Results 241 to 250 of about 26,552 (294)

Glycemic Control and Utilization Risk With the Conversion of Glimepiride to Glipizide in Adults 64 Years and Older at an Integrated Health Care System. [PDF]

open access: yesJ Am Geriatr Soc
Lee EA   +10 more
europepmc   +1 more source

Cardiac Effects of Sulfonylurea-Related Hypoglycemia

open access: yesDiabetes Care, 2017
OBJECTIVE To determine the effect of sulfonylurea-related hypoglycemia on cardiac repolarization and ectopy in the setting of well-controlled type 2 diabetes. RESEARCH
Stephen Twigg   +2 more
exaly   +2 more sources

Sulfonylureas in NIDDM

Diabetes Care, 1992
Sulfonylureas have represented the backbone of oral therapy in non-insulin-dependent diabetes mellitus for > 30 yr. Despite this, our knowledge about the mode of actions of these agents is limited, and the use of them is far from rational. Sulfonylureas lower blood glucose concentrations primarily by stimulating insulin secretion.
openaire   +2 more sources

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor I. Binding characteristics [PDF]

open access: yesBiochimica Et Biophysica Acta - Biomembranes, 1994
Glimepiride is a novel sulfonylurea drug for treatment of non-insulin-dependent diabetes mellitus with higher blood sugar lowering efficacy in diabetic patients than glibenclamide raising the question whether this characteristics is in line with ...
Gunter Müller, Werner Kramer
exaly   +2 more sources

Potential Hypoglycemic Sulfonylureas

Journal of Pharmaceutical Sciences, 1964
A series of N ′-alkyl- N - p -phenylbenzenesulfonylureas and N , N ′-bis ( N -alkylcarbamyl) 4,4′-biphenyldisulfonamides has been prepared for pharmacological studies of their hypoglycemic activities.
K A, NIEFORTH, G L, JENKINS, A M, KNEVEL
openaire   +2 more sources

[Sulfonylureas].

Acta medica portuguesa, 1990
Oral antidiabetics are an important aspect of treatment in many diabetics and in the last few years with new developments in the knowledge of type II diabetes physiopathology, there has been a lot of interest in their actions mechanisms. Oral therapy is nevertheless a mere complement which needs to be fitted into a wider group of measures: diabetics ...
openaire   +3 more sources

Hepatic effect of sulfonylureas

Metabolism, 1970
Abstract The sulfonylureas, tolbutamide, tolazamide and acetohexamide significantly diminish uptake of insulin by the isolated perfused rat liver, whereas the nonhypoglycemic metabolite of tolbutamide, carboxytolbutamide, has no such effect. These results suggest that the sustained action of the sulfonylureas may in part be due to reduced hepatic ...
A, Marshall, R L, Gingerich, P H, Wright
openaire   +2 more sources

Sulfonylureas

Sulfonylureas have been a mainstay in the pharmacologic treatment of T2D for over 60 years. The first-generation sulfonylureas (e.g., chlorpropamide, tolbutamide, and tolazamide) are no longer available in the United States. With the availability of many noninsulin classes of medications for T2D, sulfonylurea usage is on the decline, yet their use ...
Elmo M. Beyer   +3 more
openaire   +2 more sources

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