Results 41 to 50 of about 1,671,881 (203)

Synthesis and vasodilator activity of new 1,4-dihyropyridines bearing sulfonylurea, urea and thiourea moieties [PDF]

, 2019
peer reviewedAbstract: Some new 1,4-dihydropyridines bearing sulfonylurea, urea and thiourea moieties were synthesized and pharmacologically evaluated for their vasodilator activity, comparatively to nifedipine and diazoxide.
Belghobsi, Mebrouk, De Tullio, Pascal, Khelili, Smail, Faury, Gilles, Stiti, Mohamed Zakaria, Pirotte, Bernard, Habila, Tahir, Goffin, Eric   +7 more
core   +1 more source

Methyl Caffeate Isolated from the Flowers of Prunus persica (L.) Batsch Enhances Glucose-Stimulated Insulin Secretion

Biomolecules, 2021
Phenolic compounds from natural products are considered effective enhancers of insulin secretion to prevent and treat type 2 diabetes (T2DM). The flowers of Prunus persica (L.) Batsch also contain many phenolic compounds.
Dahae Lee, Yutong Qi, Ranhee Kim, Jungbin Song, Hocheol Kim, Hyun Young Kim, Dae Sik Jang, Ki Sung Kang   +7 more
doaj   +1 more source

Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea [PDF]

, 2022
The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas
Sauriasari, Rani, Rachman, Abu, Syafhan, Nadia Farhanah, Prawiroharjo, Pukovisa, Risni, Hindun Wilda   +4 more
core   +17 more sources

Tetracarpidium conophorum seed extract reduces intestinal absorption, and increases cellular trapping of glucose

Bulletin of the National Research Centre, 2021
Background Tetracarpidium conophorum is one of the numerous folklore medicinal plants for managing diabetes but the mode of action and bioactive compounds responsible for the antihyperglycemic property are missing in literatures.
Bamidele Stephen Ajilore, Olubukola Sinbad Olorunnisola, Abiodun Olusoji Owoade   +2 more
doaj   +1 more source

Structure-activity relationships for a new family of sulfonylurea herbicides

, 2005
Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) catalyzes the first common step in branched-chain amino acid biosynthesis. The enzyme is inhibited by several chemical classes of compounds and this inhibition is the basis of action of the sulfonylurea and ...
Lee, Yu-Ting, Ma, Zheng-Ming, Wang, Bao-Lei, Jiang, Lin, Li, Zheng-Ming, Guddat, Luke W., Pang, Siew Siew, Duggleby, Ronald G., Wang, Jian-Guo   +8 more
core   +1 more source

Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1

Pharmaceuticals, 2020
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, selectivity and potency of first ...
Sonam Roy, Amarjyoti Das Mahapatra, Taj Mohammad, Preeti Gupta, Mohamed F. Alajmi, Afzal Hussain, Md. Tabish Rehman, Bhaskar Datta, Md. Imtaiyaz Hassan   +8 more
doaj   +1 more source

Design, Synthesis, Molecular Modeling and Anti-Hyperglycemic Evaluation of Quinazoline-Sulfonylurea Hybrids as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Sulfonylurea Receptor (SUR) Agonists

, 2022
New quinazoline-sulfonylurea hybrids were prepared and examined for their in vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as a reference drug.
Mohamed F. Zayed, Alshaeri, Heba K., Bamanie, Faida H., Moudi M. Alasmari, Mohamed Ayman El-Zahabi, Faida H. Bamanie, Mohamed Moustafa, Zohair Al-Marzooki, El-Zahabi, Mohamed Ayman, Zayed, Mohamed F., Moustafa, Mohamed, Al-Marzooki, Zohair, Salah Ghareeb, Alasmari, Moudi M., Heba K. Alshaeri, Ghareeb, Salah   +15 more
core   +1 more source

Comparative assessment of kidney function biomarkers related to anti-diabetic medication consumption; a cross-sectional analysis [PDF]

Journal of Nephropathology
Introduction: Diabetic nephropathy is a main cause of chronic kidney disease (CKD) throughout the world, which requiring early detection and management.
Qutaiba A. Qasim, Hiba Dawood
doaj   +1 more source

Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones [PDF]

Diabetes & Metabolism Journal, 2011
BackgroundSulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ ...
Kyeong Won Lee, Yun Hyi Ku, Min Kim, Byung Yong Ahn, Sung Soo Chung, Kyong Soo Park   +5 more
doaj   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Standen, N.B., Yellon, D.M., Lawrence, C.L., Maddock, H.L., Mocanu, M.M.   +5 more
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