Results 91 to 100 of about 5,580 (266)

Changes in the Activity and Selectivity of Herbicides by Selective Fluorine Substitution, Taking Bentranil and Classic® Analogues as Examples

CHIMIA, 2004
The introduction of fluorine atoms into 2-phenyl-4H-3,1-benzoxazin-4-one (bentranil) led to sweeping changes in its herbicidal properties in some cases, and 5-fluoro-2-phenyl-4H-3,1-benzoxazin-4-one ('fluorobentranil') was found to be the most ...
Gerhard Hamprecht, Bruno Würzer, Matthias Witschel   +2 more
doaj   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Influência de chalconas análogas, xantonas e monossacarídeos na glicemia em modelo experimental animal [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.O objetivo deste trabalho foi estudar o efeito de chalconas análogas (derivadas do 3,4-metilenodióxi-benzaldeído, 2 ...
Alberton, Elga Heloisa
core  

Metabolomic insights into the intricate gut microbial–host interaction in the development of obesity and type 2 diabetes

Frontiers in Microbiology, 2015
Gut microbiota has recently been proposed as a crucial environmental factor in the development of metabolic diseases such as obesity and type 2 diabetes, mainly due to its contribution in the modulation of several processes including host energy ...
Magali ePalau-Rodriguez, Sara eTulipani, Sara eTulipani, MARIA ISABEL MI QUEIPO ORTUÑO, Mireia eUrpi-Sarda, Francisco J Tinahones, Cristina eAndres-Lacueva   +6 more
doaj   +1 more source

Cardiovascular Outcomes in a SELECT‐Like Obesity Cohort: Real‐World Insights From the Swedish AROS Database

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background In the SELECT trial, semaglutide reduced major adverse cardiovascular outcomes (MACE) in individuals with overweight or obesity and established cardiovascular disease (CVD) but without diabetes. However, real‐world cardiovascular event rates in comparable populations remain uncharacterised.
Viveca Ritsinger, Josefine Fagerström, Håkan Nero, Thomas Cars, Maria K. Svensson, Anna Norhammar   +5 more
wiley   +1 more source

Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin

, 2014
Three series of novel sulfonylurea podophyllotoxin derivatives were designed, synthesized, and evaluated for in vitro cytotoxicity against four tumor cell lines (A-549, DU-145, KB and KBvin). Compounds 14c (IC50: 1.41–1.76 μM) and 14e (IC50: 1.72–2.01 μM)
Wang, Mei Juan, Liu, Ying Qian, Zhang, Zhi Jun, Morris-Natschke, Susan L., Lee, Kuo Hsiung, Wang, Li Ting, Tian, Jing, Yang, Liu, Nan, Xiang   +8 more
core   +2 more sources

The Effects of Combined Antihypertensive and Antidiabetic Therapies on Cardiovascular Outcomes: A Systematic Review and Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Hypertension and diabetes frequently coexist, yet the net clinical impact of intentionally combining antihypertensive (AHTN) and antidiabetic (ADA) therapies on cardiovascular (CV) outcomes is uncertain. Here we quantified the effects of AHTN and ADA co‐therapy on CV and blood pressure (BP)/heart rate (HR) outcomes.
Wan Chin Hsieh, Brandon Michael Henry, István Édes   +2 more
wiley   +1 more source

Examination of the translocation of sulfonylurea herbicides in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging

, 2010
Pesticides are widely used in agriculture to control weeds, pests and diseases. Successful control is dependent on the compound reaching the target site within the organism after spray or soil application.
David M. G. Anderson, Malcolm R. Clench, Susan Crosland, Carolan, V. A., Clench, M. R., Sharples, K. R., Vikki A. Carolan, Anderson, D. M. G., Kate R. Sharples, Crosland, S.   +9 more
core   +1 more source

Empagliflozin Versus Dapagliflozin and Urogenital Adverse Events in Type 2 Diabetes: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Urogenital adverse events are common with sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) and may influence treatment decisions. Variations in SGLT2i selectivity, potency and effects on renal glucose excretion could lead to differences in safety profiles. We compared the risks of urinary tract infection (UTI), genital tract infection (
Christine Ljungberg, Kasper Bonnesen, Morten Schmidt, Christina Vandenbroucke‐Grauls, Michael Dalager‐Pedersen, Henrik Toft Sørensen, Mette Nørgaard, Reimar Wernich Thomsen   +7 more
wiley   +1 more source

Theoretical study of structural and electronic trends of sulfonylurea herbicides family [PDF]

The sulfonylurea herbicide family has beenextensively studied using computational techniques. The moststable conformer structures of the 34 molecules analyzed ingaseous, aqueous, and octanol phases have been determined.
Pla, Paula, Sandín España, Pilar, Valentín, Mónica, Lamsabhi, Al Mokhtar, Lamsabhi, A. M., Alcamí, M., Valentín Rodríguez, Mónica Angels, Pulgar Rubio, Antonio, Pla Terrada, Paula, Alcamí Pertejo, Manuel, Pulgar, Antonio, Rauer, Clemens, Alonso Prados, José Luis, Alonso Prados, José L.   +13 more
core   +1 more source