ABSTRACT Objective Although concerns have been raised that glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) may increase the risk of bowel obstruction or ileus, evidence remains inconclusive. In this context of uncertainty, we examined the frequency and determinants of GLP‐1RA discontinuation after hospitalization for bowel obstruction/ileus ...
Yuichiro Matsuo +3 more
wiley +1 more source
Burden and Risk Factors of CGM‐Detected Hypoglycemia in Older Adults With Type 2 Diabetes
Among older adults with diabetes using insulin or sulfonylureas, the median time spent in hypoglycemia was 3.4% and ~66% of participants exceeded the target of < 1% time with CGM glucose < 70 mg/dL. ABSTRACT Background Comprehensive data on the burden of biochemical hypoglycemia in older adults with type 2 diabetes are lacking.
Michael Fang +6 more
wiley +1 more source
Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury
OBJECTIVES: Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies.
Chang, Chung-Chou H +23 more
core +1 more source
The Generics Revolution and the New Economic Geography of the Global Pesticide Industry
ABSTRACT The global pesticide industry transformed from one dominated by patented products and legacy multinationals with strong manufacturing bases in the United States and EU to one dominated by generic products produced in India and China. We use proprietary market research data, data from regulatory filings, industry press and bilateral trade data ...
Christian Berndt +4 more
wiley +1 more source
The Sulfonylurea Drug, Glimepiride, Stimulates Glucose Transport, Glucose Transporter Translocation, and Dephosphorylation In Insulin-Resistant Rat Adipocytes In Vitro [PDF]
Wied, Susanne, Müller, Günter
core +1 more source
The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATP) blockers, on insulin secretion and ...
Berggren, PO +20 more
core +1 more source
The Capital–Labour–State Dynamics of Herbicide Adoption in Rainfed India
ABSTRACT This paper engages debates around the capital–labour–state dynamics of agrarian transitions to address the oft‐studied but still little‐understood question of why farmers adopt herbicides when they do. Over the last several years, smallholder farmers in India have begun using the herbicide bispyribac sodium at breakneck speeds, particularly in
Carly Nichols, Nidhi Kumari
wiley +1 more source
Habitual fasting duration and accelerated multimorbidity in older adults
Abstract Background Prolonged fasting has been linked to metabolic benefits in younger adults, but its effects on chronic diseases in older populations remain unclear. Objective To examine the association between habitual fasting duration and 15‐year chronic disease accumulation in older adults, overall, within organ systems, and between age groups ...
Luis Kalmbach +6 more
wiley +1 more source
Estudo do efeito e do mecanismo de ação das sulfonamidas e acilhidrazonas sintéticas na homeostasia da glicose [PDF]
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2014.Durante as últimas décadas, observou-se um aumento surpreendente na prevalência do diabetes melito (DM)
Frederico, Marisa Jádna Silva
core
Drug‐Induced Sialolithiasis—A Big‐Data Retrospective Study
ABSTRACT Background Sialolithiasis pathophysiology is multifactorial, with systemic medications often hypothesised as a key contributor, particularly in older adults (Drug‐Induced Sialolithiasis). However, robust evidence supporting this theory is limited.
Gal Avishai +5 more
wiley +1 more source

