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Cell Motility Dynamics in Glaucoma: Mechanisms, Pathogenic Roles, and Therapeutic Targeting [PDF]

Medicina
Cell motility—the dynamic process encompassing migration, adhesion modulation, cytoskeletal remodeling, and extracellular matrix (ECM) interactions—is fundamental to ocular homeostasis.
Dario Rusciano, Caterina Gagliano, Alessandro Avitabile, José Fernando Maya-Vetencourt   +3 more
doaj   +2 more sources

Bioimage Analysis and Cell Motility [PDF]

Patterns, 2021
Summary: Bioimage analysis (BIA) has historically helped study how and why cells move; biological experiments evolved in intimate feedback with the most classical image processing techniques because they contribute objectivity and reproducibility to an ...
Aleix Boquet-Pujadas, Jean-Christophe Olivo-Marin, Nancy Guillén   +2 more
doaj   +3 more sources

Profiling Dynamic Patterns of Single‐Cell Motility [PDF]

Advanced Science
Cell motility plays an essential role in many biological processes as cells move and interact within their local microenvironments. Current methods for quantifying cell motility typically involve tracking individual cells over time, but the results are ...
Debonil Maity, Nikita Sivakumar, Pratik Kamat, Nahuel Zamponi, Chanhong Min, Wenxuan Du, Hasini Jayatilaka, Adrian Johnston, Bartholomew Starich, Anshika Agrawal, Deanna Riley, Leandro Venturutti, Ari Melnick, Leandro Cerchietti, Jeremy Walston, Jude M. Phillip   +15 more
doaj   +2 more sources

Cell motility influences microfluidics capturing in scRNA-seq [PDF]

Open Res Eur
López-Escobar L, Nascimento AM, Figueiredo LM.   +2 more
europepmc   +4 more sources

Loss of Unconventional Myosin VI Affects cAMP/PKA Signaling in Hindlimb Skeletal Muscle in an Age-Dependent Manner

Frontiers in Physiology, 2022
Myosin VI (MVI) is a unique unconventional myosin ubiquitously expressed in metazoans. Its diverse cellular functions are mediated by interactions with a number of binding partners present in multi-protein complexes.
Lilya Lehka, Dominika Wojton, Małgorzata Topolewska, Vira Chumak, Łukasz Majewski, Maria Jolanta Rędowicz   +5 more
doaj   +1 more source

Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites

Open Biology, 2021
Expansion microscopy (ExM) has become a powerful super-resolution method in cell biology. It is a simple, yet robust approach, which does not require any instrumentation or reagents beyond those present in a standard microscopy facility.
Peter Gorilak, Martina Pružincová, Hana Vachova, Marie Olšinová, Marketa Schmidt Cernohorska, Vladimir Varga   +5 more
doaj   +1 more source

Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion

Cells, 2020
We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell’s waltzer ...
Lilya Lehka, Małgorzata Topolewska, Dominika Wojton, Olena Karatsai, Paloma Alvarez-Suarez, Paweł Pomorski, Maria Jolanta Rędowicz   +6 more
doaj   +1 more source

Targeted Next-Generation Sequencing Reveals Mutations in Non-coding Regions and Potential Regulatory Sequences of Calpain-3 Gene in Polish Limb–Girdle Muscular Dystrophy Patients

Frontiers in Neuroscience, 2021
Limb–girdle muscular dystrophy type R1 (LGMDR1) is caused by mutations in CAPN3 and is the most common type of recessive LGMD. Even with the use of whole-exome sequencing (WES), only one mutant allele of CAPN3 is found in a significant number of LGMDR ...
Anna Macias, Jakub Piotr Fichna, Malgorzata Topolewska, Maria J. Rȩdowicz, Anna M. Kaminska, Anna Kostera-Pruszczyk   +5 more
doaj   +1 more source

VASP-mediated actin dynamics activate and recruit a filopodia myosin

eLife, 2021
Filopodia are thin, actin-based structures that cells use to interact with their environments. Filopodia initiation requires a suite of conserved proteins but the mechanism remains poorly understood. The actin polymerase VASP and a MyTH-FERM (MF) myosin,
Ashley L Arthur, Amy Crawford, Anne Houdusse, Margaret A Titus   +3 more
doaj   +1 more source

Bacterial Motility in Biofilm Under Shear Flow

Chemical Engineering Transactions, 2022
A key role in bacteria surfaces contamination and biofilm development is played by cell motility and adhesion, that can be heavily dependent on flow conditions.
Daniele Marra, Federica Recupido, Giuseppe Toscano, Sergio Caserta   +3 more
doaj   +1 more source