Results 131 to 140 of about 46,498 (299)
Chemistry – A European Journal, EarlyView.The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma +13 more
wiley +1 more source
Oxidative Generation and Reactivity of the Cyclopropyl Radical From a Martin Silicate
Chemistry – A European Journal, EarlyView.A photoredox strategy employing Martin silicates enables the oxidative generation and controlled capture of cyclopropyl radicals, including the naked one, long considered challenging intermediates. The method affords functionalized cyclopropanes through both Giese‐type additions and dual nickel/photoredox C(sp3)−C(sp2) cross‐couplings.
Amal Lakhal +3 more
wiley +1 more source
Synthesis of new sulfonamides containing benzthiazole block
, 2017 Práce je věnována přípravě nových chirálních sulfonamidů obsahujících benzthiazolový blok. Byla provedena literární rešerše s cílem nalézt vhodné metody přípravy sulfonamidů obsahující benzthiazolový blok a jejich biologické aktivity.
Odehnalová, Hana
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Chinese Journal of Chemistry, EarlyView.Under copper(I) catalysis, pentafluoroethylated alkenes can undergo smooth defluorosilylation to generate novel polyfluorinated products. The reaction exhibits high levels of diastereoselectivities for obtaining multisubstituted allylsilanes with control of the double bond geometry.
Yuwei Zong, Yihan Tang, Gavin Chit Tsui
wiley +1 more source
, 2014 Citation: 'sulfonamides' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.S06114 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Drug Testing and Analysis, EarlyView.This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug +6 more
wiley +1 more source
Retention mechanism of sulfonamides in micellar reversed phase liquid chromatography
, 2011 A mechanism of retention of sulfonamides in the micellar liquid chromatography, based on similar models verified for other compounds, was proposed. The magnitudes of hydrophobic and electrostatic interactions of sulfonamides were estimated for different ...
Szymański, A.
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Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates
A plethora of drug molecules and agrochemicals contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described,
Loïc R. E. Pantaine (11565981) +5 more
core +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.This work developed a low‐temperature sludge hydrothermal coupled with gel crosslinking strategy which could upgrade the waste liquid generated from sewage sludge hydrothermal treatment into the hydrothermal‐liquid‐gel. The inventive hydrothermal‐liquid‐gel exhibited the enhanced pollutant removal capability, high synthetic stability, and superior ...
Zifan Liu +12 more
wiley +1 more source
Treatment of Mastitis Using Agents Other Than Antibiotics and Sulfonamides
, 1956 Rothenberg points out the threat arising from bacterial strains becoming resistant to antibiotics and sulfonamides, and those resistant to such therapy per se, both of which are becoming more prominent in mastitis, with extensive and indiscriminate use ...
Douglas, Earle
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