Results 61 to 70 of about 24,524 (277)

A Trp574–Leu substitution confers resistance to three classes of acetolactate synthase inhibitors in Australian brome grass (Bromus diandrus)

Pest Management Science, EarlyView.
Target‐site based imidazolinone resistance in brome grass was found to be conferred by a mutation at position 574 in the ALS gene and to severely impact the efficacy of the herbicide Intervix®, a co‐formulation of imazamox and imazapyr. Abstract BACKGROUND Brome grass (Bromus diandrus) is a prevalent weed in southern Australian cropping regions which ...
Roberto Busi, Danica Goggin, Nick Eyres, Fabian Runge, Aimone Porri, Ken Flower   +5 more
wiley   +1 more source

Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury

, 2017
OBJECTIVES: Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies.
Chang, Chung-Chou H, Wallisch, Jessica S, Ruchira M. Jha, Ava M. Puccio, Patrick M. Kochanek, Keri L. Janesko-Feldman, Bradley J. Molyneaux, Sherry Hsiang-Yi Chou, Chung-Chou H. Chang, David O. Okonkwo, Jha, Ruchira M, Jessica S. Wallisch, Shutter, Lori A, Lori A. Shutter, Janesko-Feldman, Keri L, Chou, Sherry Hsiang-Yi, Molyneaux, Bradley J, Okonkwo, David O, Samuel M. Poloyac, Zusman, Benjamin E, Benjamin E. Zusman, Puccio, Ava M, Kochanek, Patrick M, Poloyac, Samuel M   +23 more
core   +1 more source

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

Protein & Cell, 2018
ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level.
Jing-Xiang Wu, Dian Ding, Mengmeng Wang, Yunlu Kang, Xin Zeng, Lei Chen   +5 more
doaj   +1 more source

Genotype and Phenotype Heterogeneity in Neonatal Diabetes: A Single Centre Experience in Turkey

JCRPE, 2021
Objective:Neonatal diabetes mellitus (NDM) may be transient or permanent, and the majority is caused by genetic mutations. Early diagnosis is essential to select the patients who will respond to oral treatment.
Yasemin Denkboy Öngen, Erdal Eren, Özgecan Demirbaş, Elif Sobu, Sian Ellard, Elisa De Franco, Ömer Tarım   +6 more
doaj   +1 more source

Pro‐197 mutations confer resistance to thiencarbazone but not to foramsulfuron in ALS‐resistant Poa annua populations

Pest Management Science, EarlyView.
Foramsulfuron remains effective on Pro‐197 Poa annua, but co‐formulation with thiencarbazone reduces efficacy due to limited activity and antagonism. Therefore, foramsulfuron + thiencarbazone should be used in fields without ALS‐resistant weeds to ensure effective in‐crop control.
Vijaya Bhaskar Alwarnaidu Vijayarajan, Iniya Vijayakumar, Rafa Ruiz‐Partida, Fabian Runge, Joel Torra, Jorge Lozano‐Juste, Patrick Dermot Forristal   +6 more
wiley   +1 more source

Peri‐operative management of diabetes mellitus: a multidisciplinary consensus statement from the Association of Anaesthetists and the Joint British Diabetes Societies for Inpatient Care group

Anaesthesia, EarlyView.
Summary Introduction Surgery in patients with diabetes mellitus is associated with increased morbidity and mortality compared with those who do not have diabetes mellitus. This is likely multifactorial and could be attributed to organisational issues; dysglycaemia; hospital‐acquired diabetic ketoacidosis; errors with insulin prescribing and ...
Nicholas A. Levy, Kariem El‐Boghdadly, Dileep N. Lobo, Daniel J. Stubbs, Parizad Avari, Donal Buggy, Claire Frank, Kim Howson, Jinty Moffett, Emma Morris, Omar G. Mustafa, Glynn Nash, Pádraig Ó Scanaill, Sarah Procter, Gerry Rayman, Kim Russon, Caroline Thomas, Sarah Tinsley, Allan Xu, Ketan Dhatariya   +19 more
wiley   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Standen, N.B., Yellon, D.M., Lawrence, C.L., Maddock, H.L., Mocanu, M.M.   +5 more
core  

Cardiac Effects of Sulfonylurea-Related Hypoglycemia

, 2017
OBJECTIVE To determine the effect of sulfonylurea-related hypoglycemia on cardiac repolarization and ectopy in the setting of well-controlled type 2 diabetes. RESEARCH
Lynda Molyneaux, Jencia Wong, Timothy L. Middleton, Belinda A. Brooks, Dennis K. Yue, Stephen M. Twigg, Ted Wu   +6 more
core   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Estimating the effect of sulfonylurea on HbA1c in diabetes: a systematic review and meta-analysis

, 2013
AIMS/HYPOTHESIS: Sulfonylureas are widely prescribed glucose-lowering medications for diabetes, but the extent to which they improve glycaemia is poorly documented.
R. J. Stevens, Farmer, AJ, Stevens, Richard, Hirst, JA, Hirst, Jennifer, Dyar, A, A. J. Farmer, Lung, TWC, A. Dyar, Stevens, RJ, J. A. Hirst, Farmer, Andrew, T. W. C. Lung, Lung, TW   +13 more
core   +2 more sources