Results 31 to 40 of about 1,671,881 (203)

Additional Effect of Dietary Fiber in Patients with Type 2 Diabetes Mellitus Using Metformin and Sulfonylurea: An Open-Label, Pilot Trial [PDF]

Diabetes & Metabolism Journal, 2019
BackgroundMetformin, sulfonylurea, and dietary fiber are known to affect gut microbiota in patients with type 2 diabetes mellitus (T2DM). This open and single-arm pilot trial investigated the effects of the additional use of fiber on glycemic parameters,
Seung-Eun Lee, Yongbin Choi, Ji Eun Jun, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Gwang Pyo Ko, Moon-Kyu Lee   +7 more
doaj   +1 more source

Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents

Molecules, 2015
Sulphonylurea compounds have versatile activities such as antidiabetic, diuretic, herbicide, oncolytic, antimalarial, antifungal and anticancer. The present study describes the design, synthesis and in vivo testing of novel glycosylated aryl sulfonylurea
Ghadeer A. R. Y. Suaifan, Mayadah B. Shehadeh, Rula M. Darwish, Hebah Al-Ijel, Vincenzo Abbate   +4 more
doaj   +1 more source

Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase [PDF]

, 2003
Acetohydroxyacid synthase (AHAS) (acetolactate synthase, EC 4.1.3.18) catalyzes the first step in branchedchain amino acid biosynthesis and is the target for sulfonylurea and imidazolinone herbicides.
Pang, S. S., Duggleby, R. G., Luke W. Guddat, Guddat, L. W., Siew Siew Pang, Ronald G. Duggleby, Duggleby, R.G.   +6 more
core   +1 more source

Novel Sulfonylurea Derivatives as Potential Antimicrobial Agents: Chemical Synthesis, Biological Evaluation, and Computational Study

Antibiotics, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide health threat and has already tormented humanity during its long history, creating an urgent need for the development of new classes of antibacterial agents.
Fan-Fei Meng, Ming-Hao Shang, Wei Wei, Zhen-Wu Yu, Jun-Lian Liu, Zheng-Ming Li, Zhong-Wen Wang, Jian-Guo Wang, Huan-Qin Dai   +8 more
doaj   +1 more source

Successful sulfonylurea treatment in a patient with permanent neonatal diabetes mellitus with a novel mutation [PDF]

Korean Journal of Pediatrics, 2015
Permanent neonatal diabetes mellitus refers to diabetes that occurs before the age of 6 months and persists through life. It is a rare disorder affecting one in 0.2-0.5 million live births.
Sung Yeon Ahn, Gu-Hwan Kim, Han-Wook Yoo
doaj   +1 more source

Insulinoma Causing Hypoglycemia in a Patient with Type 2 Diabetes

Journal of the Formosan Medical Association, 2007
Insulinoma in a patient with pre-existing diabetes is extremely rare. A 74-year-old woman with type 2 diabetes mellitus who had been treated with a sulfonylurea for 6 years began experiencing frequent episodes of hypoglycemia.
Wei-Yi Lei, Tsang-En Wang, Tien-Ling Chen, Wen-Hsiung Chang, Tsen-Long Yang, Cheng-Yi Wang   +5 more
doaj   +1 more source

In Silico Study of Mangostin Compounds and Its Derivatives as Inhibitors of α-Glucosidase Enzymes for Anti-Diabetic Studies

Biology, 2022
Diabetes is a chronic disease with a high mortality rate worldwide and can cause other diseases such as kidney damage, narrowing of blood vessels, and heart disease. The concomitant use of drugs such as metformin, sulfonylurea, miglitol, and acarbose may
Ahmad Fariz Maulana, Sriwidodo Sriwidodo, Yaya Rukayadi, Iman Permana Maksum   +3 more
doaj   +1 more source

Synthesis and Characterization of Related Substances of Torasemide

Pharmaceutical Fronts, 2022
Torasemide, a pyridine-3-sulfonylurea derivative, is a high-efficiency loop diuretic. During the process development of torasemide, five process-related substances, which have been specified in the pharmacopeia, would be produced.
Jiong Chen, Wei Ming, De-Hua Fan, Shuang-Xi Gu   +3 more
doaj   +1 more source

Sulfonylurea is associated with higher risks of ventricular arrhythmia or sudden cardiac death compared with metformin: A population-based cohort study [PDF]

, 2022
Background Commonly prescribed diabetic medications such as metformin and sulfonylurea may be associated with different arrhythmogenic risks. This study compared the risk of ventricular arrhythmia or sudden cardiac death between metformin and ...
Jeremy Man Ho Hui, Danish Iltaf Satti, Tong Liu, Shuk Han Cheng, Pias Tang Hoi Kiu, Ian Chi Kei Wong, Wing Tak Wong, Teddy Tai Loy Lee, Yan Hiu Athena Lee, Bernard Man Yung Cheung, Gary Tse, Yuki Ka Ling Shum, Jeffrey Shi Kai Chan, Abraham Ka Chung Wai   +13 more
core  

SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2013
In order to produce potent new leads for antidiabetic drugs, a new series of isoindoline-1,3-dione analogues bearing aryl sulfonylurea moieties were synthesized and screened for their antihyperglycemic activity.
Ibrahim Eissa
doaj   +1 more source