Results 71 to 80 of about 1,586,161 (275)

Synthesis and oral hypoglycemic effect of novel thiazine containing trisubstituted benzenesulfonylurea derivatives

Saudi Pharmaceutical Journal, 2014
A new series of 3-(4-substituted phenyl)-1-(4-(4,6-dimethyl-6H-1,3-thiazin-2-yl)phenylsulfonyl)-1-substituted urea (5a–o) was synthesized by an effectual route via sulfonylcarbamates and explores the novel site for substitution in sulfonylurea as well as
Alok Singh Thakur, Ravitas Deshmukh, Arvind Kumar Jha, P. Sudhir Kumar   +3 more
doaj   +1 more source

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Multifactorial wheat response under Fusarium culmorum, herbicidal, fungicidal and biostimulator treatments on the biochemical and mycotoxins status of wheat

Journal of the Saudi Society of Agricultural Sciences, 2021
A large-scale study under controlled conditions was conducted to estimate the influence of diversified level of biotic: Fusarium culmorum and abiotic factors: herbicide (H; sulfosulfuron), fungicides (F1; cyproconazole + propiconazole), (F2; spiroxamine +
Piotr Iwaniuk, Bozena Lozowicka, Piotr Kaczynski, Rafal Konecki   +3 more
doaj   +1 more source

Artificial intelligence‐assisted nanozyme design for medical and environmental applications

Journal of Intelligent Medicine, EarlyView.
AI‐assisted nanozyme design integrates cross‐source data and machine learning to enable predictive structure‐activity relationships, accelerating intelligent diagnostics, precision therapeutics, and environmental surveillance. Abstract Nanozymes, a class of nanomaterials with intrinsic enzyme‐like catalytic activities, have emerged as promising ...
Xiaolin Guo, Hao Zhang, Zihan Zhao, Qingshan Liu, Jiayi Liu, Jiang Huang, Changlong Liu, Xiaoyu Mu   +7 more
wiley   +1 more source

COST-EFFECTIVENESS ANALYSIS OF INSULIN, SULFONYLUREA, AND SULFONYLUREA– METFORMIN IN TYPE 2 DIABETES MELLITUS

, 2017
Objective: This study aims to compare the cost-effectiveness of insulin therapy, sulfonylureas, and combination of sulfonylureas-metformin in patients with type 2 diabetes mellitus in Sitanala Hospital, Tangerang.Methods: This study employed a cross ...
Endang Laelasari, Rani Sauriasari, Agusdini Banun   +2 more
core   +1 more source

Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hyperglycemia, glucose fluctuations, and thyroid dysfunction contribute to the progression of diabetic nephropathy. This study aimed to investigate the associations of glycemia, glucose variability, and thyroid hormones with albuminuria in patients with type 2 diabetes mellitus (T2DM). In total, 451 T2DM patients were included.
Na Luo, Shang‐Yong Feng, Hui Chen, Dun‐Min She, Yan Liu, Ying Li, Cai‐Feng Yan, Zhen‐Wen Zhang, Jing Chen, Xiao‐Li Cai, Gao‐Yu Zhao, Hui Yu, Yan Wang   +12 more
wiley   +1 more source

A personalized approach to the treatment of neonatal diabetes mellitus caused by a KCNJ11 mutation: clinical observations

Сахарный диабет
Neonatal diabetes mellitus (NDM), or diabetes of the newborn, belongs to the group of monogenic forms of the disease and is characterized by marked genetic polymorphism.
A. S. Severina, А. O. Emelyanov, T. L. Kuraeva, E. A. Sechko, A. N. Zvyagintseva, D. V. Ivanova, M. S. Shamhalova, M. V. Shestakova   +7 more
doaj   +1 more source

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

eLife, 2019
ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis.
Gregory M Martin, Min Woo Sung, Zhongying Yang, Laura M Innes, Balamurugan Kandasamy, Larry L David, Craig Yoshioka, Show-Ling Shyng   +7 more
doaj   +1 more source

Large language models unlock large text corpora in the search for data on medicinal plants and fungi

PLANTS, PEOPLE, PLANET, EarlyView.
Millions of people worldwide depend on plants and fungi for their healthcare needs, yet our understanding of which species are used medicinally—and how—remains fragmented and incomplete. As part of Kew's Plants for Health service, we developed a pipeline to mine large text corpora for information on natural products, initially focusing on the medicinal
Adam Richard‐Bollans, Francesco Civita, Tiziana A. Cossu, Ifra Saifi, Kristina Patmore, Caroline Wilkinson, Bob Allkin   +6 more
wiley   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

Pest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti, Eric L. Patterson, Todd A. Gaines, Aldo Merotto   +3 more
wiley   +1 more source