Results 51 to 60 of about 77,413 (299)

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Fast and Selective Post-polymerization Modification of Conjugated Polymers Using Dimethyldioxirane

Frontiers in Chemistry, 2019
Modification of functional groups attached to conjugated polymer backbones can drastically alter the material properties. Oxidation of electron-donating thioalkyl substituents to electron-withdrawing sulfoxides or sulfones is a particularly effective ...
Emmanuel Reichsöllner, Adam Creamer, Shengyu Cong, Abby Casey, Simon Eder, Martin Heeney, Florian Glöcklhofer, Florian Glöcklhofer   +7 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

The formation of nodular structures in the top layer of ultrafiltration membranes [PDF]

, 1994
The formation of nodular structures in the top layer of ultrafiltration membranes is considered. A critical review of mechanisms described in the literature is given.
Smolders, C.A., Smolders, C.A., van den Boomgaard, Anthonie, Wienk, I.M., Wienk, I.M.   +4 more
core   +7 more sources

Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

Chemistry
Tyrosyl-DNA phosphodiesterases 1 and 2 (TDP1 and TDP2) are important DNA repair enzymes that remove various adducts from the 3′- and 5′-ends of DNA, respectively.
Aleksandr S. Filimonov, Marina A. Mikhailova, Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Tatyana E. Kornienko, Konstantin A. Naumenko, Rashid O. Anarbaev, Andrey A. Nefedov, Chigozie Achara, Anthony D. M. Curtis, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik, Jóhannes Reynisson   +14 more
doaj   +1 more source

1-Nitro-3-[(phenylsulfonyl)methyl]benzene

Molbank, 2006
n ...
Daniel G. Grohmann, Bruce A. Hathaway
doaj   +1 more source

Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space [PDF]

, 2015
Novel oxetane motifs incorporating diverse functional groups on the ring are readily accessed by an O–H insertion/cyclisation strategy.
Bull, JA, Croft, RA, Davis, OA
core   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

erythro-{1-Bromo-1-[(1-phenylethyl)sulfonyl]ethyl}benzene

IUCrData
The title compound, C16H17BrO2S, crystallizes as the erythro (RR/SS) isomer of a pair of sulfones that were diastereomeric due to chirality of the α-carbon atoms on the sulfone sulfur atom.
Peter W. R. Corfield
doaj   +1 more source

Studies on the Synthesis, Stability and Conformation of 2-Sulfonyl-Oxetane Fragments [PDF]

, 2015
A library of 2-sulfonyl oxetane fragments has been synthesised and elaborated into lead-like compounds. The oxetane derivatives were stable to acidic and basic conditions and have 3-preferred conformations.
Bull, JA, Hollingsworth, IA, Morgan, KF
core   +1 more source