Water Flux in Cell Motility : Expanding the Mechanisms of Membrane Protrusion [PDF]
, 2009 Transmembrane water fluxes through aquaporins (AQPs) are suggested to play, pivotal roles in cell polarization and directional cell motility. Local dilution by W water influences the dynamics of the subcortical actin polymerization and directs the ...
Magnusson, Karl-Eric, +2 more
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Oxidation of F-actin controls the terminal steps of cytokinesis
Nature Communications, 2017 Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated
Stéphane Frémont +11 more
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Regulation of the leading edge motility by PI (4,5)P2-dependent lipid microdomains [PDF]
, 2005 The lipid second messenger PI(4,5)P2 modulates actin dynamics, and its local accumulation at plasmalemmal microdomains (rafts) might mediate regulation of protrusive motility.
Golub, Tamara
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Fractional re-distribution among cell motility states during ageing
Communications Biology, 2021 Phillip and colleagues use dermal fibroblasts from a range of donors to quantify cell motility in ageing cells. They show that the age-dependent decrease in cell motility is not due to the reduced motility of all cells, but results from the fractional ...
Jude M. Phillip +10 more
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Optical trapping reveals propulsion forces, power generation and motility efficiency of the unicellular parasites Trypanosoma brucei brucei [PDF]
, 2014 Unicellular parasites have developed sophisticated swimming mechanisms to survive in a wide range of environments. Cell motility of African trypanosomes, parasites responsible for fatal illness in humans and animals, is crucial both in the insect vector ...
Engstler, M. +11 more
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An Exploratory Approach to Improved Mathematical Modeling of Cancer Cell Motility Utilizing In Vitro Biological Constants with an Emphasis on Cell Cycle [PDF]
, 2023 The goal of this project was to create a math model incorporating biological constants to build an in silico model that would more simulate cancer cell motility and growth.
Wolpert, Nicholas
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Myosin 7 and its adaptors link cadherins to actin
Nature Communications, 2017 Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin ...
I-Mei Yu +8 more
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A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity [PDF]
, 2010 Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L. +15 more
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Tracking Single Cells Motility on Different Substrates
Methods and Protocols, 2020 Motility is a key property of a cell, required for several physiological processes, including embryonic development, axon guidance, tissue regeneration, gastrulation, immune response, and cancer metastasis. Therefore, the ability to examine cell motility,
Pooja Sharma +3 more
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Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. [PDF]
PLoS ONE, 2010 Serine/threonine (Ser/Thr) protein phosphatase 2A (PP2A) has been implicated as a novel component of the mammalian target of rapamycin (mTOR) signaling pathway. Recently we have demonstrated that mTOR regulates cell motility in part through p70 S6 kinase
Lei Liu +8 more
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