Results 21 to 30 of about 5,240 (162)

Successful sulfonylurea treatment in a patient with permanent neonatal diabetes mellitus with a novel mutation [PDF]

Korean Journal of Pediatrics, 2015
Permanent neonatal diabetes mellitus refers to diabetes that occurs before the age of 6 months and persists through life. It is a rare disorder affecting one in 0.2-0.5 million live births.
Sung Yeon Ahn, Gu-Hwan Kim, Han-Wook Yoo
doaj   +1 more source

In Silico Study of Mangostin Compounds and Its Derivatives as Inhibitors of α-Glucosidase Enzymes for Anti-Diabetic Studies

Biology, 2022
Diabetes is a chronic disease with a high mortality rate worldwide and can cause other diseases such as kidney damage, narrowing of blood vessels, and heart disease. The concomitant use of drugs such as metformin, sulfonylurea, miglitol, and acarbose may
Ahmad Fariz Maulana, Sriwidodo Sriwidodo, Yaya Rukayadi, Iman Permana Maksum   +3 more
doaj   +1 more source

Insulinoma Causing Hypoglycemia in a Patient with Type 2 Diabetes

Journal of the Formosan Medical Association, 2007
Insulinoma in a patient with pre-existing diabetes is extremely rare. A 74-year-old woman with type 2 diabetes mellitus who had been treated with a sulfonylurea for 6 years began experiencing frequent episodes of hypoglycemia.
Wei-Yi Lei, Tsang-En Wang, Tien-Ling Chen, Wen-Hsiung Chang, Tsen-Long Yang, Cheng-Yi Wang   +5 more
doaj   +1 more source

Synthesis and Characterization of Related Substances of Torasemide

Pharmaceutical Fronts, 2022
Torasemide, a pyridine-3-sulfonylurea derivative, is a high-efficiency loop diuretic. During the process development of torasemide, five process-related substances, which have been specified in the pharmacopeia, would be produced.
Jiong Chen, Wei Ming, De-Hua Fan, Shuang-Xi Gu   +3 more
doaj   +1 more source

SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2013
In order to produce potent new leads for antidiabetic drugs, a new series of isoindoline-1,3-dione analogues bearing aryl sulfonylurea moieties were synthesized and screened for their antihyperglycemic activity.
Ibrahim Eissa
doaj   +1 more source

Methyl Caffeate Isolated from the Flowers of Prunus persica (L.) Batsch Enhances Glucose-Stimulated Insulin Secretion

Biomolecules, 2021
Phenolic compounds from natural products are considered effective enhancers of insulin secretion to prevent and treat type 2 diabetes (T2DM). The flowers of Prunus persica (L.) Batsch also contain many phenolic compounds.
Dahae Lee, Yutong Qi, Ranhee Kim, Jungbin Song, Hocheol Kim, Hyun Young Kim, Dae Sik Jang, Ki Sung Kang   +7 more
doaj   +1 more source

Tetracarpidium conophorum seed extract reduces intestinal absorption, and increases cellular trapping of glucose

Bulletin of the National Research Centre, 2021
Background Tetracarpidium conophorum is one of the numerous folklore medicinal plants for managing diabetes but the mode of action and bioactive compounds responsible for the antihyperglycemic property are missing in literatures.
Bamidele Stephen Ajilore, Olubukola Sinbad Olorunnisola, Abiodun Olusoji Owoade   +2 more
doaj   +1 more source

Assessing the environmental risks of sulfonylurea pollutants: Insights into the risk priority and structure-toxicity relationships

Ecotoxicology and Environmental Safety
Sulfonylureas are widely used herbicides globally; however, the health risks associated with exposure to these compounds are poorly understood. This study used fuzzy clustering to categorize 44 sulfonylurea compounds into three risk priority levels (I ...
Zhi-Cong He, Tao Zhang, Xin-Fang Lu, Rui Li, Wei Peng, Fei Ding   +5 more
doaj   +1 more source

Screening of Some Sulfonamide and Sulfonylurea Derivatives as Anti-Alzheimer’s Agents Targeting BACE1 and PPARγ

Journal of Chemistry, 2020
In the last few decades, Alzheimer’s disease (AD) has emerged as a serious global problem, and it has been considered as the most common type of dementia.
Ning Li, Yan Wang, Wensheng Li, Haiyan Li, Liu Yang, Jun Wang, Hazem A. Mahdy, Ahmed B. M. Mehany, Dareen A. Jaiash, Eman Y. Santali, Ibrahim H. Eissa   +10 more
doaj   +1 more source

Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1

Pharmaceuticals, 2020
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, selectivity and potency of first ...
Sonam Roy, Amarjyoti Das Mahapatra, Taj Mohammad, Preeti Gupta, Mohamed F. Alajmi, Afzal Hussain, Md. Tabish Rehman, Bhaskar Datta, Md. Imtaiyaz Hassan   +8 more
doaj   +1 more source