pathway ...
Shu Wang   +5 more
wiley   +1 more source

The microbiologist's guide to metaproteomics

open access: yesiMeta, Volume 4, Issue 3, June 2025.
Metaproteomics within the multi‐omics framework provides a comprehensive view of microbial systems by identifying proteins, quantifying their levels, detecting posttranslational modifications (PTMs), mapping protein–protein interactions (PPIs), and localizing proteins.
Tim Van Den Bossche   +31 more
wiley   +1 more source

Differences in storage stability of cow's milk-based and goat's milk-based infant formulas. [PDF]

open access: yesFood Chem X
Wan L   +9 more
europepmc   +1 more source

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

open access: yesiMeta, Volume 4, Issue 3, June 2025.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao   +9 more
wiley   +1 more source

In Vitro Validation of Pulsed Electromagnetic Field (PEMF) as an Effective Countermeasure Against Inflammatory‐Mediated Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
ABSTRACT Background Intervertebral disc (IVD) degeneration (IDD) is the main contributor to chronic low back pain (LBP), the leading cause of disability worldwide, with a significant impact on the quality of life and health of common people. The etiology of IDD is still unclear, but it has been largely demonstrated the crucial role of inflammation and ...
Laura Guarnaccia   +20 more
wiley   +1 more source

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