Results 21 to 30 of about 537,274 (296)
Myosin 7 and its adaptors link cadherins to actin
Nature Communications, 2017 Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin ...
I-Mei Yu +8 more
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Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. [PDF]
PLoS ONE, 2010 Serine/threonine (Ser/Thr) protein phosphatase 2A (PP2A) has been implicated as a novel component of the mammalian target of rapamycin (mTOR) signaling pathway. Recently we have demonstrated that mTOR regulates cell motility in part through p70 S6 kinase
Lei Liu +8 more
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Parasite motility is critical for virulence of African trypanosomes. [PDF]
, 2018 African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions.
Geng, Quanjie +6 more
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One-dimensional cell motility patterns
Physical Review Research, 2020 During migration, cells exhibit a rich variety of seemingly random migration patterns, which makes unraveling the underlying mechanisms that control cell migration a difficult challenge. For efficient migration, cells require a mechanism for polarization,
Jonathan E. Ron +4 more
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Tracking Single Cells Motility on Different Substrates
Methods and Protocols, 2020 Motility is a key property of a cell, required for several physiological processes, including embryonic development, axon guidance, tissue regeneration, gastrulation, immune response, and cancer metastasis. Therefore, the ability to examine cell motility,
Pooja Sharma +3 more
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The tetraspanins CD9 and CD81 regulate CD9P1-induced effects on cell migration. [PDF]
PLoS ONE, 2010 CD9P-1 is a cell surface protein with immunoglobulin domains and an unknown function that specifically associates with tetraspanins CD9 and CD81. Overexpression of CD9P-1 in HEK-293 cells induces dramatic changes in cell spreading and migration on ...
Célia Chambrion, François Le Naour
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Virus-Induced Cell Motility [PDF]
Journal of Virology, 1998 ABSTRACT Many viruses induce profound changes in cell metabolism and function. Here we show that vaccinia virus induces two distinct forms of cell movement. Virus-induced cell migration was demonstrated by an in vitro wound healing assay in which infected cells migrated independently into the wound area while uninfected cells remained ...
C M, Sanderson, M, Way, G L, Smith
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Nature Communications, 2016 Establishment and maintenance of apico-basal polarity in epithelial organs needs to be tightly coupled with cell division. Here the authors show that the Rab35 GTPase tethers intracellular vesicles containing key apical determinants at the cleavage site,
Kerstin Klinkert +3 more
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Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. [PDF]
PLoS ONE, 2008 Actin-based cell motility and force generation are central to immune response, tissue development, and cancer metastasis, and understanding actin cytoskeleton regulation is a major goal of cell biologists.
Benjamin J Dubin-Thaler +9 more
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The Shape of Motile Cells [PDF]
Current Biology, 2009 Motile cells - fan-like keratocytes, hand-shaped nerve growth cones, polygonal fibroblasts, to name but a few - come in different shapes and sizes. We discuss the origins of this diversity as well as what shape tells us about the physics and biochemistry underlying cell movement.
Mogilner, Alex, Keren, Kinneret
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