Results 21 to 30 of about 551,941 (324)
FAK-Dependent Cell Motility and Cell Elongation
Cells, 2020 Fibroblastic cells show specific substrate selectivity for typical cell−substrate adhesion. However, focal adhesion kinase (FAK) contributes to controlling the regulation of orientation and polarity.
Kazuo Katoh
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Oxidation of F-actin controls the terminal steps of cytokinesis
Nature Communications, 2017 Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated
Stéphane Frémont +11 more
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Parasite motility is critical for virulence of African trypanosomes. [PDF]
, 2018 African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions.
Geng, Quanjie +6 more
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Fractional re-distribution among cell motility states during ageing
Communications Biology, 2021 Phillip and colleagues use dermal fibroblasts from a range of donors to quantify cell motility in ageing cells. They show that the age-dependent decrease in cell motility is not due to the reduced motility of all cells, but results from the fractional ...
Jude M. Phillip +10 more
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Stripe formation in bacterial systems with density-suppressed motility [PDF]
, 2012 Engineered bacteria in which motility is reduced by local cell density generate periodic stripes of high and low density when spotted on agar plates. We study theoretically the origin and mechanism of this process in a kinetic model that includes growth ...
Chenli Liu +7 more
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Myosin 7 and its adaptors link cadherins to actin
Nature Communications, 2017 Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin ...
I-Mei Yu +8 more
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One-dimensional cell motility patterns
Physical Review Research, 2020 During migration, cells exhibit a rich variety of seemingly random migration patterns, which makes unraveling the underlying mechanisms that control cell migration a difficult challenge. For efficient migration, cells require a mechanism for polarization,
Jonathan E. Ron +4 more
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Tracking Single Cells Motility on Different Substrates
Methods and Protocols, 2020 Motility is a key property of a cell, required for several physiological processes, including embryonic development, axon guidance, tissue regeneration, gastrulation, immune response, and cancer metastasis. Therefore, the ability to examine cell motility,
Pooja Sharma +3 more
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Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. [PDF]
PLoS ONE, 2010 Serine/threonine (Ser/Thr) protein phosphatase 2A (PP2A) has been implicated as a novel component of the mammalian target of rapamycin (mTOR) signaling pathway. Recently we have demonstrated that mTOR regulates cell motility in part through p70 S6 kinase
Lei Liu +8 more
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The tetraspanins CD9 and CD81 regulate CD9P1-induced effects on cell migration. [PDF]
PLoS ONE, 2010 CD9P-1 is a cell surface protein with immunoglobulin domains and an unknown function that specifically associates with tetraspanins CD9 and CD81. Overexpression of CD9P-1 in HEK-293 cells induces dramatic changes in cell spreading and migration on ...
Célia Chambrion, François Le Naour
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