Results 241 to 250 of about 77,925 (335)

Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors

ChemistryOpen, Volume 14, Issue 5, May 2025.
Benzo[cd]indol‐2(1H)‐one 1 inhibits the Hedgehog signaling pathway downstream of Suppressor of Fused, lowering cellular and ciliary GLI2 levels, and preventing GLI1 expression. A PROTAC‐based competition assay validated the cellular engagement of BET bromodomains, adding compound 1 to the growing set of epigenetic modulators of the Hedgehog signaling ...
Ioannis A. Tsakoumagkos, Quentin T. L. Pasquer, Christian‐Louis Guillod, Charlotte Rossion, Meropi Bagka, Sonya Torche, Tomoyo Sakata‐Kato, James K. Chen, Sascha Hoogendoorn   +8 more
wiley   +1 more source

Long-Chain Cyclic Arylguanidines as Multifunctional Serotonin Receptor Ligands with Antiproliferative Activity. [PDF]

ACS Omega
Zaręba P, Drabczyk AK, Wnorowski A, Maj M, Rurka P, Malarz K, Latacz G, Nędza K, Ciura K, Greber KE, Boguszewska-Czubara A, Śliwa P, Kuliś J.   +12 more
europepmc   +1 more source

Erratum to : Syntheses of Sulfonamides. II

, 1950

openalex   +2 more sources

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings

Pediatric Discovery, EarlyView.
Abstract Spina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele—the most severe form of spina bifida often associated with a markedly diminished quality of life—accounts for a significant portion of cases.
Ethan S. Wong, Daniel A. Hu, Lily Zhang, Rachel Qi, Cindy Xu, Ou Mei, Guowei Shen, Wulin You, Changqi Luo, Tong‐Chuan He, Russell R. Reid, Lewis S. Shi, Michael J. Lee, Yi Zhu   +13 more
wiley   +1 more source

Synthesis, biological investigation, and in silico studies of 2-aminothiazole sulfonamide derivatives as potential antioxidants. [PDF]

EXCLI J
Worachartcheewan A, Pingaew R, Prachayasittikul V, Apiraksattayakul S, Prachayasittikul S, Ruchirawat S, Prachayasittikul V.   +6 more
europepmc   +1 more source

THE EFFECT OF SULFONAMIDE IN THE DIET OF PREGNANT RATS ON ERYTHROPOIESIS IN THE FETUSES

, 1948
Martin B. Williamson, Muriel. Appel
openalex   +1 more source

Eco‐friendly rubber compounds: Utilizing animal lard as a plasticizer oil

Polymer Engineering &Science, EarlyView.
Comparing eco‐friendly waste animal lard with vegetable and petroleum‐based plasticizers for rubber compounding. Abstract Melt‐mixing technique was used to compound eco‐friendly plasticizer, pork fat oil (PF) and natural rubber (NR)‐carbon black (CB) and studied systematically.
Bismark Mensah, Winston Amobeng, Vitus Apalangya, Emmanuel Essien, Kan‐Dapah Kwabena, Elijah Nyakudya, Tsatsu Nukunya   +6 more
wiley   +1 more source

Iridium-catalyzed reductive sulfonamidation of alkoxy aryl alkynes. [PDF]

RSC Adv
Liang Y, Liu C, Wei P, Ouyang L, Li Y.
europepmc   +1 more source

Fluoroquinolones and the risk of aortic aneurysm or dissection: A population‐based propensity score‐matched German cohort study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Objective To investigate the risk of aortic aneurysm or dissection associated with fluoroquinolone (FQ) prescription compared to macrolides in German routine health care data in order to replicate the recent study (Pharmacotherapy 2023;43:883) extending the results by contributing evidence for six additional broad‐spectrum antibiotic classes ...
Julia Wicherski, Jonas Peltner, Cornelia Becker, Katrin Schüssel, Gabriela Brückner, Andreas Schlotmann, Helmut Schröder, Winfried V. Kern, Britta Haenisch   +8 more
wiley   +1 more source