Results 21 to 30 of about 36,696 (303)

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]

, 1994
Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan, Aguilar-Bryan, Ashcroft, Bayley, De Weille, Ehle, Galizzi, Geisen, Geisen, Glossmann, Glossmann, Hogg, Hollemans, Kramer, Kramer, Kramer, Kramer, Martyr, Müller, Nelson, Nelson, Niki, Ozanne, Panten, Pomerantz, Repke, Schmid-Antomarchi, Schwanstecher, Skeer, Wessel   +29 more
core   +1 more source

Transcription factor 7-like 2 rs7903146 polymorphism and therapeutic response to sulfonylureas in patients with type 2 diabetes

Journal of Medicine in Scientific Research, 2018
Background Transcription factor 7-like 2 (TCF7L2) variations were related to a modified hypoglycemic reaction to sulfonylureas (SUs) in patients with type 2 diabetes mellitus (T2D).
Ghada A Omar, Ola Sayed M. Ali, Ashraf A Ismail, Ghada S Mohamed   +3 more
doaj   +1 more source

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group [PDF]

, 2018
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease.
Avery, C.L., Bis, J.C., Brody, J.A., Broer, L., Busch, E.L., Chen, Y.-DI., Cummings, S.R., Cupples, L.A., de Mutsert, R., Duan, Q., Eicher, J.D., Evans, D.S., Floyd, J.S., Gogarten, S.M., Gudnason, V., Harris, T.B., Heckbert, S.R., Johnson, A.D., Jukema, J.W., Kaplan, R.C., Kerr, K.F., Kors, J.A., Lange, L.A., Launer, L.J., Laurie, C.C., Li, J., Li, X., Li, Y., Li-Gao, R., Lin, H.J., Liu, Y., Mook-Kanamori, D.O., Méndez-Giráldez, R., Napier, M.D., Noordam, R., Psaty, B.M., Reiner, A.P., Rice, K.M., Roach, J., Rosendaal, F.R., Rotter, J.I., Sattar, N., Seyerle, A.A., Sitlani, C.M., Slagboom, P.E., Smith, A.V., Soliman, E.Z., Sotoodehnia, N., Stewart, J.D., Stott, D.J., Stricker, B.H., Stürmer, T., Taylor, K.D., Trompet, S., Uitterlinden, A.G., Whitsel, E.A., Wiggins, K.L., Wilhelmsen, K.C., Wilson, J.G.   +58 more
core   +4 more sources

Inpatient use of metformin and acarbose is associated with reduced mortality of COVID‐19 patients with type 2 diabetes mellitus

Endocrinology, Diabetes & Metabolism, 2022
Aims Type 2 diabetes mellitus (T2DM) is a strong risk factor for complications of coronavirus disease 2019 (COVID‐19). The effect of T2DM medications on COVID‐19 outcomes remains unclear.
Jinghong Li, Qi Wei, Karen C. McCowen, Wei Xiong, Jiao Liu, Wenlijun Jiang, Robert L. Thomas, Mark Hepokoski, Ming He, John Y. J. Shyy, Atul Malhotra, Nian Xiong, Willis X. Li   +12 more
doaj   +1 more source

Sulfonylureas Use Is Not Associated With Increased Infarct Size in Patients With Type 2 Diabetes and ST-Segment Elevation Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2021
Aims: This retrospective study assessed the association between sulfonylureas use and infarct size in patients with type 2 diabetes (T2DM) and ST-segment elevation myocardial infarction (STEMI) by myocardial enzymology indexes and cardiac magnetic ...
Fang-Hong Shi, Fang-Hong Shi, Hao Li, Ling-Cong Kong, Long Shen, Yi-Hong Jiang, Zhi-Chun Gu, Heng Ge   +7 more
doaj   +1 more source

SGLT-2 Inhibitors: A Novel Mechanism in Targeting Glycemic Control in Type 2 Diabetes Mellitus [PDF]

, 2016
OBJECTIVE: To review the chemistry, pharmacology, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, dosing, drug interactions, and administration of canagliflozin, dapagliflozin, and empagliflozin, and comparing the benefit and risk ...
Ahmed-Sarwar, Nabila, Nathan, Kobi T, Werner, Paul M   +2 more
core   +2 more sources

Injúria potencial de herbicidas de solo ao girassol: II - chlorimuron-ethyl Potential suflower injury by soil applied herbicides: II - chlorimuron-ethyl

Planta Daninha, 1993
Conduziu-se um ensaio de campo na Estação Experimental Agronômica da Universidade Federal do Rio Grande do Sul, em Eldorado do Sul, RS em 1989/90. O objetivo do trabalho foi determinar o efeito residual potencial do herbicida chlorimuron-ethyl aplicado ...
Nilson G. Fleck, Ribas A. Vidal
doaj   +1 more source

ABIOTIC DEGRADATION OF IODOSULFURON-METHYL-ESTER IN AQUEOUS SOLUTION [PDF]

, 2005
The abiotic degradation of iodosulfuron-methyl-ester was investigated under both alkaline and acidic pH conditions in the dark, and results showed it to be a rather stable molecule in neutral or slightly alkaline environments.
C. EMMELIN, J. M. CHOVELON, M. BRIGANTE, PREVITERA, LUCIO, R. BAUDOT   +4 more
core   +1 more source

Pharmacoeconomic aspects of the use of sulfonylurea drugs in type 2 diabetes mellitus

Сахарный диабет, 2011
In Russia, sulfonylurea drugs are extensively prescribed to patients with type 2 diabetes mellitus. This work was designed to study pharmacoeconomicaspects of application of 2nd generation sulfonylureas based on the results of the GUIDE study comparing ...
Alla Vsevolodovna Rudakova
doaj   +1 more source

Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006-2013. [PDF]

, 2016
ObjectiveTo examine temporal trends in utilization of glucose-lowering medications, glycemic control, and rate of severe hypoglycemia among patients with type 2 diabetes (T2DM).Research design and methodsUsing claims data from 1.66 million privately ...
Gill, Thomas M, Herrin, Jeph, Inzucchi, Silvio E, Krumholz, Harlan M, Lipska, Kasia J, McCoy, Rozalina G, Ross, Joseph S, Shah, Nilay D, Steinman, Michael A, Yao, Xiaoxi   +9 more
core   +1 more source