Results 261 to 270 of about 115,474 (373)

Vitamin B2 Synthesis by sulfonamide-resistant strain of Aerobacter aerogenes

, 1950
Sadayoshi Hatta, K Koshinuma, Hareo MIYAMOTO   +2 more
openalex   +2 more sources

International Validation of the SULF-FAST Risk-Stratification Tool for Sulfonamide Antibiotic Allergy.

JAMA Netw Open
Stehlin F, Vogrin S, Mitri E, Isabwe GAC, Trubiano JA, Copaescu AM.   +5 more
europepmc   +1 more source

Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study. [PDF]

Pharmacol Res Perspect
Lolak N, Akocak S, Topal M, Koçyiğit ÜM, Işık M, Türkeş C, Topal F, Durgun M, Beydemir Ş.   +8 more
europepmc   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer's Disease. [PDF]

J Med Chem
Košak U, Strašek Benedik N, Knez D, Žakelj S, Trontelj J, Pišlar A, Horvat S, Bolje A, Žnidaršič N, Grgurevič N, Švara T, Kljun J, Skrzypczak-Wiercioch A, Lv B, Xiong Y, Wang Q, Bian R, Shao J, Dias J, Nachon F, Brazzolotto X, Stojan J, Sun H, Sałat K, Gobec S.   +24 more
europepmc   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Kinetic Resolution of Racemic Amines via Palladium/Chiral Phosphoric Acid-Catalyzed Intramolecular Allylation: Stereodivergent Access to Chiral 1,3-Disubstituted Isoindolines. [PDF]

J Org Chem
Wu BS, Lin YM, Tsai CC.
europepmc   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Erratum to : Syntheses of Sulfonamides. II

, 1950

openalex   +2 more sources

Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development. [PDF]

Sci Rep
Bilal MS, Ejaz SA, Naseem S, Channar PA, Saeed A, Zargar S, Ujan R, Sahito R, Abbas Q, Wani TA.   +9 more
europepmc   +1 more source