Results 51 to 60 of about 1,586,237 (267)

In Silico Study of New Sulfonylurea Analogs as Potential Antidiabetic Agents: ADMET, Molecular Docking and Dynamics, MM-GBSA and DFT Approach

Journal of Chemistry
Type 2 diabetes mellitus (T2DM) remains one of the leading causes of death globally. Current treatments of this disease involve using sulfonylurea, which is associated with cardiovascular risk and insulin resistance, among others.
Vhushavhelo Musinyali, Kabelo P. Mokgopa, Simon S. Mnyakeni-Moleele, Tendamudzimu Tshiwawa, Ndivhuwo R. Tshiluka   +4 more
doaj   +1 more source

Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors

European Journal of Medicinal Chemistry Reports, 2023
Overactivated NLRP3 inflammasome has been shown to associate with an increasing number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1-catalyzed formation of active pro-inflammatory cytokines (IL-1β and IL-18) resulting ...
Pritam Thapa, Sunil P. Upadhyay, Vikas Singh, Varun C. Boinpelly, Jianping Zhou, David K. Johnson, Prajwal Gurung, Eung Seok Lee, Ram Sharma, Mukut Sharma   +9 more
doaj   +1 more source

Trends in publicly subsidized and private access to GLP‐1 medicines indicated for type 2 diabetes in Australia, 2020–2025

British Journal of Clinical Pharmacology, EarlyView.
Aims GLP‐1 medicines provide substantial cardio‐renal benefits for type 2 diabetes (T2D) and are increasingly used for weight loss. Most high‐income countries subsidize access for T2D with restrictions; use outside of these restrictions occurs through private prescriptions. Despite strong consumer demand, the extent of private access to GLP‐1 medicines
Michael O. Falster, Juliana de Oliveira Costa, Tamara Y. Milder, Joanne Carson, Cade Shadbolt, Brendon L. Neuen, Clare Arnott, Andrew Wilson, Min Jun, Nicole Pratt, Sallie‐Anne Pearson   +10 more
wiley   +1 more source

Implication of sulfonylurea derivatives as prospective inhibitors of human carbonic anhydrase II

, 2018
Selective carbonic anhydrase (CA) inhibitors have gained a lot of importance owing to the implication of specific isoforms of CA in certain diseases like glaucoma, leukemia, cystic fibrosis, and epilepsy.
Danish Idrees, Shahzaib Ahamad, Datta, Bhaskar, Hadianawala, Murtuza, Imtaiyaz Hassan, Md, Amarjyoti Das Mahapatra, Sonam Roy, Ahamad, Shahzaib, Khan, Parvez, Idrees, Danish, Mahapatra, Amarjyoti Das, Bhaskar Datta, Parvez Khan, Md. Imtaiyaz Hassan, Roy, Sonam, Murtuza Hadianawala   +15 more
core   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Population attributable fraction of associated factors to adherence to blood glucose self-monitoring in diabetic type 2 patients treated with insulin or sulfonylureas/meglitinides: The results of DiaCare study in Iran

Journal of Education and Health Promotion
BACKGROUND: Self-monitoring of blood glucose (SMBG) is a part of diabetes management. Numerous investigations have demonstrated inadequate adherence to SMBG.
Amin Mohammadi, Gita Shafiee, Alireza Olyaeemanesh, Rajabali Daroudi, Amirhossein Aghakhani, Ensieh Nasli-Esfahani, Farideh Razi, Ramin Heshmat, Amirhossein Takian   +8 more
doaj   +1 more source

A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agen. [PDF]

PLoS ONE, 2016
Insulin secretagogues are used for treatment of type 2 diabetes. We attempted to discover novel small molecules to stimulate insulin secretion by using in silico similarity search using sulfonylureas as query, followed by measurement of insulin secretion.
Kenji Sugawara, Kohei Honda, Yoshie Reien, Norihide Yokoi, Chihiro Seki, Harumi Takahashi, Kohtaro Minami, Ichiro Mori, Akio Matsumoto, Haruaki Nakaya, Susumu Seino   +10 more
doaj   +1 more source

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah, Junsung Nam, Jung Wook Youn, Yun Mi Yu, Soyoung Kang   +4 more
wiley   +1 more source

Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

Pharmaceuticals, 2022
The low solubility of active pharmaceutical ingredients (APIs) is a problem in pharmaceutical development. Several methodologies can be used to improve API solubility, including the use of eutectic systems in which one of the constituents is the API ...
Mafalda C. Sarraguça, Paulo R. S. Ribeiro, Cláudia Nunes, Catarina Leal Seabra   +3 more
doaj   +1 more source