Results 91 to 100 of about 1,948,666 (273)

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin [PDF]

, 2014
Three series of novel sulfonylurea podophyllotoxin derivatives were designed, synthesized, and evaluated for in vitro cytotoxicity against four tumor cell lines (A-549, DU-145, KB and KBvin). Compounds 14c (IC50: 1.41–1.76 μM) and 14e (IC50: 1.72–2.01 μM)
Wang, Mei Juan, Liu, Ying Qian, Zhang, Zhi Jun, Morris-Natschke, Susan L., Lee, Kuo Hsiung, Wang, Li Ting, Tian, Jing, Yang, Liu, Nan, Xiang   +8 more
core   +1 more source

DiaActive protocol: A randomized controlled trial of cognitive‐motor multicomponent exercise to reduce fall rate in older adults with diabetes

Diabetic Medicine, EarlyView.
Abstract Introduction Older adults with diabetes have an increased risk of falls due to neuropathy, impaired bone health and cardiovascular disease, resulting in significant morbidity and mortality. Conventional fall‐prevention programmes primarily target strength and balance, while cognitive‐motor integration, essential for safe mobility in complex ...
Aksayan Arunanthy Mahalingasivam, Asger Ahlmann Bech, Peter Vestergaard, Martin Grønbech Jørgensen, Nicklas Højgaard‐Hessellund Rasmussen   +4 more
wiley   +1 more source

Ethnicity is associated with variation in diabetes emergency outcomes: Findings from the DEKODE audit and feedback programme

Diabetic Medicine, EarlyView.
Abstract Background Although ethnic disparities in diabetes prevalence and chronic complications are well recognised, their association with acute metabolic emergencies and outcomes is not well established. In this study, we investigated the association between ethnicity and clinical outcomes.
Aspasia Manta, Aqeelah Khatoon, Kalyaani Persad, Nevil C. Philip, Punith Kempegowda, DEVI Collaboration, Amanda Ling Jie Yee, Mariam Idrissi, Sam Sherratt‐Mayhew, Sanna Waheed, Vaishali Limbachia, Sanu Aleyamma Thomas, Tania Kew, Jhanvi Pravesh Sawlani, Joseph Dalzell, Gerry Rayman, Amar Mann, Eleni Armeni, Parijat De, Charlotte Boden, Rajeev Raghavan, Senthilkumar Krishnasamy, Sara Wootton, Alexandra Lubina Solomon, Muhammad Aizaz, Wui Hang Cheung, Hao Wei Tan, Ahmed Iqbal, Daniel Flanagan, Zeenat Banu, Kah Fai Wong, Vilma Ramos, Sathis Kumar, Dintu Mathew, Hafsa Promi, Dawn Marie Mahler, Maryam Mushtag, Noreen Muzaffar, Mohammed Naumann, Niveditha Kuppurajan, Faith Cebet   +40 more
wiley   +1 more source

Response of maize (Zea mays L.) to rimsulfuron under salt conditions

Acta Societatis Botanicorum Poloniae, 2011
Investigations were carried out to determine the possible interaction between salinity (60 mmol*dm-3 NaCl) and phytotoxicity of herbicide Titus 25 DF (sulfonylurea herbicide containing active ingredient rimsulfuron).
Elżbieta Sacała, Anna Demczuk, Tomasz Michalski   +2 more
doaj   +1 more source

New type of Sulfonylureas as an AHAS enzyme inhibitor: Calculation in Molecular Docking

, 2021
It is aimed to substitute the pyrimidinone group instead of the pyrimidine group in sulfonylurea herbicides sold in the market. Because, according to the literature data (and patents received), the pyrimidinone group shows herbicidal activity. Our aim is
Canbolat, Nüveyre, Karacan, Nurcan
core   +1 more source

Kidney Outcomes With GLP‐1 Receptor Agonists and Tirzepatide Versus Finerenone in Type 2 Diabetes and Chronic Kidney Disease: A Real‐World Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To compare kidney outcomes after GLP‐1 receptor agonists (RA) or tirzepatide (GLP‐1/GIP RAs) versus finerenone initiation in adults with Type 2 diabetes (T2D) and moderate chronic kidney disease (CKD). Methods In a retrospective TriNetX global network study (July 2021–November 2025), adults with T2D and CKD stages 3–4 initiating GLP‐1/GIP ...
Dvora R. Sehtman‐Shachar, Alisa Fishkin, Gil Leibowitz, Ofri Mosenzon, Meir Schechter, Genya Aharon‐Hananel   +5 more
wiley   +1 more source

Cytochrome P450 2C9*2 and *3 polymorphisms and the dose and effect of sulfonylurea in type II diabetes mellitus

, 2007
Sulfonylurea hypoglycemics are mainly metabolized by the cytochrome P450 2C9 ( CYP2C9) enzyme. The CYP2C9*2 and *3 polymorphisms encode proteins with less enzymatic activity and are correlated with elevated serum levels of sulfonylurea, as demonstrated ...
Stricker, Bruno, Visser, Loes, Becker, Matthijs, Hofman, Bert, Trienekens, PH, van Schaik, Ron, LE Visser, PH Trienekens, RHN van Schaik, A Hofman, ML Becker, BHCh Stricker   +11 more
core   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Sulfonylurea-induced hypoglycaemia: use of octreotide.

, 2009
Sulfonylurea compounds are commonly used to treat type 2 diabetes mellitus. The case of an old alcoholic addicted diabetic patient treated with gliquidone developing recurrent and prolonged hypoglycaemias refractory to dextrose administration is related.
Hanchard, B, Vanpee, Dominique, Boulouffe, Caroline   +2 more
core