Results 141 to 150 of about 1,586,161 (275)

Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury

, 2017
OBJECTIVES: Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies.
Chang, Chung-Chou H, Wallisch, Jessica S, Ruchira M. Jha, Ava M. Puccio, Patrick M. Kochanek, Keri L. Janesko-Feldman, Bradley J. Molyneaux, Sherry Hsiang-Yi Chou, Chung-Chou H. Chang, David O. Okonkwo, Jha, Ruchira M, Jessica S. Wallisch, Shutter, Lori A, Lori A. Shutter, Janesko-Feldman, Keri L, Chou, Sherry Hsiang-Yi, Molyneaux, Bradley J, Okonkwo, David O, Samuel M. Poloyac, Zusman, Benjamin E, Benjamin E. Zusman, Puccio, Ava M, Kochanek, Patrick M, Poloyac, Samuel M   +23 more
core   +1 more source

Person‐Reported and Continuous Glucose Monitoring (CGM) Recorded Hypoglycaemia in People With Insulin‐Treated Type 2 Diabetes and Mild to Moderate Chronic Kidney Disease; Post Hoc Analysis From the Hypo‐METRICS Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10664-10669, November 2026.
ABSTRACT Background and Aims People with diabetes and chronic kidney disease (CKD) may be at increased risk of iatrogenic hypoglycaemia. We compared rates of sensor‐detected (SDH) and person‐reported hypoglycaemia (PRH) in people with insulin‐treated Type 2 diabetes (T2D) with and without CKD in the Hypo‐METRICS study.
Julie M. B. Brøsen, Daniel Malmsiø, Patrick Divilly, Gilberte Martine‐Edith, Natalie Zaremba, Namam Ali, Rory J. McCrimmon, Simon Heller, Mark Evans, Bastiaan de Galan, Julia K. Mader, Eric Renard, Allan A. Vaag, Pratik Choudhary, Ulrik Pedersen‐Bjergaard, on behalf of the HypoRESOLVE Consortium, Andrew Pernet, Amy Aldridge, Marcia Henderson‐Wilson, Pernille Banck‐Petersen, Rikke Carstensen, Charlotte Hansen, Sharon Caunt, Sue Hudson, Chloe Husband, Fahad Arshad, Anne Farret, Anne‐Marie Marteil‐Oudrer, Manal Shbat, Lisa Crespy, Jenny Constanza Thibout, Anja Rasing, Jesper Walburgh Schimidt, Daniel Loewenstein, Renate Huijsmans, Pieter Drijver, Daniel Chapman, Jane Kennet, Anna Barnett, Jackie Lindsay   +39 more
wiley   +1 more source

Genetic and Clinical Determinants of Variation in Drug Response in Type 2 Diabetes: Insights From the Scottish and UK Biobank Cohorts

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10780-10794, November 2026.
ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
S. Garg, R. Kitchen, R. Gupta, L. Donnelly, E. R. Pearson   +4 more
wiley   +1 more source

Estudo do efeito e do mecanismo de ação das sulfonamidas e acilhidrazonas sintéticas na homeostasia da glicose [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2014.Durante as últimas décadas, observou-se um aumento surpreendente na prevalência do diabetes melito (DM)
Frederico, Marisa Jádna Silva
core  

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach

Clinical Epidemiology, 2018
John M Dennis,1 Beverley M Shields,2 Angus G Jones,2 Ewan R Pearson,3 Andrew T Hattersley,2 William E Henley1 On behalf of the MASTERMIND consortium 1Health Statistics Group, University of Exeter Medical School, Exeter, UK; 2National Institute for ...
Dennis JM, Shields BM, Jones AG, Pearson ER, Hattersley AT, Henley WE   +5 more
doaj  

Exploratory Analysis of Type 2 Diabetes Mellitus Metabolic Phenotypes and Their Association With Vitamin D Status in Primary Care Patients

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10603-10614, November 2026.
ABSTRACT Aims This study aimed to perform an exploratory characterisation of metabolic phenotypes in primary care patients with type 2 diabetes mellitus (T2DM), using a predefined approach and examine their association with vitamin D status. Materials and Methods This cross‐sectional study included 178 participants randomly selected in Sergipe, Brazil.
Liliane Viana Pires, Matheus Menezes‐Santos, Andréa Costa Goes, Heitor Siqueira Ribeiro, Luana Ferreira Alves, Beatriz Cruz dos Santos, Jéssyca Teles Barreto, Roberta Cristina Vieira Meneses, Ana Mara de Oliveira e Silva, Ana Hermínia Andrade e Silva, Sadraque Eneas de Figueiredo Lucena   +10 more
wiley   +1 more source

Reactions of Some Cyclomanganated Compounds with C-Nitroso Compounds, Allenes, and Ketenimines [PDF]

, 2008
eta2-(5-Methoxy-2-acetylphenyl)tetracarbonylmanganese (30) was reacted with 2-methyl-2-nitrosopropane (31) to form 2-acetyl-5-methoxy-N-(tert-butyl)aniline(43) in low yield.
Revell, John Bernard
core  

Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective

Immunology, Volume 179, Issue 3, Page 390-405, November 2026.
Peripheral blood mononuclear cells (PBMCs) from individuals with metabolic syndrome (MetS) who were not using glucose‐and/or lipid lowering medication (GLLM) exhibited a broader cytokine production profile after in vitro antigen‐specific stimulation than PBMCs from individuals with MetS using such medications and from healthy donors.
Isabela Ghetti Macedo Isaac, Carolina do Prado Servian, Fernanda de Oliveira Feitosa de Castro, João Lucas Lima Calandrini de Azevedo, Ronaldo Moraes Preto, Miriam Leandro Dorta, Daniela Espíndola Antunes, Simone Gonçalves Fonseca   +7 more
wiley   +1 more source

Habitual fasting duration and accelerated multimorbidity in older adults

Journal of Internal Medicine, Volume 300, Issue 5, Page 642-658, November 2026.
Abstract Background Prolonged fasting has been linked to metabolic benefits in younger adults, but its effects on chronic diseases in older populations remain unclear. Objective To examine the association between habitual fasting duration and 15‐year chronic disease accumulation in older adults, overall, within organ systems, and between age groups ...
Luis Kalmbach, David Abbad‐Gomez, Giorgi Beridze, Fernando Rodríguez‐Artalejo, Davide Liborio Vetrano, Amaia Calderón‐Larrañaga, Adrián Carballo‐Casla   +6 more
wiley   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, Volume 13, Issue 56, 9 October 2026.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source