Results 21 to 30 of about 26,603 (276)

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen, Wied, Susanne, Pünter, Jürgen, Unkelbach, Angelika, Crecelius, Anna, Müller, Günter   +5 more
core   +1 more source

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes. [PDF]

Clin Pharmacol Ther
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Breeyear JH, House JS, Kvale M, Nam S, Akhtari FS, Shah HS, Hedderson MM, Giacomini KM, Mychaleckyj JC, Doria A, Wagner MJ, Li JH, Yee SW, Buse JB, Woychik RP, Rotroff DM, Motsinger-Reif AA.   +16 more
europepmc   +2 more sources

Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study [PDF]

Endocrinology and Metabolism
Background Inconsistent results have been reported regarding the association between the use of antidiabetic drugs and the clinical outcomes of coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of antidiabetic drugs on COVID-
Han Na Jang, Sun Joon Moon, Jin Hyung Jung, Kyung-Do Han, Eun-Jung Rhee, Won-Young Lee   +5 more
doaj   +1 more source

MODY3 in the child with type 2 diabetes mellitus phenotype: case report

Сахарный диабет, 2013
MODY is a heterogeneous group of diseases that stem from certain genetic mutations and are characterized by beta-cell dysfunction, early clinical onset (before the age of 25) and autosomal dominant inheritance.
Tamara Leonidovna Kuraeva, Elena Alexandrovich Sechko, Irina Alexandrovna Eremina, O N Ivanova, Sergey Alexandrovich Prokof’ev   +4 more
doaj   +1 more source

Comparison of diabetes phenotype in children and their mothers with permanent neonatal diabetes mellitus carrying the same KCNJ11 variants

Endocrine Regulations, 2020
Objective. Mutations of the KCNJ11 gene are the most common cause of the permanent neonatal diabetes mellitus (PNDM). Majority of people with KNCJ11-PNDM have a de-novo mutation.
Stanik Juraj, Barak Lubomir, Dankovcikova Adriana, Valkovicova Terezia, Skopkova Martina, Gasperikova Daniela   +5 more
doaj   +1 more source

Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in Egyptian patients with type 2 diabetes

Therapeutic Advances in Endocrinology and Metabolism, 2011
Objective: This study investigated the possibility that genetic factors, such as polymorphism of K inward rectifier subunit (Kir6.2), E23K, and Arg 972 polymorphism of insulin receptor substrate-1 (IRS-1), may predispose patients to sulfonylurea failure.
Alaa E. El-sisi, Sahar K. Hegazy, Shereen S. Metwally, Alaa M. Wafa, Naglaa A. Dawood   +4 more
doaj   +1 more source

Changing Patterns of Antihyperglycaemic Treatment among Patients with Type 2 Diabetes in Hungary between 2015 and 2020—Nationwide Data from a Register-Based Analysis

Medicina, 2022
Background and objectives: In the last couple of years, pharmacological management of patients with type 2 diabetes mellitus (T2DM) have been markedly renewed. The aim of this study was to analyse the changes in prescribing patterns of antidiabetic drugs
György Jermendy, Zoltán Kiss, György Rokszin, Zsolt Abonyi-Tóth, Csaba Lengyel, Péter Kempler, István Wittmann   +6 more
doaj   +1 more source

Efeitos da adubação nitrogenada em cobertura sobre a seletividade de herbicidas à cultura do milho Effects of cover nitrogen fertilization on herbicide selectivity in corn

Planta Daninha, 2006
O objetivo deste trabalho foi avaliar os efeitos da adubação nitrogenada de cobertura sobre a seletividade dos herbicidas aplicados em pós-emergência na cultura do milho (Zea mays). Para isso, foram conduzidos dois experimentos.
M. Nicolai, R.F. López Ovejero, S.J.P. Carvalho, M.S. Moreira, P.J. Christoffoleti   +4 more
doaj   +1 more source

Assessment of methyl 2-({[(4,6-dimethoxypyrimidin-2-yl)carbamoyl] sulfamoyl}methyl)benzoate through biotic and abiotic degradation modes

Open Chemistry, 2020
Detoxification and management of environmental contaminants is an exigent issue of current times. Sulfonylurea herbicide, Bensulfuron-methyl was investigated for its degradation demeanour in soils, through biotic and abiotic modes (biodegradation and ...
Gul Mahwash Mahar, Ahmad Khuram Shahzad
doaj   +1 more source

Risk of Severe Hypoglycemia Associated With Concomitant Use of Sulfonylureas and Amiodarone. [PDF]

Diabetes Obes Metab
ABSTRACT Aims To evaluate whether initiation of amiodarone while receiving sulfonylurea is associated with an increased risk of severe hypoglycemia compared with the initiation of other antiarrhythmic agents (flecainide, sotalol, or propafenone) while receiving sulfonylurea. Materials and Methods We conducted a population‐based cohort study using South
Bea S, Lee H, Cho YM, Choi YJ, Shin JY, Bykov K.   +5 more
europepmc   +2 more sources