Results 41 to 50 of about 36,696 (303)

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]

, 2018
The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K., Hanson, Alex, Josifova, Dragana, McClenaghan, Conor, Nichols, Colin G., Roessler, Helen I., Sala-Rabanal, Monica, van Haaften, Gijs   +7 more
core   +2 more sources

Synthesis of Novel 1-(4-Substituted pyridine-3-sulfonyl)-3-phenylureas with Potential Anticancer Activity

Molecules, 2015
A series of novel 4-substituted-N-(phenylcarbamoyl)-3-pyridinesulfonamides 11–27 have been synthesized by the reaction of 4-substituted pyridine-3-sulfonamides 2–10 with the appropriate aryl isocyanates in presence of potassium carbonate.
Krzysztof Szafrański, Jarosław Sławiński   +1 more
doaj   +1 more source

Characterization of Ethoxysulfuron Herbicide Selectivity in Common Bean Cultivars [PDF]

Planta Daninha, 2018
: In literature, there are few studies evaluating the response of different bean cultivars to herbicides, particularly the ALS enzyme inhibitors. The objective of this study was to evaluate the selectivity of common bean cultivars to the herbicide ...
F.B. PAGNONCELLI JR, R.A. VIDAL, M.M. TREZZI, M. GALLON, A.P. BRUSAMARELLO   +4 more
doaj   +1 more source

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]

, 2010
ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E, Butler, Peter C, Costes, Safia, Daval, Marie, Gurlo, Tatyana, Huang, Chang-jiang, Matveyenko, Aleksey V, Rizza, Robert A   +7 more
core   +2 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Physiological Approach to the Use of the Natural Compound Quinate in the Control of Sensitive and Resistant Papaver rhoeas

Plants, 2020
Quinate (1,3,4,5-tetrahydroxycyclohexanecarboxylate) is a compound synthesized in plants through a side-branch of the shikimate biosynthesis pathway, which is accumulated after glyphosate and acetolactate synthase inhibiting herbicides (ALS-inhibitors ...
Ana Zabalza, Ainhoa Zulet-González, Maria Barco-Antoñanzas, Mikel V. Eceiza, Miriam Gil-Monreal, Mercedes Royuela   +5 more
doaj   +1 more source

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Altan, Aoki, Avruch, Bak, Begum, Brown, Caren, Clancy, Cooper, Cushman, Daniels, Davidson, Farese, Feldman, Feldman, Gavin, Geisen, Gould, Guinovart, Hirshman, Honnor, Jacobs, Jacobs, Jacobs, James, James, Karnieli, Kirsch, Klip, Kolterman, Kono, Lane, Larner, Lawrence, Lawson, Lebovitz, Leichter, Maloff, Mandarino, Misek, Moody, Müller, Müller, Müller, Müller, Müller, Okuno, Oron, Osegawa, Panten, Popov, Putnam, Reusch, Rogers, Roskoski, Saltiel, Saltiel, Saltiel, Simonson, Smith, Solomon, Standing, Suissa, Suzuki, Tordjman, Towbin, Van Putten, Vila, Villalba, Wang, Wang, Wieland, Wray, Yalow, Zinman, Zuber   +75 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Prevalence of Therapeutic Inertia in the Management of Overweight and Obesity in Patients With a Diagnosis of Type 2 Diabetes Who Are Followed up by Primary Care Physicians. [PDF]

Obes Sci Pract
ABSTRACT Introduction Information on therapeutic inertia (TI) in weight loss in people with type 2 diabetes (T2D) is limited. Objective To describe the prevalence of TI in the management of overweight/obesity in people with T2D undergoing primary care program (PCP) follow‐up and weight changes according to the prescribed treatment.
Aschner P, Henao-Carrillo D.
europepmc   +2 more sources

Impact of hypoglycemia on patients with type 2 diabetes mellitus and their quality of life, work productivity, and medication adherence. [PDF]

, 2014
BackgroundThe purpose of this study was to determine the characteristics of adults with type 2 diabetes mellitus (T2DM) that correlate with greater risk of hypoglycemia and determine the impact of hypoglycemia on health-related quality of life, work ...
Annunziata, Kathy, Bailey, Robert A, Lopez, Janice Ms, Morisky, Donald E, Rupnow, Marcia Ft   +4 more
core   +3 more sources