Results 161 to 170 of about 3,697,166 (278)

Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Combining PTP1B inhibitors of distinct kinetic mechanisms determines their pharmacological outcome. Integrating enzyme kinetics, docking, molecular dynamics, and membrane‐permeability simulations, we show that mechanistically compatible pairs (competitive + competitive; uncompetitive + mixed) yield additivity, whereas competitive + uncompetitive ...
Jonathan Trapala, Laura I. Álvarez‐Añorve, Nathaly Vasquez‐Martínez, Erika Chavira‐Suárez, Luz Vásquez‐Bochm, Deyamira Matuz‐Mares, Francisco Cortés‐Benítez, Martin González‐Andrade   +7 more
wiley   +1 more source

Blood Pressure Status Modulates the Therapeutic Response to Sodium-Glucose Cotransporter 2 Inhibitors in Diabetic Macular Edema: A Post Hoc Subgroup Analysis of the COMET Trial. [PDF]

J Diabetes
Ishibashi R, Koshizaka M, Takatsuna Y, Tatsumi T, Baba T, Yamamoto S, Yokote K.   +6 more
europepmc   +1 more source

Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms

Advanced Biology, Volume 10, Issue 8, August 2026.
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei   +3 more
wiley   +1 more source

Recent Advances in Glimepiride Solubility Improvement: A Focus on Formulation Technologies - A Narrative Review. [PDF]

Int J Nanomedicine
Fiftianingrum V, Sopyan I, Megantara S, Suhandi C.   +3 more
europepmc   +1 more source

Angiotensin receptor blockers and dementia risk in older adults: A target trial emulation

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Whether antihypertensive drug class influences dementia risk beyond blood pressure lowering remains uncertain. METHODS We emulated a target trial comparing new initiation of angiotensin receptor blockers (ARBs) versus calcium channel blockers (CCBs) among dementia‐free adults aged ≥65 years in a nationwide Japanese database ...
Hisashi Noma, Hiroshi Sunada, Taiki Sugimoto, Takao Fujisawa, Futoshi Oda, Megumi Maeda, Haruhisa Fukuda   +6 more
wiley   +1 more source

Stacked mutations in multi-copy AHAS genes enhance sulfonylurea herbicide resistance in soybean. [PDF]

Plant J
Park K, Kim HJ, Choi Y, Kang M, Shin Y, Lim H, Choi M, Park H, Park S, Jeong D, Chung YS, Kim SG.   +11 more
europepmc   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2741-2755, August 2026.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Influences of Fasting on Elimination of Sulfonylurea Compounds from Plasma in Rabbits

YAKUGAKU ZASSHI, 1983
S, Tsukiai, H, Fukuchi, M, Yoshida, M, Kumagai, T, Kitaura, S, Arai, N, Yata   +6 more
openaire   +3 more sources

Gabapentin‐Induced Hypoglycemia in a Patient With Pre‐Diabetes: A Case Report and Review of the Literature

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Gabapentin, a γ‐aminobutyric acid (GABA) analogue, is widely prescribed for neuropathic pain and partial seizures. While common adverse effects include somnolence and dizziness, hypoglycemia is rarely reported. A 76‐year‐old woman with hypertension, dyslipidemia, hypothyroidism, and pre‐diabetes (HbA1c 6%) developed recurrent symptomatic ...
Reem Hussain Alamri, Abdullah Ali Alshamrani, Hesham E. Mawar, Suhaib Radi   +3 more
wiley   +1 more source

Comparative effects of second-line oral antidiabetic medications on atrial fibrillation risk in patients with type 2 diabetes: a nationwide retrospective cohort study. [PDF]

Cardiovasc Diabetol
Heo GY, Heo SJ, Ko B, Ko YE, Koh HB, Park CH, Park JT, Han SH, Yoo TH, Kang SW, Han M, Kim HW.   +11 more
europepmc   +1 more source