Results 41 to 50 of about 27,055 (203)

Time to Treatment Intensification in Patients Receiving DPP4 Inhibitors Versus Sulfonylureas as the First Add-On to Metformin Monotherapy: A Retrospective Cohort Study

Frontiers in Pharmacology, 2022
Background: To verify whether, in patients on metformin (MET) monotherapy for type 2 diabetes (T2D), the add-on of a dipeptidyl peptidase inhibitor (DPP4i) compared to a sulfonylurea (SU) can delay the time to the subsequent treatment intensification (TI)
Giuseppe Roberto, Anna Girardi, Francesco Barone-Adesi, Alessandro Pecere, Valentina Ientile, Claudia Bartolini, Roberto Da Cas, Stefania Spila-Alegiani, Carmen Ferrajolo, Paolo Francesconi, Gianluca Trifirò, Elisabetta Poluzzi, Fabio Baccetti, Rosa Gini   +13 more
doaj   +1 more source

Cytochrome P450 2C9*2 and *3 polymorphisms and the dose and effect of sulfonylurea in type II diabetes mellitus

, 2008
Sulfonylurea hypoglycemics are mainly metabolized by the cytochrome P450 2C9 ( CYP2C9) enzyme. The CYP2C9*2 and *3 polymorphisms encode proteins with less enzymatic activity and are correlated with elevated serum levels of sulfonylurea, as demonstrated ...
Stricker, Bruno, Visser, Loes, Becker, Matthijs, Hofman, Bert, Trienekens, PH, van Schaik, Ron   +5 more
core   +1 more source

Rural Residence is Associated with a Delayed Trend Away From Sulfonylurea Use for Treatment Intensification of Type 2 Diabetes

, 2023
   Objective: To examine the intersection between location of residence along the rural-urban continuum (metropolitan/urban/rural) and sulfonylurea dispensation records for the management of type 2 diabetes.
Lauren C. Bresee (719773), Dean T. Eurich (9018458), Danielle K Nagy (14281551), Scott H. Simpson (2602048)   +3 more
core   +1 more source

Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure

Nutrition & Diabetes
Background Sulfonylureas have long been utilized in the management of type-2 diabetes mellitus (T2DM) due to their insulin-secretagogue properties. However, their clinical efficacy is hindered by the risk of severe hypoglycemia and secondary sulfonylurea
Jung Gyu Park, Minseok Kim, Sungje Yoo, Sun Wook Hwang, Jongsoo Mok, Joonghoon Park, Keon Wook Kang   +6 more
doaj   +1 more source

Potencial de uso dos herbicidas chlorimuron-ethyl, imazethapyr e cloransulam-methyl na cultura do feijão Potential use of chlorimuron-ethyl, imazethapyr and cloransulam-methyl in common bean crop

Planta Daninha, 2009
O objetivo deste trabalho foi avaliar a seletividade dos herbicidas chlorimuron-ethyl, imazethapyr e cloransulam-methyl, aplicados em associação com o herbicida fomesafen, a dez cultivares de feijão.
S.O. Procopio, A.J.B.P. Braz, A.L.L. Barroso, A. Cargnelutti Filho, K.L. Cruvinel, M. Betta, G.B.P. Braz, J.J.S. Fraga Filho, L.D. Cunha Júnior   +8 more
doaj   +1 more source

In Vitro Evaluation of Drug–Drug Interaction Between Gliclazide and Antacids at the Absorption Level

Pharmaceuticals
Background: The antidiabetic drug gliclazide is often taken with antacids due to its gastrointestinal side effects. However, patients rarely report antacid use, making drug–drug interactions a potential cause of therapy failure.
Slavica Lazarević, Srđan Kosijer, Maja Đanić, Dragana Zaklan, Bojan Stanimirov, Momir Mikov, Nebojša Pavlović   +6 more
doaj   +1 more source

Deintensification of Treatment with Sulfonylurea and Insulin after Severe Hypoglycemia among Older Adults with Diabetes [PDF]

, 2021
Importance: Practice guidelines recommend deintensification of hypoglycemic agents among older adults with diabetes who are at high risk of hypoglycemia, yet real-world treatment deintensification practices are not well characterized.
Bradley, M.C., Alexopoulos, A.-S., Kahkoska, A.R., Thorpe, C., Buse, J., Niznik, J., Stürmer, T., Pate, V.   +7 more
core   +1 more source

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

eLife, 2017
KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas.
Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng   +7 more
doaj   +1 more source

Reasoned opinion on the review of the existing maximum residue levels (MRLs) for nicosulfuron according to Article 12 of Regulation (EC) No 396/2005 [PDF]

EFSA Journal, 2012
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance nicosulfuron.
European Food Safety Authority
doaj   +1 more source

Resistência de plantas daninhas aos herbicidas inibidores da ALS na cultura da soja (Glycine max) Weed resistance to ALS - inhibiting herbicides in soybean (Glycine max) crop

Planta Daninha, 2000
As plantas daninhas Bidens pilosa/Bidens subalternans (picão-preto) e Amaranthus quitensis (caruru) são controladas na cultura da soja por diversos herbicidas, sendo os inibidores da acetolactato sintase (ALS) os mais utilizados pelos sojicultores. O uso
P.A. Monqueiro, P.J. Christoffoleti, C.T.S. Dias   +2 more
doaj   +1 more source