Results 81 to 90 of about 14,198 (193)

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

Post-genomic characterization of metabolic pathways in Sulfolobus solfataricus [PDF]

, 2012
The physiological functions and mode of actions of different biomolecules are of continuous interest and a prerequisite to fully understand and appreciate the potential of Archaea and their molecules.
Walther, J.
core  

Structural and Functional Characterisation of a Metagenome‐Derived CYP108D18 Reveals an Unusual Dioxygen‐Bound State and Selective Hydrocarbon Hydroxylation

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
CYP108D18, identified from a hot spring metagenome, catalyses selective phenylcyclohexane hydroxylation. This P450 has an exceptionally low substrate‐bound heme redox potential. Crystal structures revealed an unusual dioxygen‐bound substrate‐free form and a persistent open active site upon substrate binding.
Simran Kundral, Peter D. Giang, Alicia M. Kirk, Julia B. Buczynski, Kasun S. A. Arachchige, Sunil K. Khare, Paul V. Bernhardt, Paul N. Evans, Luke W. Guddat, Stephen G. Bell, James J. De Voss   +10 more
wiley   +1 more source

The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota

, 2005
Sulfolobus acidocaldarius is an aerobic thermoacidophilic crenarchaeon which grows optimally at 80 degrees C and pH 2 in terrestrial solfataric springs. Here, we describe the genome sequence of strain DSM639, which has been used for many seminal studies ...
Chen, L.M., Skovgaard, Marie, Klenk, Hans-Peter, Garrett, R.A., Chen, Lanming, She, Qunxin, Awayez, M., Klenk, H.P., Brügger, Kim, Brugger, K., She, Q.X., Redder, P., Zibat, A., Garrett, R. A., Awayez, Mariana J., Torarinsson, E., Greve, Bo Bjørn, Skovgaard, M., Greve, B., Redder, Peter Bastue   +19 more
core   +1 more source

Molecular Adaptations of Thermophilic Proteins—From Mechanistic Understanding to Machine Learning Approaches

ChemistryOpen, Volume 15, Issue 7, July 2026.
Several factors including hydrophobic packing, electrostatic interactions and hydrogen bonding influence thermostability of proteins. Mechanisms of thermal adaptation were investigated via structural and mutational studies. Stability predictions were enhanced by combining thermodynamic data with ML‐based computer models for protein engineering ...
Sermarajan Arunachalam, Balamurali MM, Ramachandran Gnanasekaran   +2 more
wiley   +1 more source

Crenarchaeal biofilm formation under extreme conditions. [PDF]

PLoS ONE, 2010
BACKGROUND: Biofilm formation has been studied in much detail for a variety of bacterial species, as it plays a major role in the pathogenicity of bacteria.
Andrea Koerdt, Julia Gödeke, Jürgen Berger, Kai M Thormann, Sonja-Verena Albers   +4 more
doaj   +1 more source

Interplay of Various Evolutionary Modes in Genome Diversification and Adaptive Evolution of the Family Sulfolobaceae

Frontiers in Microbiology, 2021
Sulfolobaceae family, comprising diverse thermoacidophilic and aerobic sulfur-metabolizing Archaea from various geographical locations, offers an ideal opportunity to infer the evolutionary dynamics across the members of this family.
Rachana Banerjee, Narendrakumar M. Chaudhari, Abhishake Lahiri, Abhishake Lahiri, Anupam Gautam, Anupam Gautam, Debaleena Bhowmik, Debaleena Bhowmik, Chitra Dutta, Sujay Chattopadhyay, Daniel H. Huson, Daniel H. Huson, Sandip Paul, Sandip Paul   +13 more
doaj   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Asymmetric Reduction of Unactivated Alkenes

Chemistry – A European Journal, Volume 32, Issue 18, 14 May 2026.
Unactivated alkenes rank among the most inert functional groups in synthesis and their selective reduction remains challenging. This Review charts the evolution from classical metal‐catalyzed hydrogenation to radical hydrogen atom transfer (HAT) and emerging biocatalytic concepts, highlighting how complementary mechanistic strategies, including the ...
Nico D. Fessner, Sebastian Roth, Richard Niese, Michael Müller   +3 more
wiley   +1 more source

Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase [PDF]

, 2007
DNA is constantly damaged by a variety of exogenous and endogenous sources. To maintain the integrity of the genome, different DNA repair mechanisms have evolved, which deal with different kinds of DNA damage.
Rudolf, Jana
core   +2 more sources