Results 201 to 210 of about 1,377,243 (284)

Influences of Fasting on Elimination of Sulfonylurea Compounds from Plasma in Rabbits

YAKUGAKU ZASSHI, 1983
S, Tsukiai, H, Fukuchi, M, Yoshida, M, Kumagai, T, Kitaura, S, Arai, N, Yata   +6 more
openaire   +3 more sources

Waist‐to‐height ratio and renal dysfunction as independent correlates of low handgrip strength in patients with type 2 diabetes

Journal of Diabetes Investigation, Volume 17, Issue 9, Page 1538-1547, September 2026.
In 1,468 patients with type 2 diabetes, central obesity (WHtR >0.5) neutralizes the protective effects of higher BMI on muscle strength. Concurrently, visceral adiposity and CKD impose an additive threat, maximizing low handgrip strength risk (aOR = 1.74). Combining WHtR and renal tracking optimizes clinical sarcopenia screening.
Shing‐Hua Chen, Chen‐Kai Chou, Shao‐Wen Weng, Jung‐Fu Chen, Feng‐Chih Shen   +4 more
wiley   +1 more source

Recent Advances in Glimepiride Solubility Improvement: A Focus on Formulation Technologies - A Narrative Review. [PDF]

Int J Nanomedicine
Fiftianingrum V, Sopyan I, Megantara S, Suhandi C.   +3 more
europepmc   +1 more source

Clinical characteristics of Sarcopenic obesity in Japanese people with type 2 diabetes: A post hoc analysis of the sub‐cohort iDIAMOND study

Journal of Diabetes Investigation, Volume 17, Issue 9, Page 1565-1574, September 2026.
Among participants aged 40–75 years, sarcopenic obesity was observed in 4.9% of those with T2D and 0.5% of non‐D individuals. Sarcopenic obesity is more prevalent in individuals with T2D and is associated with impaired physical QOL, reduced walking ability, and increased falls.
Hiroyasu Mori, Kasei Ko, Satoko Notomi, Sumiko Yoshida, Tetsuyuki Yasuda, Yutaka Umayahara, Sayoko Shimizu, Kayoko Ryomoto, Kazutomi Yoshiuchi, Saeko Osawa, Tsunehiko Yamamoto, Akio Kuroda, Munehide Matsuhisa   +12 more
wiley   +1 more source

Stacked mutations in multi-copy AHAS genes enhance sulfonylurea herbicide resistance in soybean. [PDF]

Plant J
Park K, Kim HJ, Choi Y, Kang M, Shin Y, Lim H, Choi M, Park H, Park S, Jeong D, Chung YS, Kim SG.   +11 more
europepmc   +1 more source

Real‐World Effectiveness and Safety of iGlarLixi in People With Type 2 Diabetes in LATAM Region: A Subanalysis of the SUCCESS Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8724-8728, September 2026.
Juan Manuel Arteaga‐Diaz, Jose Luis Torres‐Grajales, Leobardo Sauque‐Reyna, Carlos Salamanca‐Carrillo, Luis Anguiano‐Medrano   +4 more
wiley   +1 more source

Comparative effects of second-line oral antidiabetic medications on atrial fibrillation risk in patients with type 2 diabetes: a nationwide retrospective cohort study. [PDF]

Cardiovasc Diabetol
Heo GY, Heo SJ, Ko B, Ko YE, Koh HB, Park CH, Park JT, Han SH, Yoo TH, Kang SW, Han M, Kim HW.   +11 more
europepmc   +1 more source

Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Combining PTP1B inhibitors of distinct kinetic mechanisms determines their pharmacological outcome. Integrating enzyme kinetics, docking, molecular dynamics, and membrane‐permeability simulations, we show that mechanistically compatible pairs (competitive + competitive; uncompetitive + mixed) yield additivity, whereas competitive + uncompetitive ...
Jonathan Trapala, Laura I. Álvarez‐Añorve, Nathaly Vasquez‐Martínez, Erika Chavira‐Suárez, Luz Vásquez‐Bochm, Deyamira Matuz‐Mares, Francisco Cortés‐Benítez, Martin González‐Andrade   +7 more
wiley   +1 more source

Sulfonylurea Bioisosteres of Sulfonic Acid in JFD 00458‐Based ST6GAL1 Inhibitors Enhance Membrane Permeability

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
ST6GAL1 sialylates glycoconjugates in the Golgi, modulating immune recognition and enabling tumor immune evasion. To effectively reach ST6GAL1, inhibitors should demonstrate good membrane permeability. Based on nonpermeable hit JFD 00458, we developed sulfonylurea analogs achieving increased membrane permeability and potency.
Natan Koraj, Sushmaa Dangudubiyyam, Adelyn M. Betances‐Mora, Ema Faganeli, Anne Harduin‐Lepers, Jesús Angulo, Tan Khanh Nguyen, María Bort‐Griñó, Ramon Hurtado‐Guerrero, Marko Anderluh   +9 more
wiley   +1 more source

Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure. [PDF]

Nutr Diabetes
Park JG, Kim M, Yoo S, Hwang SW, Mok J, Park J, Kang KW.   +6 more
europepmc   +1 more source